Role of the Cardiophrenic Lymph Node Status After Neoadjuvant Chemotherapy in Primary Advanced Ovarian Cancer

Luengas-Wuerzinger, Veronica; Rawert, Friederike; Spee, Sabrina Classen-von; Baransi, Saher; Schuler, Esther; Carrizo, Katharina; Mallmann, Peter; Lampe, B.

doi:10.21873/anticanres.15317

Cited by 2 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More than 70% of OC patients were diagnosed as late stage because of the insidious progress and not obvious symptoms early, which leads to the 5-year survival rate is only 30% -40% [4]. The issue of LNM in OC has a particular interest among gynecological oncologists worldwide, because the LNM was with high occurrence and would affect the prognosis of OC [1,12,13,14]. Nasioudis et al have found that the rate of LNM was about 3.3% -14% in early OC and as high as 40% ~ 73.7% in late OC [15,16].…”

Section: Discussionmentioning

confidence: 99%

A Novel Clinical Nomogram for Predicting Lymph Node Metastasis in Ovarian Cancer: A SEER Analysis and External Validation in a Tertiary Center

Zhang¹,

Ren²

2021

Preprint

View full text Add to dashboard Cite

Introduction The aim of the study is to investigate the risk factors for developing lymph node metastases (LNM) in cases diagnosed as a presumed early-stage ovarian carcinoma (OC). Methodology Information of patients who had been diagnosed as OC in 2018 was obtained from the SEER database. We enrolled 104 OC patients in General Hospital of Northern Theatre Command for external validation. A logistic regression was conducted to determine the independent predictors for LNM, which were used for establishing a nomogram. In order to evaluate the reliability of nomogram, we applied a receiver operating characteristic curve (ROC) analysis, calibration curves and plotted decision curves. Results We found that age(≥70, OR=0.544, p=0.022), histology type (Mucinous carcinoma, OR=0.390, p=0.001; Endometrioid carcinoma, OR=7.946, p=0.053; Others, OR=2.400, p=0.040), histology grade (Grade II, OR=2.423, p=0.028; Grade III, OR=1.982, p=0.152; Grade IV, OR=1.594, p=0.063) and preoperative serum CA125 level (positive, OR=2.236, p=0.001) were all significant predictors of LNM. The AUC of the model training cohort, internal validation cohort, and external validation cohort were 0.78, 0.79 and 0.76 respectively. The calibration curves showed that the predicted outcome fitted well to the observed outcome in the training cohort (p=0.825) internal validation cohort (p=0.503), and external validation cohort (p=0.108). The decision curves showed the nomogram had more benefits than the All or None scheme if the threshold probability is >50% and <100% in training cohort and internal validation cohort, >30% and <90% in the external validation cohort. Conclusion The multivariate logistic regression showed that age, histology type, histology grade and preoperative serum CA125 level were all significant predictors of LNM. The nomogram established using the above variables had great performance for clinical applying.

show abstract

Section: Discussionmentioning

confidence: 99%

A Novel Clinical Nomogram for Predicting Lymph Node Metastasis in Ovarian Cancer: A SEER Analysis and External Validation in a Tertiary Center

Zhang¹,

Ren²

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Enlarged cardiophrenic lymph nodes are found in 10.5-62% of patients with advanced epithelial ovarian cancer, depending on the radiological size classification of a pathological node. [10][11][12][13][14] There is no current consensus regarding which radiological short axis cardiophrenic lymph nodes length should be considered pathological, with current cut-off values varying from 5 to 10 mm. 10 11 13 15 16 This lack of standard classification makes prognostication and diagnosis challenging.…”

Section: Imagingmentioning

confidence: 99%

Cardiophrenic lymph nodes in advanced ovarian cancer

Agusti,

Bonaldo,

Kahn

et al. 2024

International Journal of Gynecological Cancer

View full text Add to dashboard Cite

Epithelial ovarian cancer most commonly presents at advanced stages, and prognosis is influenced by residual disease following cytoreduction. The significance of cardiophrenic lymph node resection at the time of cytoreductive surgery in advanced ovarian cancer remains a topic of debate. Enlarged cardiophrenic lymph nodes are detected through high-resolution imaging; however, the optimal imaging technique in determining feasibility of node resection remains uncertain. Similarly, the impact of excision of cardiophrenic lymph nodes on progression-free and overall survival remains elusive. The indications for resection of cardiophrenic lymph nodes are not addressed in standard ovarian cancer guidelines. Patients with cardiophrenic lymph nodes exceeding 1 cm in size may be considered for resection if complete intra-abdominal cytoreduction is feasible to no gross residual. The surgical approach might be either by open access or by video-assisted thoracoscopic surgery (minimally invasive approach), and major complications following cardiophrenic lymph nodes resection are low. Pathological cardiophrenic lymph nodes are associated with a poorer overall prognosis and can serve as a prognostic parameter; however, the therapeutic benefit of cardiophrenic lymph nodes resection remains inconclusive.

show abstract

Role of the Cardiophrenic Lymph Node Status After Neoadjuvant Chemotherapy in Primary Advanced Ovarian Cancer

Cited by 2 publications

References 23 publications

A Novel Clinical Nomogram for Predicting Lymph Node Metastasis in Ovarian Cancer: A SEER Analysis and External Validation in a Tertiary Center

A Novel Clinical Nomogram for Predicting Lymph Node Metastasis in Ovarian Cancer: A SEER Analysis and External Validation in a Tertiary Center

Cardiophrenic lymph nodes in advanced ovarian cancer

Contact Info

Product

Resources

About