Role of Telomeres and Telomerase in Cancer and Aging

Saretzki, Gabriele

doi:10.3390/ijms24129932

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…In addition to regulating telomere length (canonical function), telomerase and hTERT perform many other functions such as impact on proliferation (due to Wnt/β-catenin pathway or NF-kB and p65 pathway), cell survival, apoptotic resistance, adhesion, migration, stem cell renewal, inflammation, chromatin configuration and DNA repair, mitochondrial DNA protection and resistance to ionizing radiation (non-canonical functions) [209,210]. Thus, telomerase and hTERT were identified as potential therapeutic targets for cancer treatment [211].…”

Section: Ellagic Acid and Enabling Replicative Immortalitymentioning

confidence: 99%

Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Čižmáriková,

Michalková,

Mirossay

et al. 2023

Biomolecules

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Cancer is a complex and multifaceted disease with a high global incidence and mortality rate. Although cancer therapy has evolved significantly over the years, numerous challenges persist on the path to effectively combating this multifaceted disease. Natural compounds derived from plants, fungi, or marine organisms have garnered considerable attention as potential therapeutic agents in the field of cancer research. Ellagic acid (EA), a natural polyphenolic compound found in various fruits and nuts, has emerged as a potential cancer prevention and treatment agent. This review summarizes the experimental evidence supporting the role of EA in targeting key hallmarks of cancer, including proliferation, angiogenesis, apoptosis evasion, immune evasion, inflammation, genomic instability, and more. We discuss the molecular mechanisms by which EA modulates signaling pathways and molecular targets involved in these cancer hallmarks, based on in vitro and in vivo studies. The multifaceted actions of EA make it a promising candidate for cancer prevention and therapy. Understanding its impact on cancer biology can pave the way for developing novel strategies to combat this complex disease.

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Section: Ellagic Acid and Enabling Replicative Immortalitymentioning

confidence: 99%

Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Čižmáriková,

Michalková,

Mirossay

et al. 2023

Biomolecules

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“…In some instances, it is also discovered that aging and cancer have similar mechanisms. Genomic instability, telomere attrition, proteostasis loss, diminished nutrition sensing, altered metabolism, and epigenetic alterations are a few examples of these pathways [3,4]. Because cancer and aging are closely related, it is apparent that epigenetic factors influence both diseases' entire development and course.…”

Section: Introduction 1epigenetics Of Cancer In Relation To Agingmentioning

confidence: 99%

Aging and Age-Related Epigenetic Drift in the Pathogenesis of Leukemia and Lymphomas: New Therapeutic Targets

Allegra,

Caserta,

Mirabile

et al. 2023

Cells

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One of the traits of cancer cells is abnormal DNA methylation patterns. The idea that age-related epigenetic changes may partially explain the increased risk of cancer in the elderly is based on the observation that aging is also accompanied by comparable changes in epigenetic patterns. Lineage bias and decreased stem cell function are signs of hematopoietic stem cell compartment aging. Additionally, aging in the hematopoietic system and the stem cell niche have a role in hematopoietic stem cell phenotypes linked with age, such as leukemia and lymphoma. Understanding these changes will open up promising pathways for therapies against age-related disorders because epigenetic mechanisms are reversible. Additionally, the development of high-throughput epigenome mapping technologies will make it possible to identify the “epigenomic identity card” of every hematological disease as well as every patient, opening up the possibility of finding novel molecular biomarkers that can be used for diagnosis, prediction, and prognosis.

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Rolling Circle Amplification Integrating with Exonuclease-III-Assisted Color Reaction for Sensitive Telomerase Activity Analysis

Liu,

Zhao,

Zhang

et al. 2024

ACS Omega

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Telomerase activation can lead to the escape from cell senescence and immortalization, playing a crucial role in the growth and proliferation of cancer cells. Therefore, the detection of telomerase activity is essential for cancer diagnosis and treatment. Herein, we develop a novel ultrasensitive and visually detectable platform. By incorporation of exonuclease-III (Exo-III), this platform achieves dual signal amplification of rolling circle amplification products. Additionally, the colorimetric analysis of 3,3′,5,5′-tetramethylbiphenyl (TMB) chromogenic reaction system provides this approach with unique advantages such as simplicity, speediness, and sensitivity. The detection platform exhibits high sensitivity and specificity in actual sample testing, which aligns closely with results obtained using commercial kits. Moreover, it offers ease-of-use through visual determination by the naked eyes. This finding indicates that our proposed sensing method performs satisfactorily in detecting telomerase in real biological samples. Henceforth, we believe that this sensing platform holds great potential for clinical diagnosis and anticancer drug development.

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Role of Telomeres and Telomerase in Cancer and Aging

Abstract: Seventeen papers published in 2019 and early 2020 demonstrate the ongoing interest and research concerning telomeres and telomerase in aging and cancer [...]

Cited by 5 publications

References 29 publications

Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Aging and Age-Related Epigenetic Drift in the Pathogenesis of Leukemia and Lymphomas: New Therapeutic Targets

Rolling Circle Amplification Integrating with Exonuclease-III-Assisted Color Reaction for Sensitive Telomerase Activity Analysis

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