Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis

Vogeley, Christian; Esser, Charlotte; Tüting, Thomas; Krutmann, Jean; Haarmann‐Stemmann, Thomas

doi:10.3390/ijms20236005

Cited by 66 publications

(76 citation statements)

References 188 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In healthy skin, exposure to urban PM has been associated with accelerated extrinsic aging [40][41][42], its clinical symptoms being pigment spot formation, coarse wrinkle development, and elastosis [43]. Further evidence from epidemiological, clinical studies, and in vitro studies, and aging mechanisms have been reviewed [19,[44][45][46], all indicating the generation of free radicals, the activation of aryl hydrocarbon receptor signaling, the induction of inflammatory cascade, and finally the impairment of the skin barrier.…”

Section: Epidemiologymentioning

confidence: 99%

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

126

116

View full text Add to dashboard Cite

Background: Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have been reported for urbanized areas, particularly linked to the presence of airborne nano-sized and ultrafine particles. Main text: To date, most of the research studies did focus on the adverse effects of air pollution on the human cardiovascular and respiratory systems. Although the skin is in direct contact with air pollutants, their damaging effects on the skin are still under investigation. Epidemiological data suggested a correlation between exposure to air pollutants and aggravation of symptoms of chronic immunological skin diseases. In this study, a systematic literature review was conducted to understand the current knowledge on the effects of airborne particulate matter on human skin. It aims at providing a deeper understanding of the interactions between air pollutants and skin to further assess their potential risks for human health. Conclusion: Particulate matter was shown to induce a skin barrier dysfunction and provoke the formation of reactive oxygen species through direct and indirect mechanisms, leading to oxidative stress and induced activation of the inflammatory cascade in human skin. Moreover, a positive correlation was reported between extrinsic aging and atopic eczema relative risk with increasing particulate matter exposure.

show abstract

Section: Epidemiologymentioning

confidence: 99%

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

126

116

View full text Add to dashboard Cite

show abstract

“…Previous reports demonstrated the stimulation of MMP-1 expression through the activation of the AhR pathway in melanoma cells, vascular smooth muscle cells, and urothelial carcinoma cells (Ishida et al, 2010;Meng et al, 2009;Vogeley et al, 2019). To find out whether B[a]PDE is dependent on AhR to activate the MAPK pathways, we determined MMP-1 expression in HaCaT cells treated with B[a]PDE in the presence of α-Naphthoflavone (α-NF), a classical AhR antagonist.…”

Section: Mmp-1 Expression and Phosphorylation Of Erk P38 Jnk And Thmentioning

confidence: 99%

Identification of the MMP-1 regulation mechanism of benzopyrene, polycyclic aromatic hydrocarbons in foods

Han¹,

Kang²

2020

Korean J. Food Preserv.

View full text Add to dashboard Cite

Benzo[a]pyrene-7,8-diol-9,10-epoxide (B[a]PDE) has been reported to cause various pathological lesions in humans via activation of the aryl hydrocarbon receptor (AhR) pathway. However, the molecular mechanism by which B[a]PDE regulates signaling pathways during skin aging remains unclear. The present study investigated the effects of B[a]PDE on the expression of matrix metalloproteinase-1 (MMP-1), which is a major enzyme responsible for collagen damage, and its regulation of skin aging-related signaling pathways in HaCaT human keratinocyte cells. MMP-1 expression was increased by B[a]PDE treatment, and mitogen-activated protein kinase (MAPK) inhibitors suppressed B[a]PDE-induced MMP-1 expression. Furthermore, a-naphthoflavone (a-NF, AhR antagonist), PP2 (c-Src inhibitor), and gefitinib (EGFR inhibitor) attenuated the B[a]PDE-induced phosphorylation of and p38 and their upstream kinases such as c-Raf, MEK, and MKK3/6. These results suggest that AhR, c-Src, and epidermal growth factor receptor (EGFR) activations are necessary for B[a]PDE-induced MMP-1 upregulation by modulation of MAPK pathway activation. B[a]PDE also stimulates the phosphorylation of ERK via c-Src-dependent EGFR transactivation. These results demonstrate a novel mechanism by which B[a]PDE induces MMP-1 expression through the activation of AhR, c-Src, and EGFR in non-genetic pathways. Thus, it is indicated that the molecular mechanisms of MMP-1 expression by B[a]PDE-activated AhR play an important role in promoting skin aging.

show abstract

“…Alternatively, the ligand-AHR can induce the AHRR gene which inactivates the AHR by transcribing corepressors [47] . Other inhibition of AHR is regulated by expulsion of the ligand-AHR from the nucleus for degradation in the cytoplasm.…”

Section: Mechanism Of Detoxification: the Ahrmentioning

confidence: 99%

“…After release from the initial cytoplasmic AHR complex, the chaperone protein oncogene cSRC binds to the epidermal growth factor receptor (EGFR), activating the cSRC protein kinase to induce carcinogenesis. (Modified from Figure 1 of Vogeley et al [47] with the author's consent.). cSRC: "cellular sarcoma", photo oncogene tyrosine-protein kinase; ARNT: AHR nuclear translocator many as non-smoking women [53] .…”

Section: Indoor Pollutionmentioning

confidence: 99%

Environmental aging of the skin: new insights

Burke¹

2020

Plast Aesthet Res

View full text Add to dashboard Cite

The appearance of aging is determined primarily by extrinsic factors through exposure to environmental sunlight and airborne pollution. That solar ultraviolet B (λ = 290-320 nm) directly causes photoaging (with wrinkles, dryness, and mottled pigmentation) and skin cancer has been recognized for decades; the contribution by ultraviolet A (λ = 320-400 nm) was only more recently understood. New research further implicates visible light (λ = 400-700 nm) as well as the heat rays of infrared radiation (λ > 800 nm). Particularly in urban environments, airborne pollutants such as ozone (O 3), polycyclic aromatic hydrocarbons, particulate matter (PM) in smog, and tobacco smoke contribute to photoaging and skin cancer. Furthermore, exposure simultaneously to both solar ultraviolet (UV) and these pollutants results in even greater synergistic damage. The volatile pollutants generate reactive oxygen species which oxidize surface lipids leading to deeper damaging inflammatory reactions. PM carries high concentrations of environmental organic compounds and trace metals. These pollutant-laden particles deliver toxins to the skin transcutaneously through hair follicles and through the blood after respiratory inhalation. The predominant natural mechanism of clearing these xenobiotic chemicals is through the ligandactivated transcription factor the arylhydrocarbon receptor (AHR) found on all skin cells. AHR activity regulates keratinocyte differentiation and proliferation, maintenance of epidermal barrier function, melanogenesis, and immunity. With chronic activation by UV exposure and pollutants, AHR signaling contributes to both extrinsic aging and carcinogenesis.

show abstract

Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis

Cited by 66 publications

References 188 publications

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Identification of the MMP-1 regulation mechanism of benzopyrene, polycyclic aromatic hydrocarbons in foods

Environmental aging of the skin: new insights

Contact Info

Product

Resources

About