Role of sympathoadrenomedullary system in cardiovascular response to stress in rats

Barron, Barbara A.; Loon, Glen R. Van

doi:10.1016/0165-1838(89)90090-8

Cited by 58 publications

(33 citation statements)

References 13 publications

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“…Restraint-induced tachycardia is well documented (1,5,12), but effects of autonomic blockade on cardiac changes during restraint have not been assessed. We found that ␤-adrenergic blockade completely abolished the steady-state tachycardia and substantially reduced the initial transient tachycardic component.…”

Section: Autonomic Mechanisms Involved In Cardiac Control During Strementioning

confidence: 99%

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Activation of 5-HT_1A receptors attenuates tachycardia induced by restraint stress in rats

Ngampramuan¹,

Baumert²,

Beig³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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To better understand the central mechanisms that mediate increases in heart rate (HR) during psychological stress, we examined the effects of systemic and intramedullary (raphe region) administration of the serotonin-1A (5-HT1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT) on cardiac changes elicited by restraint in hooded Wistar rats with preimplanted ECG telemetric transmitters. 8-OH-DPAT reduced basal HR from 356 Ϯ 12 to 284 Ϯ 12 beats/min, predominantly via a nonadrenergic, noncholinergic mechanism. Restraint stress caused tachycardia (an initial transient increase from 318 Ϯ 3 to 492 Ϯ 21 beats/min with a sustained component of 379 Ϯ 12 beats/min). ␤-Adrenoreceptor blockade with atenolol suppressed the sustained component, whereas muscarinic blockade with methylscopolamine (50 g/kg) abolished the initial transient increase, indicating that sympathetic activation and vagal withdrawal were responsible for the tachycardia. Systemic administration of 8-OH-DPAT (10, 30, and 100 g/kg) attenuated stress-induced tachycardia in a dose-dependent manner, and this effect was suppressed by the 5-HT1A antagonist WAY-100635 (100 g/kg). Given alone, the antagonist had no effect. Systemically injected 8-OH-DPAT (100 g/kg) attenuated the sympathetically mediated sustained component (from ϩ85 Ϯ 19 to ϩ32 Ϯ 9 beats/min) and the vagally mediated transient (from ϩ62 Ϯ 5 to ϩ25 Ϯ 3 beats/min). Activation of 5-HT1A receptors in the medullary raphe by microinjection of 8-OH-DPAT mimicked the antitachycardic effect of the systemically administered drug but did not affect basal HR. We conclude that tachycardia induced by restraint stress is due to a sustained increase in cardiac sympathetic activity associated with a transient vagal withdrawal. Activation of central 5-HT1A receptors attenuates this tachycardia by suppressing autonomic effects. At least some of the relevant receptors are located in the medullary rapheparapyramidal area.serotonin; psychological stress; heart rate; sympathetic; medullary raphe THAT PSYCHOLOGICAL STRESS consistently elicits sympathetically mediated tachycardic responses is firmly established, but the central mechanisms generating increases in cardiac sympathetic activity remain poorly understood (6). In addition to a theoretical interest, this issue is of major clinical importance, inasmuch as the ability to suppress potentially deleterious increases in cardiac sympathetic activity at its origin, in the brain, would be a valuable alternative to widely used ␤-blockers. Few attempts have been made to reach this goal, mainly because of a lack of knowledge of the localization and pharmacological sensitivity of presympathetic cardiomotor neurons. Recent evidence indicates that the final medullary relay for the descending pathways that activate the heart during stress is located in the raphe-parapyramidal area and that relevant cardiomotor neurons are sensitive to, and could be inhibited by, serotonin-1A (5-HT 1A ) receptor agonists (13,23).Involvement of 5-HT 1A receptors in cardiovasc...

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Section: Autonomic Mechanisms Involved In Cardiac Control During Strementioning

confidence: 99%

“…Restraint consistently elicits a robust rise in arterial pressure and heart rate (HR) (1,5,12). However, the autonomic mechanisms mediating restraint-induced tachycardia have not been characterized, and the effects of 5-HT agonists on restraint-induced cardiac effects have not been tested.…”

mentioning

confidence: 99%

Activation of 5-HT_1A receptors attenuates tachycardia induced by restraint stress in rats

Ngampramuan¹,

Baumert²,

Beig³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Because this system modulates cardiovascular and immune functions (65,66), excess activation of the sympatho-adrenomedullary system induced by high levels of stress may thus contribute to the development of cardiovascular diseases such as hypertension and certain diseases of the immune system (67,68). Therefore, in order to clarify the mechanisms of the stress-related diseases, we have been examining the central regulatory mechanisms of sympatho-adrenomedullary outflow using several stress-related neuropeptides including bombesin.…”

Section: V) A)mentioning

confidence: 99%

Stimulatory and Inhibitory Roles of Brain 2-Arachidonoylglycerol in Bombesin-Induced Central Activation of Adrenomedullary Outflow in Rats

2013

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Abstract. 2-Arachidonoylglycerol (2-AG) is recognized as a potent endocannabinoid, which reduces synaptic transmission through cannabinoid CB 1 receptors, and is hydrolyzed by monoacylglycerol lipase (MGL) to arachidonic acid (AA), a cyclooxygenase substrate. We already reported that centrally administered MGL and cyclooxygenase inhibitors each reduced the intracerebroventricularly (i.c.v.) administered bombesin-induced secretion of adrenal catecholamines, while a centrally administered CB 1 -antagonist potentiated the response, indirectly suggesting bidirectional roles of brain 2-AG (stimulatory and inhibitory roles) in the bombesin-induced response. In the present study, we separately examined these bidirectional roles using 2-AG and 2-AG ether (2-AG-E) (stable 2-AG analog for MGL) in rats.

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“…Nicotine administered into the rostral ventrolateral medulla increases blood pressure and renal sympathetic nerve activity (Tseng et al, 1993(Tseng et al, , 1994, whereas nicotine administration into the nucleus tractus solitarius induces hypotension, probably by an enhancement of inhibitory baroreflex (Tseng et al, 1993(Tseng et al, , 1994Ashworth-Preece et al, 1998). Chronic treatment of nicotine is able to intensify and accelerate the development of hypertension in spontaneously hypertensive rats (Bui et al, 1994;Ferrari and Fior-Chadi, 2007), in which the central dysregulation of sympatho-adrenomedullary outflow has been suggested to be involved (Barron and Van Loon, 1989;Wyss and Carlson, 2001;Guyenet, 2006). However, the precise mechanisms of this alkaloid-induced central modulation of the sympathoadrenomedullary outflow are largely undefined.…”

Section: Introductionmentioning

confidence: 99%

Brain cyclooxygenase and prostanoid TP receptors are involved in centrally administered epibatidine-induced secretion of noradrenaline and adrenaline from the adrenal medulla in rats

Shimizu

Yokotani

2009

European Journal of Pharmacology

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Role of sympathoadrenomedullary system in cardiovascular response to stress in rats

Cited by 58 publications

References 13 publications

Activation of 5-HT_1A receptors attenuates tachycardia induced by restraint stress in rats

Activation of 5-HT_1A receptors attenuates tachycardia induced by restraint stress in rats

Stimulatory and Inhibitory Roles of Brain 2-Arachidonoylglycerol in Bombesin-Induced Central Activation of Adrenomedullary Outflow in Rats

Brain cyclooxygenase and prostanoid TP receptors are involved in centrally administered epibatidine-induced secretion of noradrenaline and adrenaline from the adrenal medulla in rats

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Role of sympathoadrenomedullary system in cardiovascular response to stress in rats

Cited by 58 publications

References 13 publications

Activation of 5-HT1A receptors attenuates tachycardia induced by restraint stress in rats

Activation of 5-HT1A receptors attenuates tachycardia induced by restraint stress in rats

Stimulatory and Inhibitory Roles of Brain 2-Arachidonoylglycerol in Bombesin-Induced Central Activation of Adrenomedullary Outflow in Rats

Brain cyclooxygenase and prostanoid TP receptors are involved in centrally administered epibatidine-induced secretion of noradrenaline and adrenaline from the adrenal medulla in rats

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Activation of 5-HT_1A receptors attenuates tachycardia induced by restraint stress in rats

Activation of 5-HT_1A receptors attenuates tachycardia induced by restraint stress in rats