Role of taurine in the pathogenesis of obesity

Murakami, Shigeru

doi:10.1002/mnfr.201500067

Cited by 131 publications

(104 citation statements)

References 116 publications

(204 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ingestion of taurine has been shown to alleviate metabolic diseases such as hyperlipidemia, diabetes, hypertension and obesity in animal models. Synthetic activity and concentration of taurine in adipose tissues and plasma have been shown to decrease in humans and animals during the development of obesity, suggesting a relationship between taurine deficiency and obesity [16]. …”

mentioning

confidence: 99%

Obesity and Taurine

Sattari¹,

Mashayekhi²

2015

AOWMC

View full text Add to dashboard Cite

mentioning

confidence: 99%

Obesity and Taurine

Sattari¹,

Mashayekhi²

2015

AOWMC

View full text Add to dashboard Cite

“…In addition, taurine has multiple biological effects, such as protection against liver cirrhosis and antioxidative, 27 anti-inflammatory, antiatherosclerotic, 28,29 and antiobesity effects. 30 Unfortunately, evidence that taurine supplementation reduces BP in human hypertension is inconclusive despite the fact that multiple experimental studies have demonstrated the hypotensive effect of taurine in different hypertensive animal models.The antihypertensive effect of taurine in humans has only been confirmed in a few clinical studies with small sample sizes (n=10-12) that were short term (7 days to 6 weeks). …”

mentioning

confidence: 99%

Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension

et al. 2016

View full text Add to dashboard Cite

P rehypertension is highly prevalent worldwide.1 It is estimated that ≈30% to 50% of the population have this condition. It frequently complicates other cardiometabolic risk factors and is closely associated with coronary heart disease, stroke, and renal dysfunction.2 Early intervention in prehypertension substantially prevents the incidence of hypertension and related damage to target organs. Currently, several strategies are used to treat prehypertension, including the incorporation of therapeutic lifestyle changes, such as healthy dietary intake and regular physical activity, as well as the use of antihypertensive drugs, such as an angiotensin II receptor blocker. Although these treatments improve prehypertension, poor compliance and limitations associated with antihypertensive medications prevent their application in the general population. Thus, there is an urgent need to identify reliable and accurate measures to prevent the development of prehypertension.Taurine (2-aminoethanesulfonic acid) is the most abundant, semiessential, sulfur-containing amino acid. It can be synthesized in vivo by cysteine in the presence of cysteine dioxygenase, 3 but taurine is mainly acquired from dietary sources, such as eggs, meat, and seafood. Hydrogen sulfide (H 2 S) is synthesized from 2 sulfur-containing amino acids, l-cysteine and l-methionine, by the 3 enzymes, cystathionine-γ-lyase (CSE), cystathionine-β-synthetase (CBS), and 3-mercaptopyruvate sulfurtransferase. 4 Taurine has several potentially beneficial cardiovascular effects that involve regulation of the nitric oxide system and endothelial function, 5,6 the renin-angiotensin-aldosteroneAbstract-Taurine, the most abundant, semiessential, sulfur-containing amino acid, is well known to lower blood pressure (BP) in hypertensive animal models. However, no rigorous clinical trial has validated whether this beneficial effect of taurine occurs in human hypertension or prehypertension, a key stage in the development of hypertension. In this randomized, double-blind, placebo-controlled study, we assessed the effects of taurine intervention on BP and vascular function in prehypertension. We randomly assigned 120 eligible prehypertensive individuals to receive either taurine supplementation (1.6 g per day) or a placebo for 12 weeks. Taurine supplementation significantly decreased the clinic and 24-hour ambulatory BPs, especially in those with high-normal BP. Mean clinic systolic BP reduction for taurine/placebo was 7.2/2.6 mm Hg, and diastolic BP was 4.7/1.3 mm Hg. Mean ambulatory systolic BP reduction for taurine/placebo was 3.8/0.3 mm Hg, and diastolic BP was 3.5/0.6 mm Hg. In addition, taurine supplementation significantly improved endothelium-dependent and endothelium-independent vasodilation and increased plasma H 2 S and taurine concentrations. Furthermore, changes in BP were negatively correlated with both the plasma H 2 S and taurine levels in taurine-treated prehypertensive individuals. To further elucidate the hypotensive mechanism, experimental studies were perfor...

show abstract

“…Taurine is involved in many physiological functions including osmoregulation, antioxidation, calcium modulation, and membrane stabilization 34) . An analysis of taurine transporter knockout mice suggests that taurine has a significant role in maintaining normal cellular function, with knockouts showing a premature aging phenotype 35) .…”

Section: Taurinementioning

confidence: 99%

“…This suggests that taurine has a similar mechanism of action as statins and adiponectin, both of which are CRM candidates. Interestingly, several studies have reported that taurine increases plasma adiponectin levels 34) . Moreover, it has been reported that taurine inhibits angiotensin II 38) , suggesting that taurine may have a similar effect as that of the ARBs.…”

Section: Taurinementioning

confidence: 99%

“…Taurine is used for the treatment of congestive heart failure and hyperbilirubinemia. Taurine also affects the function of the central nervous system, adipose tissue, and muscle, including in the heart, liver 34) and other organs that are also affected by CR. While there are some differences between taurine and CR in their effects on these organs, further research into the mechanisms of taurine action could reveal CRM functions.…”

Section: Taurinementioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of action of compounds that mimic beneficial effects of calorie restriction such as lifespan extension: Is taurine a promising candidate?

Nishizono

Wang

Watanabe

et al. 2017

JPFSM

View full text Add to dashboard Cite

More than 80 years ago, McCay and colleagues first reported that limiting the amount of food provided to experimental animals (i.e. calorie restriction or CR) prolongs their lifespan and suppresses the onset and progression of various age-related diseases. Today, CR remains the most reliable method of delaying aging in experimental animals, and research into its underlying molecular mechanisms is ongoing. CR has been reported to have anti-aging and life-extension effects on primates, with progress being made toward applications for humans. Studies on mechanisms underlying the onset and prevention of lifestyle-related diseases such as diabetes have elucidated the cellular signaling pathways that regulate energy metabolism, and commonalities have been discovered between the targets of existing diabetes drugs and the signaling pathways affected by CR. This finding has led to research into the discovery of drugs that have the anti-aging effects of CR in the absence of food intake limitations, namely CR mimetics (CRM). Several drugs have been reported to extend the lifespan of experimental organisms, which may thus have the potential to also extend human lifespan. In this article, we outline and compare those drugs that have been reported to date and discuss the possibility of taurine as a CRM, which is a topic of our ongoing research.

show abstract

Role of taurine in the pathogenesis of obesity

Cited by 131 publications

References 116 publications

Obesity and Taurine

Obesity and Taurine

Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension

Mechanisms of action of compounds that mimic beneficial effects of calorie restriction such as lifespan extension: Is taurine a promising candidate?

Contact Info

Product

Resources

About