Role of the corpus callosum in the somatosensory activation of the ipsilateral cerebral cortex: an fMRI study of callosotomized patients

Fabri, Mara; Polonara, Gabriele; Quattrini, Angelo; Salvolini, U.; Pesce, M. Del; Manzoni, T

doi:10.1046/j.1460-9568.1999.00829.x

Cited by 79 publications

(59 citation statements)

References 86 publications

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“…1). Two of these patients (DDV, RN) had participated in a previous study (Fabri et al, 1999a). The clinical history and extent of callosal resection of all patients have been reported previously Quattrini et al, 1989Quattrini et al, , 1994Fabri et al, 1999a).…”

Section: Methodsmentioning

confidence: 84%

Mechanical Noxious Stimuli Cause Bilateral Activation of Parietal Operculum in Callosotomized Subjects

Fabri

Polonara²,

Quattrini³

et al. 2002

Cerebral Cortex

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The patterns of cortical activation evoked by tactile and mechanical painful stimulation in six normal subjects and three patients with complete resection of the corpus callosum are described and compared, with emphasis on the parietal operculum. Stimulusrelated cortical activation was investigated by functional magnetic resonance imaging. In both groups, painful stimulation activated the first somatosensory, insular and cingulate cortices in the contralateral hemisphere, and the parietal opercular cortex in both hemispheres. Comparison between the two patterns of cortical activation demonstrated that ipsilateral activation by unilateral painful stimulation is at least partially independent of the corpus callosum and suggests a different organization of the pain and touch systems.

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Section: Methodsmentioning

confidence: 84%

Mechanical Noxious Stimuli Cause Bilateral Activation of Parietal Operculum in Callosotomized Subjects

Fabri

Polonara²,

Quattrini³

et al. 2002

Cerebral Cortex

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“…59,60 The sensory cortical representations are interhemispherically linked to their homotopic counterparts in the opposite hemisphere via fibers that traverse the corpus callosum. [61][62][63] This pathway is usually inhibited under normal circumstances but could be disinhibited in the presence of a unilateral stroke. 64 A previous study indicated that inhibition of the transcallosal pathway is reduced in the event of a unilateral focal stroke.…”

Section: Bilateral Forepaw Stimulation Results In Better Outcome Thanmentioning

confidence: 99%

Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model

et al. 2014

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Abstract. Restoring perfusion to the penumbra during the hyperacute phase of ischemic stroke is a key goal of neuroprotection. Thrombolysis is currently the only approved treatment for ischemic stroke. However, its use is limited by the narrow therapeutic window and side effect of bleeding. Therefore, other interventions are desired that could potentially increase the perfusion of the penumbra. Here, we hypothesized that bilateral peripheral electrical stimulation will improve cerebral perfusion and restore cortical neurovascular response. We assess the outcomes of bilateral forepaw electrical stimulation at intensities of 2 and 4 mA, administered either unilaterally or bilaterally. We developed a combined electrocorticogram (ECoG)-functional photoacoustic microscopy (fPAM) system to evaluate the relative changes in cerebral hemodynamic function and electrophysiologic response to acute, focal stroke. The fPAM system is used for cerebral blood volume (CBV) and hemoglobin oxygen saturation (SO 2 ) and the ECoG for neural activity, namely somatosensory-evoked potential (SSEP), interhemispheric coherence, and alpha-delta ratio (ADR) in response to forepaw stimulation. Our results confirmed the neuroprotective effect of bilateral forepaw stimulation at 2 mA as indicated by the 82% recovery of ADR and 95% improvement in perfusion into the region of penumbra. This experimental model can be used to study other potential interventions such as therapeutic hypertension and hypercarbia.

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“…The lesser recruitment of these areas over time suggests that recourse to such strategies becomes less necessary with time, in parallel with motor recovery. In normal subjects, the bilateral activation of BA 40 has been related to transcallosal connections, 33 which may therefore be involved during motor recovery.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Motor Network Overactivation After Striatocapsular Stroke: A Longitudinal PET Study Using a Fixed-Performance Paradigm

Calautti¹,

Leroy²,

Guincestre³

et al. 2001

Stroke

243

189

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Background and Purpose-Although excessive brain activation during affected hand motion after stroke is well documented, its time course has been rarely studied, and when studied, this has either been with passive movement or with active but cognitively complex task and uncontrolled performance over time, complicating interpretation. Methods-According to a prospective and longitudinal design, we studied 5 right-handed patients with right-sided hemiparesis due to first-ever left striatocapsular infarction. Three-dimensional PET H 2 O 15 studies were performed twice (Ϸ7 and Ϸ31 weeks after stroke [PET1 and PET2, respectively]) during right thumb-to-index tapping executed at the same rate in both studies (1.26 Hz, auditory cued). With SPM96 software, significant group and individual overactivations (PϽ0.05, corrected for multiple comparisons) were computed by comparison with a group of 7 healthy age-matched right-handed control subjects performing the same task. Results-Motor recovery was significant from PET1 to PET2. Both the group and individual analyses revealed striking overactivations at PET1, affecting notably the cortical hand area and the whole motor network bilaterally. These overactivations were less prominent at PET2 over both hemispheres, not only in terms of Z score but also in terms of spatial extent (almost reaching statistical significance in the affected hemisphere for the latter, Pϭ0.09). However, new overactivations were found at PET2 in the left prefrontal areas, the putamen, and the premotor cortex. Conclusions-This study is the first to document that to perform the same simple movement of the paretic fingers, the brain with subcortical infarction shows less overactivations at the late than at the early timepoint, especially on the affected side, suggesting reduced recruitment of affected-hemisphere motor networks. However, unaffected-hemisphere prefrontal, premotor, and putaminal overactivations, observed at PET2 only, may suggest late-appearing compensatory reorganization. (Stroke. 2001;32:2534-2542.)

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Role of the corpus callosum in the somatosensory activation of the ipsilateral cerebral cortex: an fMRI study of callosotomized patients

Cited by 79 publications

References 86 publications

Mechanical Noxious Stimuli Cause Bilateral Activation of Parietal Operculum in Callosotomized Subjects

Mechanical Noxious Stimuli Cause Bilateral Activation of Parietal Operculum in Callosotomized Subjects

Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model

Dynamics of Motor Network Overactivation After Striatocapsular Stroke: A Longitudinal PET Study Using a Fixed-Performance Paradigm

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