2010
DOI: 10.1016/j.toxlet.2010.10.003
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Role of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticles

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Cited by 575 publications
(399 citation statements)
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“…Thus, the almost generic oxidative stress that has been observed with zinc oxide 5,14 , can be attributed to a more general perturbation leading to an imbalance in cellular redox cycles and thus to ROS production.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, the almost generic oxidative stress that has been observed with zinc oxide 5,14 , can be attributed to a more general perturbation leading to an imbalance in cellular redox cycles and thus to ROS production.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies described different methods to prepare NP suspension, either directly in the medium by simple agitation (Yang et al 2009;Yuan et al 2010), by using bath sonication (Huang et al 2010;Pujalté et al 2011;Song et al 2010;Xiong et al 2011) or stabilisers such as bovine serum albumin (Tantra et al 2010;Yang et al 2009) to eliminate possible aggregates. However, it was recently recommended to not discard these aggregates since their implication in the toxicity of ZnO NPs in embryo and adult zebrafish (Bai et al 2010;Xiong et al 2011) and human cells (Yuan et al 2010) was demonstrated.…”
Section: Discussionmentioning
confidence: 99%
“…ZnO NPs have been shown to produce in vitro cytotoxic, genotoxic, inflammatory and oxidative stress responses in different mammalian cells (Xia et al 2008;Yang et al 2009;Huang et al 2010;Song et al 2010;De Berardis et al 2010;Yuan et al 2010;Hsiao & Huang 2011;Pujalté et al 2011). Studies in mammalian cell lines also attributed the toxicity of ZnO NPs, at least in part, to their solubility, the latter leading to Zn ion formations (Xia et al 2008;De Berardis et al 2010;Song et al 2010).…”
Section: Introductionmentioning
confidence: 99%
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“…Quando em excesso ele parece estar associado com uma exacerbação da resposta inflamatória (SONG et al, 2010;TSOU et al, 2010), redução da absorção do Cu, declive no teor sérico de HDL (BARCELOUX, 1999) e disfunção da função renal e hepática (MIRAZI et al, 2012). …”
Section: Zinco (Zn)unclassified