Role of the Biomimetic Scaffolds in the Regeneration of Articular Tissue in Deep Osteochondral Defects in a Rabbit Model

Abstract

The ability of damaged articular cartilage to recover with normal hyaline cartilage is limited. Our aim was to study the mechanism of in vivo cartilage repair in case of severe osteochondral lesions using a three-dimensional matrix implanted without any preseeded cells in the osteochondral defect in a rabbit model. According to the ICRS scores from macroscopic observations of the femoral condyles, the average scores in the scaffold groups were higher than those in the control groups at every time (P[0.001). Histological examination of the ostheochondral defects, revealed regeneration of new tissue with hyaline-like cartilage features only in matrix groups. At twelve weeks from implantation, complete filling of the defect with hyaline cartilage with a tendency of mineralization and the absence of implant material is observed. The superficial area of the defect is completely covered with hyaline-like cartilage. The scaffold used leaded to the regeneration of articular tissue with an ordered histoarchitecture.

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

“…The problem in early stage intervention is chiefly an inability to effectively regenerate articular cartilage [ 5 ] and the demand for osteochondral implants with tissue-regenerative capabilities has never been stronger. Devices are constantly being developed in an effort to address this currently unmet need with varying degrees of success [ 6 , 7 ]. The challenges and current device technologies to address regeneration have been recently reviewed for both articular cartilage [ 8 ] and the osteochondral interface [ 9 ].…”

“…It is imperative to gather as much information as possible from these studies, both to test the product with maximum scrutiny, and to limit the number of animals utilised due to financial and ethical considerations. In addition to scoring systems of the defect site, retrieved explants will typically undergo destructive 2D histological analysis to determine the type and quality of tissue formed [ 6 ]. With the advent of high-resolution three-dimensional imaging techniques, such as micro-computed tomography (micro-CT), comes the potential to carry out volumetric morphological analysis as a complimentary technique to histology.…”

Association of Neutrophil to Lymphocyte Ratio with Disease Severity and Joint Effusion in Patients with Early Stage Knee Osteoarthritis

“…A biomarker for early osteoarthritis highly corelated with clinical severity would be of great use for developing new treatments in early stages and for treatment follow up. Physical and chemical structure of joint have a great influence in disease progression and in the development of new types of treatments [22][23][24].…”

Cross-cultural adaptation and validation of the Romanian International Knee Documentation Committee—subjective knee form

“…Treatment of symptomatic knees with meniscus tears can be controversial, however it is still one of the most routinely performed orthopedic surgical procedure (Grevnerts, Terwee & Kvist, 2015;Beaufils et al, 2017;Todor, Caterev & Nistor, 2016). Cartilage surgery is still under development, with cautiously optimistic predictions for the future (Fodor et al, 2018). The transition from cartilage defects and meniscus tears to early OA is many times difficult.…”