Role of the endoplasmic reticulum in mechanisms of aging and formation of senescent cells

Salnikov, Lev

doi:10.1016/j.tma.2024.07.001

Translational Medicine of Aging

2024

DOI: 10.1016/j.tma.2024.07.001

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Role of the endoplasmic reticulum in mechanisms of aging and formation of senescent cells

Lev Salnikov

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2024

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Aging mechanisms and their relationship with the ontogenesis program: a narrative review

Salnikov

2024

Aging Advances

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The main challenge in understanding the mechanisms and causes of aging is that separating the consequences of aging from its causes is very difficult. This review presents our perspective on the underlying mechanisms of aging and their relationship with the process of ontogenesis. The present data show the discrimination of RNA production for the part of the genome responsible for the cellular infrastructure, which begins after fertility is reached. This discrimination is also present at the level of translation, as shown by evidence for age-related changes in the distribution between membrane-bound and free ribosomes in cells, where their number decreases with age. This review also provides an assessment of the useful information of hallmarks of aging in terms of their importance in understanding the mechanisms of aging. A direction for rejuvenation is presented, which follows from our understanding of aging mechanisms and leads to the idea of cellular autocloning, which is designed to stop aging. The principle of the proposed method is to initiate a periodic process of autocloning in the cell nucleus. In the process of such division, two daughter nuclei are formed, one of which is self-liquidated, leaving in the cell its renewed nucleus without physical division of the cell itself. This process, when started periodically, allows aging to be nullified or stopped at the “cellular age” when the process is initiated.

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Aging mechanisms and their relationship with the ontogenesis program: a narrative review

Salnikov

2024

Aging Advances

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Role of the endoplasmic reticulum in mechanisms of aging and formation of senescent cells

Cited by 1 publication

References 33 publications

Aging mechanisms and their relationship with the ontogenesis program: a narrative review

Aging mechanisms and their relationship with the ontogenesis program: a narrative review

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