Role of surface charge and wettability on early stage mineralization and bone cell–materials interactions of polarized hydroxyapatite

Bodhak, Subhadip; Bose, Susmita; Bandyopadhyay, Amit

doi:10.1016/j.actbio.2009.02.023

Cited by 254 publications

(190 citation statements)

References 30 publications

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“…Huge research efforts are dedicated to understanding these effects, and experimental results have shown that each situation (e.g. stiff vs. soft substrate, 10 flat vs. roughened topology, 11 positive vs. negatively charged surface, 12 static vs. stretched surface 13 etc.) plays a role in governing cellular dynamics and function.…”

Section: Interaction Of Cells With Their Microenvironmentmentioning

confidence: 99%

Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches

Denning

Roos

2016

Cell Adhesion & Migration

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The use of synthetic surfaces and materials to influence and study cell behavior has vastly progressed our understanding of the underlying molecular mechanisms involved in cellular response to physicochemical and biophysical cues. Reconstituting cytoskeletal proteins and interfacing them with a defined microenvironment has also garnered deep insight into the engineering mechanisms existing within the cell. This review presents recent experimental findings on the influence of several parameters of the extracellular environment on cell behavior and fate, such as substrate topography, stiffness, chemistry and charge. In addition, the use of synthetic environments to measure physical properties of the reconstituted cytoskeleton and their interaction with intracellular proteins such as molecular motors is discussed, which is relevant for understanding cell migration, division and structural integrity, as well as intracellular transport. Insight is provided regarding the next steps to be taken in this interdisciplinary field, in order to achieve the global aim of artificially directing cellular response.

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Section: Interaction Of Cells With Their Microenvironmentmentioning

confidence: 99%

Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches

Denning

Roos

2016

Cell Adhesion & Migration

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“…This proteinaceous matrix promotes the ingrowth of connective tissue, cells or vessels as it is described for osteoconduction, but also enhances chemotaxis and differentiation of osteoprogenitor cells as it occurs in osteoinduction. Fibronectin and vitronectin are typical extracellular matrix proteins adsorbed, which favor spreading and proliferation of cells, as tests with human fetal osteoblasts have revealed [63].…”

Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 99%

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

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Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

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“…The presence of surface charges on HA bioceramics was shown to have a significant effect on both in vitro and in vivo crystallization of biological apatite [336][337][338][339][340]. Furthermore, a growth of both biomimetic calcium orthophosphates and bones was found to be accelerated on negatively charged surfaces and decelerated at positively charged surfaces [340][341][342][343][344][345][346][347][348][349]. In addition, the electrical polarization of HA bioceramics was found to accelerate a cytoskeleton reorganization of osteoblastlike cells [350][351][352], extend bioactivity [353] and enhance bone ingrowth through the pores of porous HA implants [354].…”

Section: Electrical Propertiesmentioning

confidence: 99%

“…For example, there is an interest in polarization of HA bioceramics to generate a surface charge by the application of electric fields at elevated temperatures [334,335]. The presence of surface charges on HA bioceramics was shown to have a significant effect on both in vitro and in vivo crystallization of biological apatite [336][337][338][339][340]. Furthermore, a growth of both biomimetic calcium orthophosphates and bones was found to be accelerated on negatively charged surfaces and decelerated at positively charged surfaces [340][341][342][343][344][345][346][347][348][349].…”

Section: Electrical Propertiesmentioning

confidence: 99%

Untitled

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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Role of surface charge and wettability on early stage mineralization and bone cell–materials interactions of polarized hydroxyapatite

Cited by 254 publications

References 30 publications

Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches

Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

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