Role of stem cell derivatives in inflammatory diseases

Yang, Yuxi; Peng, Yiqiu; Li, Yingying; Shi, Tingjuan; Luan, Yingyi; Yin, Chenghong

doi:10.3389/fimmu.2023.1153901

Cited by 11 publications

(10 citation statements)

References 107 publications

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“…Exosomes are heterogeneous nanosomes that mediate intercellular communication. [ 36 ] As an important biological carrier, exosomes have been proved to contain a variety of substances including circRNA. [ 37,38 ] Given the importance of circRNA in the progression of cancer, the detection of exosomal RNA in patient body fluids is of great value for the diagnosis and prognosis of cancer.…”

Section: Discussionmentioning

confidence: 99%

Exosomal circ_0000735 contributes to non‐small lung cancer malignant progression

Liu,

Wu,

Wang

et al. 2024

J Biochem & Molecular Tox

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Circular RNA is an important regulator for non‐small cell lung cancer (NSCLC). Circ_0000735 has been found to be significantly overexpressed in NSCLC tissues. Therefore, its role and mechanism in NSCLC progression need to be further explored. The expression levels of circ_0000735, miR‐345‐5p and A disintegrin and metalloprotease 19 (ADAM19) were determined using quantitative real‐time PCR. EdU staining, wound healing and transwell assays were utilized to detect cell proliferation and metastasis. The protein levels of metastasis markers, exosome markers and ADAM19 were determined using western blot. Animal experiments were performed to confirm the role of circ_0000735 in NSCLC tumorigenesis. The exosomes from cells and serum were identified using transmission electron microscopy and nanoparticle tracking analysis. We found that circ_0000735 was upregulated in NSCLC, and its knockdown repressed NSCLC cell proliferation and metastasis. In terms of mechanism, circ_0000735 targeted miR‐345‐5p to regulate ADAM19. MiR‐345‐5p inhibitor reversed the suppressive effect of circ_0000735 knockdown on NSCLC progression, and ADAM19 overexpression abolished the inhibition effect of miR‐345‐5p on NSCLC progression. Also, animal experiments showed that silencing of circ_0000735 reduced NSCLC tumorigenesis. In addition, exosomes mediated the intercellular transmission of circ_0000735, and serum exosomal circ_0000735 might be an important indicator for the diagnosis of NSCLC. In conclusion, circ_0000735 facilitated NSCLC progression via miR‐345‐5p/ADAM19 pathway, and serum exosomal circ_0000735 might be a potential biomarker for NSCLC diagnosis.

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Section: Discussionmentioning

confidence: 99%

Exosomal circ_0000735 contributes to non‐small lung cancer malignant progression

Liu,

Wu,

Wang

et al. 2024

J Biochem & Molecular Tox

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“…The cargo of these exosomes contain proteins with various anti-colitis properties, especially metallothionein-2 [ 133 , 134 ]. Further relevant cargo include various miRNAs, which play a crucial role in immune system coordination through regulating T cells and NF-κB pathways; these miRNAs include miR-146a and miR-155 [ 135 ]. Furthermore, it has also been demonstrated that exosome treatment in IBD can normalize the intestinal microbiome, especially via IPSC-derived exosomes [ 136 ].…”

Section: Potential Therapeutic Applications In Disease and Regenerati...mentioning

confidence: 99%

Therapeutic Applications of Stem Cell-Derived Exosomes

Abdulmalek,

Husain,

AlKhalifa

et al. 2024

IJMS

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Exosomes are extracellular vesicles of endosomal origin, ranging from 30 to 150 nm in diameter, that mediate intercellular transfer of various biomolecules, such as proteins, lipids, nucleic acids, and metabolites. They modulate the functions of recipient cells and participate in diverse physiological and pathological processes, such as immune responses, cell–cell communication, carcinogenesis, and viral infection. Stem cells (SCs) are pluripotent or multipotent cells that can differentiate into various cell types. SCs can also secrete exosomes, which exhibit remarkable therapeutic potential for various diseases, especially in the field of regenerative medicine. For example, exosomes derived from mesenchymal stem cells (MSCs) contain proteins, lipids, and miRNAs that can ameliorate endocrine disorders, such as diabetes and cancer. Exosomes from SCs (sc-exos) may offer similar advantages as SCs, but with reduced risks and challenges. Sc-exos have lower tumorigenicity, immunogenicity, and infectivity. They can also deliver drugs more efficiently and penetrate deeper into tissues. In this review, we provide an overview of the recent advances in sc-exos and their therapeutic applications in various diseases, such as diabetes and cancer. We also elucidate how the biological effects of sc-exos depend on their molecular composition. We also address the current challenges and future directions of using sc-exos.

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“…This approach is gaining increasing attention due to its benefits, notably excellent safety, ease of administration, and scalability. In contrast to traditional cell‐based therapies that require the transplantation of live cells, which can be challenging to obtain and preserve, cell‐free therapeutics can be produced in large quantities and stored for extended periods, making them more accessible for clinical use 2 . Furthermore, cell‐free therapies may pose a low risk of immune rejection provided that they do not contain live cells that could trigger an immune response.…”

Section: Main Issuementioning

confidence: 99%

Mesenchymal stem/stromal cell‐based cell‐free therapy for the treatment of acute lung injury

Cui,

Lv,

Chen

et al. 2023

J of Cellular Biochemistry

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Acute lung injury (ALI) is a severe medical condition that causes inflammation and fluid buildup in the lung, resulting in respiratory distress. Moreover, ALI often occurs as a complication of other medical conditions or injuries, including the coronavirus disease of 2019. Mesenchymal stem/stromal cells (MSCs) are being studied extensively for their therapeutic potential in various diseases, including ALI. The results of recent studies suggest that the beneficial effects of MSCs may not be primarily due to the replacement of damaged cells but rather the release of extracellular vesicles (EVs) and other soluble factors through a paracrine mechanism. Furthermore, EVs derived from MSCs preserve the therapeutic action of the parent MSCs and this approach avoids the safety issues associated with live cell therapy. Thus, MSC‐based cell‐free therapy may be the focus of future clinical treatments.

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Role of stem cell derivatives in inflammatory diseases

Cited by 11 publications

References 107 publications

Exosomal circ_0000735 contributes to non‐small lung cancer malignant progression

Exosomal circ_0000735 contributes to non‐small lung cancer malignant progression

Therapeutic Applications of Stem Cell-Derived Exosomes

Mesenchymal stem/stromal cell‐based cell‐free therapy for the treatment of acute lung injury

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