Role of the Apparent Diffusion Coefficient in the Prediction of Response to Neoadjuvant Chemotherapy in Patients With Locally Advanced Breast Cancer

Bufi, Enida; Belli, Paolo; Costantini, Melania; Cipriani, Antonio; Matteo, Marialuisa Di; Bonatesta, Angelo; Franceschini, Gianluca; Terribile, Daniela; Mulè, Antonino; Nardone, Luigia; Bonomo, Lorenzo

doi:10.1016/j.clbc.2015.02.002

Cited by 49 publications

(43 citation statements)

References 43 publications

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“…Additionally, pretreatment ADC measures may hold prognostic value to help identify patients who will best respond to neoadjuvant treatments. Three large scale studies of women with locally advanced breast cancer undergoing neoadjuvant chemotherapy (n = 519 women total) each showed low pretreatment tumor ADC values to be predictive of pathological complete response for triple‐negative tumors, with more variable findings in luminal and HER2 + subtypes . However, there is wide variability in the current literature as to the utility of DWI to monitor breast cancer therapy, likely due to differences in study design (including treatment timings of imaging, patient characteristics, and ADC measurement approaches), and further investigation is needed to validate ADC as a predictive biomarker of therapeutic efficacy.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Diffusion-weighted breast MRI: Clinical applications and emerging techniques

Partridge

Nissan²,

Rahbar

et al. 2016

J. Magn. Reson. Imaging

278

258

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Diffusion weighted MRI (DWI) holds potential to improve the detection and biological characterization of breast cancer. DWI is increasingly being incorporated into breast MRI protocols to address some of the shortcomings of routine clinical breast MRI. Potential benefits include improved differentiation of benign and malignant breast lesions, assessment and prediction of therapeutic efficacy, and non-contrast detection of breast cancer. The breast presents a unique imaging environment with significant physiologic and inter-subject variations, as well as specific challenges to achieving reliable high quality diffusion weighted MR images. Technical innovations are helping to overcome many of the image quality issues that have limited widespread use of DWI for breast imaging. Advanced modeling approaches to further characterize tissue perfusion, complexity, and glandular organization may expand knowledge and yield improved diagnostic tools.

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Section: Clinical Applicationsmentioning

confidence: 99%

Diffusion-weighted breast MRI: Clinical applications and emerging techniques

Partridge

Nissan²,

Rahbar

et al. 2016

J. Magn. Reson. Imaging

278

258

View full text Add to dashboard Cite

show abstract

“…First, pre-treatment ADC measures may improve prognostic ability to identify which patients will best respond to neoadjuvant treatments. In women with triple-negative disease (ER, PR, and HER2-negative) undergoing neoadjuvant chemotherapy, several large studies have observed low pre-treatment tumor ADC values to be associated with pathological complete response [36, 45, 46]. Second, post-treatment DWI may provide a means to accurately assess extent of residual disease prior to surgery.…”

Section: Clinical Applicationsmentioning

confidence: 99%

DWI in the Assessment of Breast Lesions

Partridge

Amornsiripanitch

2017

Topics in Magnetic Resonance Imaging

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Diffusion-weighted MRI (DWI) holds promise to address some of the shortcomings of routine clinical breast MRI and to expand the capabilities of imaging in breast cancer management. DWI reflects tissue microstructure, and provides unique information to aid in characterization of breast lesions. Potential benefits under investigation include improving diagnostic accuracy and guiding treatment decisions. As a result, DWI is increasingly being incorporated into breast MRI protocols and multicenter trials are underway to validate single institution findings and to establish clinical guidelines. Advancements in DWI acquisition and modeling approaches are helping to improve image quality and extract additional biologic information from breast DWI scans, which may extend diagnostic and prognostic value.

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“…41 Furthermore, breast cancer patients with lower ADC prior to the initiation of NAT were more likely to exhibit a decrease in tumor volume during treatment. 42–44 The predictive value of ADC has been shown to be further strengthened based on breast cancer subtype stratification. 76,77 …”

Section: Emerging Strategiesmentioning

confidence: 99%

Imaging Considerations and Interprofessional Opportunities in the Care of Breast Cancer Patients in the Neoadjuvant Setting

Sorace¹,

Harvey²,

Syed³

et al. 2017

Seminars in Oncology Nursing

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Objective To discuss standard-of-care and emerging imaging techniques employed for screening and detection, diagnosis and staging, monitoring response to therapy, and guiding cancer treatments. Data Sources Published journal articles indexed in the National Library of Medicine database and relevant websites. Conclusion Imaging plays a fundamental role in the care of cancer patients and specifically, breast cancer patients in the neoadjuvant setting, providing an excellent opportunity for interprofessional collaboration between oncologists, researchers, radiologists and oncology nurses. Quantitative imaging strategies to assess cellular, molecular, and vascular characteristics within the tumor is needed to better evaluate initial diagnosis and treatment response. Implications for nursing practice Nurses caring for patients in all settings must continue to seek education on emerging imaging techniques. Oncology nurses provide education about the test, ensure the patient has appropriate pre testing instructions, and manage patient expectations about timing of results availability.

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Role of the Apparent Diffusion Coefficient in the Prediction of Response to Neoadjuvant Chemotherapy in Patients With Locally Advanced Breast Cancer

Cited by 49 publications

References 43 publications

Diffusion-weighted breast MRI: Clinical applications and emerging techniques

Diffusion-weighted breast MRI: Clinical applications and emerging techniques

DWI in the Assessment of Breast Lesions

Imaging Considerations and Interprofessional Opportunities in the Care of Breast Cancer Patients in the Neoadjuvant Setting

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