Role of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes

Duangjit, Sureewan; Pamornpathomkul, Boonnada; Opanasopit, Praneet; Rojanarata, Theerasak; Obata, Yasuko; Takayama, K.; Ngawhirunpat, Tanasait

doi:10.2147/ijn.s60674

Cited by 93 publications

(62 citation statements)

References 34 publications

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“…35 Four types of ultradeformable lipid vesicles, cationic-UDLs, UDLs, anionic-UDLs, and CLs, were prepared, according to the vesicle composition presented in Table 1.…”

Section: Preparation Of Imp-loaded Lipid Vesiclesmentioning

confidence: 99%

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Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery

Lin¹,

Xie²,

Huang³

et al. 2018

IJN

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Aim The aim of this work was to develop a novel vesicular carrier, ultradeformable liposomes (UDLs), to expand the applications of the Chinese herbal medicine, imperatorin (IMP), and increase its transdermal delivery. Methods In this study, we prepared IMP-loaded UDLs using the thin-film hydration method and evaluated their encapsulation efficiency, vesicle deformability, skin permeation, and the amounts accumulated in different depths of the skin in vitro. The influence of different charged surfactants on the properties of the UDLs was also investigated. Results The results showed that the UDLs containing cationic surfactants had high entrapment efficiency (60.32%±2.82%), an acceptable particle size (82.4±0.65 nm), high elasticity, and prolonged drug release. The penetration rate of IMP in cationic-UDLs was 3.45-fold greater than that of IMP suspension, which was the highest value among the vesicular carriers. UDLs modified with cationic surfactant also showed higher fluorescence intensity in deeper regions of the epidermis. Conclusion The results of our study suggest that cationic surfactant-modified UDLs could increase the transdermal flux, prolong the release of the drug, and serve as an effective dermal delivery system for IMP.

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“…35 Four types of ultradeformable lipid vesicles, cationic-UDLs, UDLs, anionic-UDLs, and CLs, were prepared, according to the vesicle composition presented in Table 1.…”

Section: Preparation Of Imp-loaded Lipid Vesiclesmentioning

confidence: 99%

“…In contrast, anionic surfactant-treated stratum corneum is relatively brittle, possibly because of extraction of a natural moisturizing factor. 35 However, lipid lamellae of the stratum corneum contain a high proportion …”

Section: In Vitro Skin Permeation Of Lipid Vesiclesmentioning

confidence: 99%

Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery

Lin¹,

Xie²,

Huang³

et al. 2018

IJN

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show abstract

“…The surfactant properties (i.e., charge, carbon chain length and content of surfactant) are known to directly affect the skin permeability of meloxicam when formulated as deformable liposomes (Duangjit et al, 2014). Alomrani et al (2014) proved the effect of the edge activators and hydroxypropyl-beta-cyclodextrine on the skin disposition of itraconazole.…”

Section: The Effect Of Carrier/vehicle On the Skin Penetrationmentioning

confidence: 99%

In vitro skin models as a tool in optimization of drug formulation

Flaten

Palac²,

Engesland

et al. 2015

European Journal of Pharmaceutical Sciences

182

135

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Abstract(Trans)dermal drug therapy is gaining increasing importance in the modern drug development. To fully utilize the potential of this route, it is important to optimize the delivery of active ingredient/drug into/through the skin. The optimal carrier/vehicle can enhance the desired outcome of the therapy therefore the optimization of skin formulations is often included in the early stages of the product development. A rational approach in designing and optimizing skin formulations requires well-defined skin models, able to identify and evaluate the intrinsic properties of the formulation. Most of the current optimization relies on the use of suitable ex vivo animal/human models.However, increasing restrictions in use and handling of animals and human skin stimulated the search for suitable artificial skin models. This review attempts to provide an unbiased overview of the most commonly used models, with emphasis on their limitations and advantages. The choice of the most applicable in vitro model for the particular purpose should be based on the interplay between the availability, easiness of the use, cost and the respective limitations.

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“…This, in turn, is directly proportional to the high transition temperature (Tc) of DSPC (Tc=55°C) (29,30). The increase in the drug release in the presence of SLS is due to the partial destabilization of RMNLs (31). Additionally, the high stability of the prepared liposomes by DSPC is suitable for in vivo application.…”

Section: Discussionmentioning

confidence: 99%