“…Various genetic and transcriptional aberrations have been connected to the acquisition of lineage plasticity in PCa, including, but not limited to, the aberrations of PTEN, BRN2, FOXA1, N-Myc, PEG10, CHD1, REST, and BRG1 (7,(11)(12)(13)(14)(15)(16). Interestingly, many of those cases involve the "hijacking" of stem-like, pluripotency, or epigenetic regulation programs, such as SOX2, SOX11, EZH2, and the SWI/SNF complex (9,10,(13)(14)(15)18). Although the role of JAK-STAT signaling pathway in regulating cell fate decision, stem cell self-renewal, and multilineage differentiation has been well documented (23)(24)(25), its potential function in mediating lineage plasticity-driven AR therapy resistance remained largely unclear.…”