1992
DOI: 10.1016/s0021-9258(18)42309-5
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Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement.

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Cited by 463 publications
(299 citation statements)
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References 48 publications
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“…Second, it facilitates PKa-FXII or FXIIa-FXII complex formation by bringing protease and substrate into proximity. This "template mechanism" 31,32 is also relevant to complex formation between FXIIa and its substrates PK and factor XI. 33 The goal of the present study was to investigate the contributions of FXII heavy chain domains (HCDs) to FXII activation, and FXIIa activation of PK.…”
Section: Discussionmentioning
confidence: 99%
“…Second, it facilitates PKa-FXII or FXIIa-FXII complex formation by bringing protease and substrate into proximity. This "template mechanism" 31,32 is also relevant to complex formation between FXIIa and its substrates PK and factor XI. 33 The goal of the present study was to investigate the contributions of FXII heavy chain domains (HCDs) to FXII activation, and FXIIa activation of PK.…”
Section: Discussionmentioning
confidence: 99%
“…Without close monitoring and control of bloodstream heparin levels, potentially fatal heparin overdose effects, such as internal hemorrhaging, can occur. 1 Various chemical sensors for heparin detection have been developed using appropriate signal transductions such as spectroscopy, 2 voltammetry, 3 quartz microbalance 4 and conductometry. 5 Potentiometric sensors are generic and highly successful approaches to chemical sensing, and polyion-selective membrane electrodes have shown to be very promising in biomedical analysis.…”
Section: Introductionmentioning
confidence: 99%
“…1 At the end of the reaction, fondaparinux is released without any conformational or chemical changes, and can be used again to bind to another antithrombin molecule. 2 This molecule does not bind to plasma proteins and therefore has a predictive pharmacological effect. Its half-life in plasma is 17 hours and is dose-independent.…”
Section: Pentasaccharidementioning
confidence: 99%