Role of substrate competition in the pathogenesis of insulin resistance in man

Tappy, Luc; Acheson, K. J.

doi:10.1530/eje.0.1380010

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Obesity and Regulators Of Gh Secretion1

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2002

2010

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Cited by 2 publications

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“…Insulin inhibits hepatic production of IGFBP-1 [37] increasing free IGF-I levels, which may enhance insulin action but may also exert a negative feedback on GH release. Moreover, insulin resistance and subsequently hyperinsulinism involve high glucose, free fatty acids (FFA) and amino acid plasmatic levels [51], all of which can exert a negative effect on GH release. Furthermore, high insulin levels suppress ghrelin release in obesity.…”

Section: Obesity and Regulators Of Gh Secretionmentioning

confidence: 99%

GH/IGF-I Regulation in Obesity – Mechanisms and Practical Consequences in Children and Adults

Kreitschmann-Andermahr

Suarez²,

Jennings³

et al. 2010

Horm Res Paediatr

104

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Growth hormone (GH) secretion in children and adults is profoundly, but reversibly, suppressed in obesity. Since GH deficiency leads to increased fat mass, differentiation of both conditions remains challenging. Here we review the known and still speculative mechanisms underlying the inhibitory effects of obesity on GH secretion including peripheral factors like IGF-I and insulin, as well as central hypothalamic/pituitary modulators. We further discuss the basis of current testing for GH deficiency in obesity and the validity of the various provocative tests in overweight subjects.

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Section: Obesity and Regulators Of Gh Secretionmentioning

confidence: 99%