Base of penile abscesses are uncommon genitourinary tract infection. We present a case of a 31 years old man with poorly controlled diabetes mellitus, whom presented with scrotal pain and scrotal swelling for 1 week duration. Physical examination revealed a bulging mass at the base of penis. A high index of suspicion is needed to look for possible causes such as extension of abscess from perineum or anorectal, sexually transmitted disease, tuberculosis, history of penile instrumentation or injection and trauma. A large abscess at the base of penis was diagnosed by magnetic resonance imaging. He was successfully treated with transperineal incision and drainage, systemic antibiotic therapy, wound care and strict diabetic control. To the best of our knowledge, this is the first report of isolated base of penile abscess. The description of case, comprising the clinical presentation and management, is discussed in detailed with emphasis on the treatment approach.