Role of testosterone in the treatment of hypoactive sexual desire disorder

Schwenkhagen, A.; Studd, John

doi:10.1016/j.maturitas.2009.02.011

Cited by 42 publications

(17 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is well known that sex hormones may influence brain functions via rapid, nongenomic mechanisms (3). In support of this concept, menstrual cycle studies and shortterm hormone interventions have shown consistent effects on mood and behavior (49,50). Furthermore, even a single dose of testosterone as mentioned previously has demonstrated significant effects on cognition in young women (32,33).…”

Section: Figurementioning

confidence: 59%

A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women

Kocoska-Maras

Zethraeus

Rådestad

et al. 2011

Fertility and Sterility

View full text Add to dashboard Cite

Section: Figurementioning

confidence: 59%

A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women

Kocoska-Maras

Zethraeus

Rådestad

et al. 2011

Fertility and Sterility

View full text Add to dashboard Cite

“…Hormone levels were not measured in the present series nor did we have a basal FSFI value. Although studies have reported that testosterone treatment may improve libido in women with low testosterone levels (Krapf and Simon 2009;Schwenkhagen and Studd 2009), the association of endogenous testosterone and sexual function in oophorectomised subjects remains a debatable matter (Spark 2005;Topnews 2009). Oestrogen HT improves sexual function in oophorectomised women by protecting vaginal epithelia and increasing vaginal lubrication.…”

Section: Discussionmentioning

confidence: 99%

Assessment of sexuality after hysterectomy using the Female Sexual Function Index

Rodríguez¹,

Chedraui²,

Schwager³

et al. 2012

Journal of Obstetrics and Gynaecology

View full text Add to dashboard Cite

“…46 Testosterone Postmenopausal women have lower levels of testosterone than premenopausal women, probably due to aging rather than menopause itself, since testosterone levels in women in their 40s are approximately half that of women in their 20s. 47 However, currently available assays have made it difficult to accurately measure testosterone levels in women, 48,49 and a large crosssectional study failed to show a significant relationship between testosterone levels and female sexual function. 50 Early studies established that testosterone therapy improved sexual function-primarily desire, arousal, and orgasmic response-in both naturally and surgically induced postmenopausal women.…”

Section: Hormone Therapymentioning

confidence: 99%

Low Sexual Desire — Is it All in Her Head? Pathophysiology, Diagnosis, and Treatment of Hypoactive Sexual Desire Disorder

Simon¹

2010

Postgraduate Medicine

View full text Add to dashboard Cite

Hypoactive sexual desire disorder (HSDD) is thought to be the most prevalent form of female sexual dysfunction (FSD), affecting up to 1 in 10 US women. Hypoactive sexual desire disorder is defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) as persistent or recurrent deficiency or absence of sexual fantasies and thoughts, and/or desire for, or receptivity to, sexual activity, which causes personal distress or interpersonal difficulties and is not caused by a medical condition or drug. This definition has recently received criticism and recommendations for changes encompass the inclusion of duration, intensity, and frequency, and the elimination of distress as a diagnostic criterion. More recently, it has been suggested that arousal and desire be combined into one disorder for the upcoming DSM-V. Causes of low desire include chronic medical conditions, medications, surgeries, and psychosocial factors, but not necessarily increased age; both pre- and postmenopausal women can have HSDD, although the frequency appears to vary by age. Sexual function requires the complex interaction of multiple neurotransmitters and hormones, both centrally and peripherally, and sexual desire is considered the result of a complex balance between inhibitory and excitatory pathways in the brain. For example, dopamine, estrogen, progesterone, and testosterone play an excitatory role, whereas serotonin and prolactin are inhibitory. Thus, decreased sexual desire could be due to a reduced level of excitatory activity, an increased level of inhibitory activity, or both. A number of validated self-report and clinician-administered instruments are available for assessing female sexual function; however, most have been used primarily in clinical research trials. The Decreased Sexual Desire Screener (DSDS) was developed for practicing clinicians who are neither trained nor specialized in FSD to assist in making an accurate diagnosis of generalized acquired HSDD. As our understanding of the pathophysiology of HSDD increases, it may become easier for physicians to identify and treat women with low sexual desire.

show abstract

Role of testosterone in the treatment of hypoactive sexual desire disorder

Cited by 42 publications

References 53 publications

A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women

A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women

Assessment of sexuality after hysterectomy using the Female Sexual Function Index

Low Sexual Desire — Is it All in Her Head? Pathophysiology, Diagnosis, and Treatment of Hypoactive Sexual Desire Disorder

Contact Info

Product

Resources

About