Role of the combination of FA and  parameters as a new diagnostic method in therapeutic evaluation of parkinson's disease

Fang, Yuan; Zheng, Tao; Liu, Lanxiang; Gao, Dawei; Shi, Qinglei; Dong, Yanchao; Du, Dan

doi:10.1002/jmri.25900

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…A decrease in T2 * relaxation time in the substantia nigra of PD patients compared to healthy controls was reported by Egger et al (2018) however, this decrease did not reach statistical significance. Decrease in T2 * relaxation time was also reported in two studies of experimental Parkinsonism in a rat model of nigro-striatal denervation (Soria et al, 2011;Fang et al, 2018). Increased iron, copper and manganese concentrations in the substantia nigra were reported in a mouse model of experimental Parkinsonism (Matusch et al, 2012).…”

Section: Discussionmentioning

confidence: 67%

Cerebral Microstructural Alterations in Patients With Early Parkinson’s Disease Detected With Quantitative Magnetic Resonance Measurements

Klietz

Elaman

Mahmoudi

et al. 2021

Front. Aging Neurosci.

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Objective: Parkinson’s disease (PD) is the second most common neurodegenerative disease in the elderly. In early stages of PD, patients typically display normal brain magnet resonance imaging (MRI) in routine screening. Advanced imaging approaches are necessary to discriminate early PD patients from healthy controls. In this study, microstructural changes in relevant brain regions of early PD patients were investigated by using quantitative MRI methods.Methods: Cerebral MRI at 3T was performed on 20 PD patients in early stages and 20 age and sex matched healthy controls. Brain relative proton density, T1, T2, and T2′ relaxation times were measured in 14 regions of interest (ROIs) in each hemisphere and compared between patients and controls to estimate PD related alterations.Results: In comparison to matched healthy controls, the PD patients revealed decreased relative proton density in contralateral prefrontal subcortical area, upper and lower pons, in ipsilateral globus pallidus, and bilaterally in splenium corporis callosi, caudate nucleus, putamen, thalamus, and mesencephalon. The T1 relaxation time was increased in contralateral prefrontal subcortical area and centrum semiovale, putamen, nucleus caudatus and mesencephalon, whereas T2 relaxation time was elevated in upper pons bilaterally and in centrum semiovale ipsilaterally. T2′ relaxation time did not show significant changes.Conclusion: Early Parkinson’s disease is associated with a distinct profile of brain microstructural changes which may relate to clinical symptoms. The quantitative MR method used in this study may be useful in early diagnosis of Parkinson’s disease. Limitations of this study include a small sample size and manual selection of the ROIs. Atlas-based or statistical mapping methods would be an alternative for an objective evaluation. More studies are necessary to validate the measurement methods for clinical use in diagnostics of early Parkinson’s disease.

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Section: Discussionmentioning

confidence: 67%

Cerebral Microstructural Alterations in Patients With Early Parkinson’s Disease Detected With Quantitative Magnetic Resonance Measurements

Klietz

Elaman

Mahmoudi

et al. 2021

Front. Aging Neurosci.

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“…3b). Using models of both 6-OHDA and rotenone, Liu et al reported an immediate FA decrease in the SN, followed by an increase six weeks after the injection in comparison with the sham controls (Liu et al, 2018a), while a persistent decrease after one and six weeks was also reported (Fang et al, 2018). This decrease in FA was also observed in the MitoPark animals (Cong et al, 2016).…”

Section: Neurodegenerative Diseasesmentioning

confidence: 86%

Diffusion-weighted MRI in neurodegenerative and psychiatric animal models: Experimental strategies and main outcomes

Eed

Cerdá

Lerma

et al. 2020

Journal of Neuroscience Methods

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Preclinical MRI approaches constitute a key tool to study a wide variety of neurological and psychiatric illnesses, allowing a more direct investigation of the disorder substrate and, at the same time, the possibility of backtranslating such findings to human subjects. However, the lack of consensus on the optimal experimental scheme used to acquire the data has led to relatively high heterogeneity in the choice of protocols, which can potentially impact the comparison between results obtained by different groups, even using the same animal model. This is especially true for diffusion-weighted MRI data, where certain experimental choices can impact not only on the accuracy and precision of the extracted biomarkers, but also on their biological meaning. With this in mind, we extensively examined preclinical imaging studies that used diffusion-weighted MRI to investigate neurodegenerative, neurodevelopmental and psychiatric disorders in rodent models. In this review, we discuss the main findings for each preclinical model, with a special focus on the analysis and comparison of the different acquisition strategies used across studies and their impact on the heterogeneity of the findings.

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“…Here, in a first step, levodopa-induced dyskinesia in MPTP/MDMA-intoxicated monkeys, as a model of the “classical” treatment complication in humans, were assessed by PET imaging and MRI including DTI, and severity of levodopa-induced dyskinesia was correlated to MD decreases in the ventral striatum but were no more altered after lesion of serotonergic fibers and the second levodopa period, highlighting that DTI is complementary to PET to decipher pathophysiological mechanisms underlying treatment-associated complications (Beaudoin-Gobert et al, 2018 ). As an example, for the use in therapy monitoring in a prospective case–control animal study in rats with the 6-OHDA model, simple diffusion delivery (direct microinjection of the drug into the brain tissue) of rasagiline was assessed by DTI and T2 * mapping (Fang et al, 2018 ). The authors could show that FA values of the substantia nigra in the simple diffusion delivery treatment group were significantly higher at week 1 and lower at week 6 than that of the PD control group; given that higher T2 * parameters at week 6 showed the same pattern, the authors considered the combination to be more reliable than other traditional methods for evaluating the curative effect of PD drugs in animal models.…”

Section: Applications To Models Of Neurodegenerative Diseasesmentioning

confidence: 99%

Diffusion Tensor Imaging-Based Studies at the Group-Level Applied to Animal Models of Neurodegenerative Diseases

et al. 2020

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The understanding of human and non-human microstructural brain alterations in the course of neurodegenerative diseases has substantially improved by the non-invasive magnetic resonance imaging (MRI) technique of diffusion tensor imaging (DTI). Animal models (including disease or knockout models) allow for a variety of experimental manipulations, which are not applicable to humans. Thus, the DTI approach provides a promising tool for cross-species cross-sectional and longitudinal investigations of the neurobiological targets and mechanisms of neurodegeneration. This overview with a systematic review focuses on the principles of DTI analysis as used in studies at the group level in living preclinical models of neurodegeneration. The translational aspect from in-vivo animal models toward (clinical) applications in humans is covered as well as the DTI-based research of the non-human brains' microstructure, the methodological aspects in data processing and analysis, and data interpretation at different abstraction levels. The aim of integrating DTI in multiparametric or multimodal imaging protocols will allow the interrogation of DTI data in terms of directional flow of information and may identify the microstructural underpinnings of neurodegeneration-related patterns.

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Role of the combination of FA and parameters as a new diagnostic method in therapeutic evaluation of parkinson's disease

Abstract: 1 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2017.

Cited by 5 publications

References 30 publications

Cerebral Microstructural Alterations in Patients With Early Parkinson’s Disease Detected With Quantitative Magnetic Resonance Measurements

Cerebral Microstructural Alterations in Patients With Early Parkinson’s Disease Detected With Quantitative Magnetic Resonance Measurements

Diffusion-weighted MRI in neurodegenerative and psychiatric animal models: Experimental strategies and main outcomes

Diffusion Tensor Imaging-Based Studies at the Group-Level Applied to Animal Models of Neurodegenerative Diseases

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