Role of stem cells in cancer therapy and cancer stem cells: a review

Sagar, Jayesh; Chaib, Boussad; Sales, Kevin M.; Winslet, Marc C.; Seifalian, Alexander M.

doi:10.1186/1475-2867-7-9

Cited by 120 publications

(88 citation statements)

References 113 publications

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“…It has been shown that chemotherapy can induce inhibitory factors such as Tumor Growth Factor(TNF)-α and Interleukin(IL)-4 with cytokines that causes myelosupression. The adequate number of the stem cells therapy is also reported crucial factors for speedy recovery [49]. Therefore, based on above conclusion the following recommendations are forwarded:…”

Section: Stem Cells In Immuno-reconstitutionmentioning

confidence: 99%

“…The potential of stem cell therapies has long been recognized and the creation of iPSC has boosted the stem cell field leading to increasing development and scientific knowledge [39]. For over 30 years, stem cells have been used in the replenishment of blood and immune systems damaged by the cancer cells [49].…”

Section: Role Of Stem Cell Therapy In Cancermentioning

confidence: 99%

“…MSC transduced with an adenoviral expression vector carrying interferon-β gene has been demonstrated to increase the production of interferon-β at the local site [49]. Anticancer mechanisms of interferon are immunostimulatory and by inducing programmed cell death (apoptosis) [1].…”

Section: Stem Cells As Delivery Vehicles In Gene Therapymentioning

confidence: 99%

See 2 more Smart Citations

Review on Stem Cell Therapy and their Role in Cancer Treatment

Mitku¹,

Tesfaye²,

Wubshet³

2017

IJBB

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Section: Stem Cells In Immuno-reconstitutionmentioning

confidence: 99%

Section: Role Of Stem Cell Therapy In Cancermentioning

confidence: 99%

See 1 more Smart Citation

Review on Stem Cell Therapy and their Role in Cancer Treatment

Mitku¹,

Tesfaye²,

Wubshet³

2017

IJBB

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“…CSCs are a small population present in cancer cells with unique properties: i) self-renewal capability, ii) cell differentiation ability and iii) cancer initiation potential (33,34). These properties of CSCs contribute to chemoradiotherapy resistance and cause tumor recurrence.…”

Section: The Resistance Mechanisms Of Cscsmentioning

confidence: 99%

Cancer stem cells: The potential of carbon ion beam radiation and new radiosensitizers (Review)

et al. 2015

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Abstract. Cancer stem cells (CSCs) are a small population of cells in cancer with stem-like properties such as cell proliferation, multiple differentiation and tumor initiation capacities. CSCs are therapy-resistant and cause cancer metastasis and recurrence. One key issue in cancer therapy is how to target and eliminate CSCs, in order to cure cancer completely without relapse and metastasis. To target CSCs, many cell surface markers, DNAs and microRNAs are considered as CSC markers. To date, the majority of the reported markers are not very specific to CSCs and are also present in nonCSCs. However, the combination of several markers is quite valuable for identifying and targeting CSCs, although more specific identification methods are needed. While CSCs are considered as critical therapeutic targets, useful treatment methods remain to be established. Epigenetic gene regulators, microRNAs, are associated with tumor initiation and progression. MicroRNAs have been recently considered as promising therapeutic targets, which can alter the therapeutic resistance of CSCs through epigenetic modification. Moreover, carbon ion beam radiotherapy is a promising treatment for CSCs. Evidence indicates that the carbon ion beam is more effective against CSCs than the conventional X-ray beam. Combination therapies of radiosensitizing microRNAs and carbon ion beam radiotherapy may be a promising cancer strategy. This review focuses on the identification and treatment resistance of CSCs and the potential of microRNAs as new radiosensitizers and carbon ion beam radiotherapy as a promising therapeutic strategy against CSCs.

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“…Trials are on the way to treat various diseases. Stem cell transplant is considered as an option for the treatment of certain type of cancers [19]. This medical procedure can also be used to treat neurological diseases [20], autoimmune diseases [21], restoration of sight [22], wound healing [23], heart diseases [24], liver diseases [25], metabolic disorders [26], spinal cord injury [27] etc.…”

Section: Stem Cell Transplantmentioning

confidence: 99%

Bone Marrow Transplantation

Krishna¹,

Rao²

2009

TOBIOTJ

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Stem cells are the centre for regenerative medicine. Given a right signal these undifferentiated cells have a remarkable potential to develop into specialized cell types (blood cells, heart cells etc.) in the human body. Stem cells, therefore, can be used in cell-based therapies to replace/repair damaged tissues and/or organs. Ongoing research in the area of stem cells focuses on their potential application (both embryonic stem cells and adult stem cells) to create specialized cells and replace the damaged ones. Hence, this cutting-edge technology might lead to new ways of detecting and treating diseases. Stem cell transplantation can be considered as an option for the treatment of certain type of cancers. This medical procedure can also be used to treat neurological diseases, autoimmune diseases, heart diseases, liver diseases, metabolic disorders, spinal cord injury etc. The present review, therefore, focuses on the growing use of stem cell transplantation in regenerative medicine to treat a variety of diseases. This review also provides the current status of the field with a particular emphasis on bone marrow transplantation.

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Role of stem cells in cancer therapy and cancer stem cells: a review

Cited by 120 publications

References 113 publications

Review on Stem Cell Therapy and their Role in Cancer Treatment

Review on Stem Cell Therapy and their Role in Cancer Treatment

Cancer stem cells: The potential of carbon ion beam radiation and new radiosensitizers (Review)

Bone Marrow Transplantation

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