Role of Spirulina in mitigating hemato-toxicity in Swiss albino mice exposed to aluminum and aluminum fluoride

Sharma, Shweta; Sharma, Kanta Prasad; Sharma, Shagun

doi:10.1007/s11356-016-7718-6

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Regarding the leukocyte count, we did not find significant differences and this result contrasts with that previously reported by Sharma et al [59], who reported an increase in these blood cells, especially, in neutrophils and monocytes due to activation of the immune system in response to a foreign agent [59].…”

Section: Blood Cytometrycontrasting

confidence: 99%

“…In these images, no morphological changes were observed in any of the study groups or cell types present in the smears. These results differ from those reported previously, where a high incidence of poikilocytosis was observed in the erythrocytes of the groups treated with aluminum [59,62]. Likewise, Bazzoni et al [42] observed a predominance of stomatocytes and the study published by Cheng et al [43] reported the presence of Heinz bodies in erythrocytes.…”

Section: Differential Blood Smear Analysiscontrasting

confidence: 59%

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Hematologic evaluation of peripheral blood in Sprague Dawley rats by chronic exposure to aluminum chloride (AlCl3)

Valenzuela-Briseño

Arredondo-Damian

Rascón-Careaga

et al. 2022

Environ Anal Health Toxicol

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This study aimed to evaluate whether aluminum chloride (AlCl3) causes hematological changes in the peripheral blood of Sprague–Dawley (SD) rats. Five groups of female SD rats were intragastrically administered with 4 different concentrations of AlCl3 for 5 days a week for a total of 90 days. The aluminum concentration was determined via graphite furnace atomic absorption spectroscopy. Analysis of serum iron-kinetic profiles, blood cytometry outcomes, and blood smears of the blood samples. Scanning electron microscopy (SEM) and Raman spectroscopy were used to search for structural and ultrastructural changes, respectively. Blood aluminum concentration ranged 12.38-16.24 μg/L with no significant difference between experimental treatments. At the AlCl3 concentration of 40 mg Al/kg bw of rats/day, the mean ferritin value in the serum iron kinetic profile was 29.81±6.1 ng/mL, and this value showed a significant difference between experimental treatments. Blood cytometry revealed that there were 6.45-7.11×106 cells/μL erythrocytes, 8.91-9.32×103 cells/μL leukocytes, and 477.2-736.3×103 cells/μL platelets along with a hemoglobin of 37.38-41.93 g/dL and hematocrit level of 37.38-41.93%; the experimental treatments showed no significant differences. Erythrocyte structural analysis using SEM showed no differences between experimental treatments, whereas ultrastructural evaluation using Raman spectroscopy made it possible to identify the following bands: 741, 1123, 1350, 1578, and 1618 cm−1, which were respectively associated with the following vibrational modes and compounds: vibration of the tryptophan ring, asymmetric C-O-C stretching of glucose, C-H curve of tryptophan, C=C stretching of the heme group, and C-N stretching of the heme group, with no significant differences between experimental treatments. Therefore, AlCl3 administration does not induce ultrastructural changes in the erythrocyte membrane. This study revealed that serum ferritin concentration was the only parameter affected by AlCl3 exposure at 40 mg of Al/kg bw of rats/day.

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Section: Blood Cytometrycontrasting

confidence: 99%

Section: Differential Blood Smear Analysiscontrasting

confidence: 59%

Hematologic evaluation of peripheral blood in Sprague Dawley rats by chronic exposure to aluminum chloride (AlCl3)

Valenzuela-Briseño

Arredondo-Damian

Rascón-Careaga

et al. 2022

Environ Anal Health Toxicol

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“…Aluminum is an active metal. When aluminum is exposed to air, an oxide film with a thickness of about 0.5 nm is formed on the surface, protecting the metal aluminum from further corrosion [16][17][18]. Aluminum is very soluble in strong alkali, and also soluble in dilute acid.…”

Section: Introductionmentioning

confidence: 99%

CuO/Al2O3 Catalyst Preparation Conditions for Removal of Nitrobenzene by Heterogeneous Fenton-Like System

Wu¹,

Liu²,

Ding³

et al. 2020

Pol. J. Environ. Stud.

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In order to effectively remove nitrobenzene-containing wastewater, nitrobenzene was degraded by heterogeneous Fenton system in this study. CuO/Al 2 O 3 catalysts were prepared by different methods and conditions. The characteristics of CuO/Al 2 O 3 were analyzed by BET, X-ray diffraction (XRD) and scanning electron microscope (SEM). Among them, the specific surface area, pore volume and pore size of CuO/Al 2 O 3 were characterized by BET; the phase and crystallinity of the CuO/Al 2 O 3 were determined by XRD; the surface morphology of the CuO/Al 2 O 3 was observed by SEM. Nitrobenzene concentration was determined by HPLC. The nitrobenzene-containing wastewater was degraded by a heterogeneous Fenton-Like system catalyzed with prepared CuO/Al 2 O 3. The results showed that the optimal preparation method of the catalyst was the deposition precipitation method. The optimal conditions of the catalyst were as follows: the loading content of CuO was 5%, the calcination temperature of CuO was 400ºC, the calcination time of CuO was 3 h, and the calcination temperature of Al 2 O 3 carrier was 400ºC. The removal rate of nitrobenzene reached 84.37% under this condition. This study shows that the nitrobenzene could be effectively degraded in a heterogeneous Fenton-like system catalyzed by CuO/Al 2 O 3 .

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Ameliorating effects of Rhamnus alaternus L. aqueous extract on aluminum chloride-induced nephrotoxicity via attenuation of oxidative stress in male Wistar rats

Tichati

Benzaid²,

Trea³

et al. 2022

Comp Clin Pathol

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Role of Spirulina in mitigating hemato-toxicity in Swiss albino mice exposed to aluminum and aluminum fluoride

Cited by 4 publications

References 32 publications

Hematologic evaluation of peripheral blood in Sprague Dawley rats by chronic exposure to aluminum chloride (AlCl3)

Hematologic evaluation of peripheral blood in Sprague Dawley rats by chronic exposure to aluminum chloride (AlCl3)

CuO/Al<sub>2</sub>O<sub>3</sub> Catalyst Preparation Conditions for Removal of Nitrobenzene by Heterogeneous Fenton-Like System

Ameliorating effects of Rhamnus alaternus L. aqueous extract on aluminum chloride-induced nephrotoxicity via attenuation of oxidative stress in male Wistar rats

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