Role of the Chalcogen (S, Se, Te) in the Oxidation Mechanism of the Glutathione Peroxidase Active Site

Bortoli, Marco; Torsello, Mauro; Bickelhaupt, F. Matthias; Orian, Laura

doi:10.1002/cphc.201701128

Cited by 2 publications

(1 citation statement)

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“…[64] The mechanism of oxidation of the tellurium mutant of human GPx4 (Tec-GPx) has been in silico investigated and compared with that of Sec-GPx and Cys-GPx in order to establish the role of the chalcogen atom. [65] For Cys-and Sec-containing enzymes the study validates a mechanism proceeding through charge-separated intermediates with a thiolate or a selenolate center, respectively. Conversely, because of the fact that the tellurium hydrogen bond is not polarised, Tec-GPx the study suggests a catalytic path involving the direct oxidation of the tellurol moiety, leading to a telluroxide intermediate.…”

Section: Telluroproteinsmentioning

confidence: 63%

Tellurium-containing Thiol-peroxidase-like Antioxidants and their Catalytic Mechanism

Tanini

Capperucci

2023

CCB

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The development of novel small molecules with effective catalytic antioxidant properties is highly sought after. A wide array of structurally diverse selenium- and tellurium-containing glutathione peroxidase mimics have been studied over the past two decades. Within this arena, organotellurium compounds generally exhibit higher catalytic properties with respect to selenium-containing analogues. Different mechanisms accounting for the thiol-peroxidase-like activity of various classes of organotellurium derivatives have been proposed. This review document develops this area and provides an overview of the catalytic mechanisms proposed for the various classes of tellurium-containing thiol-peroxidase-like-catalysts.

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Section: Telluroproteinsmentioning

confidence: 63%