2002
DOI: 10.1590/s0100-879x2002001000009
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Role of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization

Abstract: One of the defenses against nephrolithiasis is provided by macromolecules that modulate the nucleation, growth, aggregation and retention of crystals in the kidneys. The aim of the present study was to determine the behavior of two of these proteins, Tamm-Horsfall and uromodulin, in calcium oxalate crystallization in vitro. We studied a group of 10 male stone formers who had formed at least one kidney stone composed of calcium oxalate. They were classified as having idiopathic nephrolithiasis and had no well-k… Show more

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Cited by 33 publications
(17 citation statements)
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“…THGP-deficient mice were shown to be severely hampered in combating colonization of bladder tissue when infected with type 1 fimbriated E. coli (8,9). Moreover, THGP by reducing calcium oxalate precipitation plays a protective role with respect to renal stone formation as demonstrated by recent studies on THGP-deficient mice prone to nephrolithiasis (10,11).…”
Section: Tamm-horsfall Glycoprotein (Thgp)mentioning
confidence: 99%
“…THGP-deficient mice were shown to be severely hampered in combating colonization of bladder tissue when infected with type 1 fimbriated E. coli (8,9). Moreover, THGP by reducing calcium oxalate precipitation plays a protective role with respect to renal stone formation as demonstrated by recent studies on THGP-deficient mice prone to nephrolithiasis (10,11).…”
Section: Tamm-horsfall Glycoprotein (Thgp)mentioning
confidence: 99%
“…Under normal conditions, the crystals of calcium oxalate that form are small and well protected from crystal growth and crystal aggregation by a cover of inhibitory macromolecules. If inhibitors of crystal formation were not able to act and control their size, the final result will be nephrolithiasis (24,25). Proteins which cover crystal surface and may lead to inhibition of its growth or ability to aggregate while the same proteins bound to a surface may act to accumulate salt ions and forms a template for the first nucleus.…”
Section: Discussionmentioning
confidence: 99%
“…The urine blocked formation of crystals until CaOx SS reached 10. This effect is probably due to several non-dialyzable macromolecular inhibitors present in it, like nephrocalcin, glycosaminoglycans, Tamm-Horsfall/uromodulin, and osteopontin for example (2)(3)(11)(12). When the relative SS varied between 10 and 30, there was an interesting relationship among these inhibitors of crystallization and the physicochemical burden imposed by high concentration of calcium and oxalate.…”
Section: Discussionmentioning
confidence: 99%
“…Supersaturation (SS) in relation calcium oxalate and phosphate salts is the driving force for crystallization in solutions like urine, which means that it will contain crystals that are formed spontaneously. If inhibitors of crystal formation were not able to act and control their size, the final result will be nephrolithiasis and/or nephrocalcinosis (2,3).…”
Section: Introductionmentioning
confidence: 99%