Role of the alternative oxidase in limiting superoxide production by plant mitochondria

Purvis, Albert C.

doi:10.1111/j.1399-3054.1997.tb03468.x

Cited by 210 publications

(73 citation statements)

References 25 publications

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“…Based on the fact that the inhibition of PUMP activity by the addition of ATP and BSA increases mitochondrial H 2 O 2 generation, it has been suggested that PUMP activity decreases the production of mitochondrial reactive oxygen species [140]. A similar regulatory function has been postulated for the alternative oxidase [141,142] and for rat UCP2, which could decrease the formation of reactive oxygen species under stress conditions by preventing overreduction of the respiratory chain [143]. Finally, we can postulate that plant UCPs could maintain the energy balance of the cell via the downregulation of ATP production and elimination of energy excess.…”

Section: Review Articlementioning

confidence: 97%

Plant mitochondrial carriers: an overview

Laloi

1999

Cellular and Molecular Life Sciences (CMLS)

107

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In the two last decades, biochemical studies using mitochondrial swelling experiments or direct solute uptake in isolated mitochondria have lead to the identification of different transport systems at the level of the plant mitochondrial inner membrane. Although most of them have been found to have similar features to those identified in animal mitochondria, some differences have been observed between plant and animal transporters. More recently, molecular biology studies have revealed that most of the mitochondrial exchanges are performed by nuclear encoded proteins, which form a superfamily. Members of this family have been reported in animals, yeast as well as plants. This review attempts to give an overview of the present knowledge concerning the biochemical and molecular characterisation of plant members of the mitochondrial carrier family and, when possible, a comparison with carriers from other organisms.

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Section: Review Articlementioning

confidence: 97%

Plant mitochondrial carriers: an overview

Laloi

1999

Cellular and Molecular Life Sciences (CMLS)

107

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“…3,4 Though mitochondria are the major source of ROS production in mammalian cells, in green tissues its contribution for ROS is not effective. 5 The mitochondrial electron transport chain can produce ROS, which can transfer a single electron to oxygen and produce O 2 -. The mitochondrial alternative oxidase (AOX) catalyses the O 2 -dependent oxidation of ROS.…”

Section: Production Of Reactive Oxygen Intermediates In Plantsmentioning

confidence: 99%

Reactive oxygen species generation and signaling in plants

Tripathy

Oelmüller²

2012

Plant Signaling & Behavior

616

304

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“…One proposed function of the AP is to prevent the UQ pool from becoming overly reduced, which can result in production of active/reactive oxygen species (ROS; Boveris and Cadenas, 1982;Purvis, 1997;Møller, 2001). Transgenic tobacco plants over-expressing tobacco AOX show lower production of ROS in the mitochondria (Maxwell et al, 1999) and the tobacco Aox1 gene is induced by application of hydrogen peroxide (Maxwell et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

A reporter gene system used to study developmental expressionof alternative oxidase and isolate mitochondrial retrograde regulationmutants in Arabidopsis

2005

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Perturbation of mitochondrial function causes altered nuclear gene expression in plants. To study this response, called mitochondrial retrograde regulation, and developmental gene expression, a transgenic Arabidopsis thaliana (Col-0) line containing a firefly luciferase gene controlled by a promoter region of the Arabidopsis alternative oxidase 1a gene (AtAOX1a) was created. The transgene and the endogenous gene were developmentally induced in young cotyledons to a level higher than in older cotyledons and leaves. Analysis of transgene expression suggests that this is true for emerging leaves as well. Antimycin A (AA), a mitochondrial electron transport chain inhibitor, and monofluroacetate (MFA), a TCA cycle inhibitor, induced expression of the transgene and the endogenous gene in parallel. The following comparative responses of the transgene to inhibitors were observed: (a) the response in cotyledons to AA treatment differed greatly in magnitude from the response in leaves; (b) the induction kinetics in cotyledons following MFA treatment differed greatly from the kinetics in leaves; and (c) the induction kinetics following MFA treatment differed from the kinetics of AA in both leaves and cotyledons. The transgenic line was used in a genetic screen to isolate mutants with greatly decreased transgene and AtAOX1a induction in response to AA. Some of these mutant lines showed greatly decreased induction by MFA, but one did not. Taken altogether, the data provide genetic evidence that suggests that induction of the AtAOX1a gene by distinct mitochondrial perturbations are via distinct, but overlapping signaling pathways that are tissue specific.

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Role of the alternative oxidase in limiting superoxide production by plant mitochondria

Cited by 210 publications

References 25 publications

Plant mitochondrial carriers: an overview

Plant mitochondrial carriers: an overview

Reactive oxygen species generation and signaling in plants

A reporter gene system used to study developmental expressionof alternative oxidase and isolate mitochondrial retrograde regulationmutants in Arabidopsis

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