Role of TGF-β1 in renal parenchymal scarring following childhood urinary tract infection

Cotton, Shirley A.; Gbadegesin, Rasheed; Williams, Shelley; Brenchley, Paul; Webb, Nicholas J.A.

doi:10.1046/j.1523-1755.2002.00110.x

Cited by 69 publications

(66 citation statements)

References 34 publications

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“…First, the existence of the genetic heterogeneity results from the geographical environment and living habits of subject, which influence the frequency distribution of the crowd gene. Some studies have shown that the difference in C509T gene distribution between European and Asian countries is statistically significant (Cotton et al, 2002;Holla et al, 2002;Chen et al, 2005). Second, the clinical characteristics of participants -for example, age and years from onset, male predominance -may lead to different outcomes.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis demonstrates association of the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy in European but not in Asian populations

Wang

Li²,

Feng³

2013

Genet. Mol. Res.

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ABSTRACT. There are conflicting reports associating the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy. We investigated this association through a meta-analysis. Case-control studies were searched up to January 2012; the genotype frequencies in the control group were found to be consistent with Hardy-Weinberg equilibrium. Publication bias was tested by funnel plot and the Egger regression test. Eight studies, comprising 1364 cases and 1483 controls, were included. Significant heterogeneity was observed (χ 2 = 18.29, P = 0.01). Under the random-effects model, the overall odds ratio (OR) was 1.01 [95% confidence interval (95%CI) = 0.74-1.38; P = 0.94]. In the subgroup analysis based on ethnicities, no significant effect was observed in the Asian descent groups (five comparisons, OR = 0.78; 95%CI = 0.53-1.15; moderate heterogeneity between studies). However, an association was observed in the European descent groups (OR = 1.5; 95%CI = 1.15-1.96; P = 0.003; no significant heterogeneity between studies). There was no evidence of publication bias according to funnel plot and the Egger regression test (a = -2.16, P = 0.23). There was heterogeneity between studies and no clear evidence of an association between the TGF-β1 gene -C509T polymorphism and susceptibility to IgA nephropathy in the worldwide population. Subgroup analysis suggests that the TGF-β1 gene -C509T polymorphism would not be a risk factor for IgA nephropathy in Asians but might play a role in Europeans. More studies are required for definitive conclusions.

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Section: Discussionmentioning

confidence: 99%

Meta-analysis demonstrates association of the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy in European but not in Asian populations

Wang

Li²,

Feng³

2013

Genet. Mol. Res.

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“…Polymorphisms within the VEGF and TGF-␤1 genes have often been linked to overproduction of these proteins, and both predisposition to and sequelae of progressive renal disease (13)(14)(15). Several polymorphisms of the VEGF and TGF-␤1 genes have been identified, and there are reports on the association of TGF-␤1 gene polymorphism and renal scarring (15,16).…”

mentioning

confidence: 99%

“…Several polymorphisms of the VEGF and TGF-␤1 genes have been identified, and there are reports on the association of TGF-␤1 gene polymorphism and renal scarring (15,16). On the other hand, there is no published study on the link of VEGF gene polymorphism to renal scar formation, despite of the importance of hypoxia and angiogenesis in the scar formation.…”

mentioning

confidence: 99%

Genetic Control of VEGF and TGF-β1 Gene Polymorphisms in Childhood Urinary Tract Infection and Vesicoureteral Reflux

et al. 2007

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ABSTRACT:We investigated whether genetic polymorphisms of vascular endothelial growth factor (VEGF) and transforming growth factor-␤1 (TGF-␤1), potential candidate genes in the pathogenesis of urinary tract infection (UTI) and vesicoureteral reflux (VUR), are associated with the susceptibility to UTI and VUR, and renal scarring. We recruited 89 controls and 86 UTI and 58 VUR children. The UTI group was subdivided into two groups according to renal scarring. Two polymorphisms of VEGF and three of TGF-␤1 genes were investigated by using PCR-restriction fragment length polymorphism analysis. In both UTI and VUR groups, there was an increase in frequency of the VEGF -460 CC (control, 4.3; UTI, 15.9; VUR, 17.8%; p Ͻ 0.05), TGF-␤1 -509 CC (control, 8.7; UTI, 34.6; VUR, 35.1%; p Ͻ 0.001), and TGF-␤1 -800 GG genotypes (control, 19.1; UTI, 40.5; VUR, 40.4%; p Ͻ 0.05). An increase in the TGF-␤1 ϩ869 CC (scar-positive, 35.4; scar-negative, 10.3%; p Ͻ 0.05) and a decrease in the ϩ869 TC genotype (scar-positive, 29.2; scarnegative, 55.2%; p Ͻ 0.05) were observed in the scar-positive subjects. There were no differences in ϩ405 VEGF genotype frequencies. The VEGF T-460C and the TGF-␤1 C-509T, G-800A, and T869C polymorphisms could be genetic markers of the process of UTI and VUR. (Pediatr Res 62: 183-187, 2007)

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“…Solari et al (2005) documented that the risk of reflux nephropathy was higher in patients with -509CT and Leu10Pro genotypes. Khalil et al (2005) showed that homozygosity for -509T and Arg25 resulted in more rapid progression of renal failure whereas patients with -800GA genotype were less susceptible to renal scarring (Cotton et al, 2002). Numerous studies confirmed a significant participation of TGF-in pathogenesis of obstructive nephropathy (Blom et al, 2001;Chevalier, 2004;Duncan et al, 1999;Kaneto et al, 1999;Klahr & Morrissey, 1998, 2002, 2003Sato et al, 2003;Schnaper et al, 2003).…”

Section: Transforming Growth Factor (Tgf-)mentioning

confidence: 99%

“…In addition, it increases expression of TIMPs. This contributes to depressed activity of MMP and stabilization of extracellular matrix (Boettinger & Bitzer, 2002;Boettinger et al, 1997;Broder et al, 1994;Cotton et al, 2002;Deng et al, 2006;Fan et al, 1999;Goumneos et al, 2002;Guo et al, 1997;Jahnukainen et al, 2005;Korzon et al, 2004;Lane et al, 2002;Liapis, 2003). Poncelet & Schnaper (1998) documented that TGF-stimulates production of collagen I, III and IV by mesangial cells.…”

Section: Transforming Growth Factor (Tgf-)mentioning

confidence: 99%

Post-Inflammatory Nephropathy

Bieniaś¹,

Zajączkowska²,

Borzęcka³

et al. 2011

Urinary Tract Infections

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Role of TGF-β1 in renal parenchymal scarring following childhood urinary tract infection

Abstract: There is an association between the TGF-beta1 -800 GA, -509 TT and Leu10-->Pro CT genotypes and the presence or absence of RPS. The low TGF-beta1 producer status of the -800 GA genotype may protect against the development of a pro-fibrotic pathology.

Cited by 69 publications

References 34 publications

Meta-analysis demonstrates association of the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy in European but not in Asian populations

Meta-analysis demonstrates association of the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy in European but not in Asian populations

Genetic Control of VEGF and TGF-β1 Gene Polymorphisms in Childhood Urinary Tract Infection and Vesicoureteral Reflux

Post-Inflammatory Nephropathy

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