Role of soy lecithin combined with soy isoflavone on cerebral blood flow in rats of cognitive impairment and the primary screening of its optimum combination

Li, Hongrui; Wang, Xianyun; Li, Xiaoying; Zhou, Xueyang; Wang, Xuan; Li, Tiantian; Xiao, Rong; Xi, Yuandi

doi:10.4162/nrp.2023.17.2.371

Nutr Res Pract

2023

DOI: 10.4162/nrp.2023.17.2.371

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Role of soy lecithin combined with soy isoflavone on cerebral blood flow in rats of cognitive impairment and the primary screening of its optimum combination

Hongrui Li

Xianyun Wang

Xiaoying Li

et al.

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2024

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Lecithin’s antioxidant properties protect against cyclophosphamide-induced reproductive toxicity and infertility in male rats

Radhi,

Gatea

2024

Rev. Clin. Pharmacol. Pharmacokinet., Int. Ed.

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Background: Infertility is a prevalent problem that affects 15% of couples globally. Male infertility, which accounts for half of all cases, can be caused by several factors, including aging, drug use, genetic problems, and exposure to environmental toxins. Cyclophosphamide (CP) is a commonly utilized immunosuppressant and anticancer medication that can induce oxidative stress and harm the reproductive system of men. The beneficial effects of antioxidants in mitigating the CP-induced reproductive toxicities are well-documented. Aim: The aim of this study was to assess the effects of lecithin (as an antioxidant) against the CP-induced reproductive toxicity in male rats. Methodology: Thirty Sprague-Dawley male rats were divided into three groups: (i) the negative control group (that received sterile water via the intragastric route for 13 consecutive days), (ii) the positive control group (that received sterile water via the intragastric route for 5 days and, subsequently, a single, intraperitoneal dose of CP on day 6, followed by sterile water via the intragastric route for the next 7 consecutive days), and (iii) the lecithin-treated group (that received lecithin via the intragastric route for 5 days and, subsequently, a single, intraperitoneal dose of CP on day 6, followed by lecithin via the intragastric route for the next 7 consecutive days). Results: Lecithin treatment improved sperm parameters, plasmatic testosterone levels, and glutathione peroxidase, thereby preventing histopathological alterations in the rat testes. Conclusion: Lecithin demonstrated its potential protective effects against reproductive impairments and oxidative stress in the CP-treated rat group, and might prove promising for use in clinical practice as a protective agent against chemotherapy-induced male reproductive toxicity and infertility.

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Lecithin’s antioxidant properties protect against cyclophosphamide-induced reproductive toxicity and infertility in male rats

Radhi,

Gatea

2024

Rev. Clin. Pharmacol. Pharmacokinet., Int. Ed.

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show abstract

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Role of soy lecithin combined with soy isoflavone on cerebral blood flow in rats of cognitive impairment and the primary screening of its optimum combination

Cited by 1 publication

References 32 publications

Lecithin’s antioxidant properties protect against cyclophosphamide-induced reproductive toxicity and infertility in male rats

Lecithin’s antioxidant properties protect against cyclophosphamide-induced reproductive toxicity and infertility in male rats

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