Role of the Gut Microbiota in Age-Related Chronic Inflammation

Rehman, Tayyab

doi:10.2174/187153012803832620

Cited by 64 publications

(41 citation statements)

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“…392 393 Our work has implications for future studies examining the relationship of the gut microbiome 394 and the immune system in the context of age. Diversification of the gut microbiome in 395 association with age may contribute to age-related inflammation through mediation of nutrient 396 metabolism and immunity (Rehman, 2012;Magrone & Jirillo, 2013). This may include 397 differences in bacterial metabolites, and production of inflammatory mediators influencing local 398 and systemic processes such as gut permeability and immune function.…”

Section: Introduction 84mentioning

confidence: 99%

Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

Conley

Wong

Duyck

et al. 2016

Preprint

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Introduction Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of immunosenescence. Immunosenescence may play an important role in the development of age-related chronic disease and the widely observed phenomenon of increased production of inflammatory mediators that accompany this process, referred to as “inflammaging”. While it has been demonstrated that the gut microbiome and immune system interact, the relationship between the gut microbiome and age remains to be clearly defined, particularly in the context of inflammation. The aim of the study was to clarify the associations between age, the gut microbiome, and pro-inflammatory marker serum MCP-1 in a C57BL/6 murine model. Results We used 16S rRNA gene sequencing to profile the composition of fecal microbiota associated with young and aged mice. Our analysis identified an association between microbiome structure and mouse age, and revealed specific groups of taxa whose abundances stratify young and aged mice. This includes the Ruminococcaceae, Clostridiaceae, and Enterobacteriaceae. We also profiled pro-inflammatory serum MCP-1 levels of each mouse and found that aged mice exhibited elevated serum MCP-1, a phenotype consistent with inflammaging. Robust correlation tests identified several taxa whose abundance in the microbiome associates with serum MCP-1 status, indicating that they may interact with the mouse immune system. We find that taxonomically similar organisms can exhibit differing, even opposite, patterns of association with the host immune system. We also find that many of the OTUs that associate with serum MCP-1 also stratify individuals by age. Discussion Our results demonstrate that gut microbiome composition is associated with age and the pro-inflammatory marker, serum MCP-1. The correlation between age, relative abundance of specific taxa in the gut microbiome, and serum MCP-1 status in mice indicates that the gut microbiome may play a modulating role in age-related inflammatory processes. These findings warrant further investigation of taxa associated with the inflammaging phenotype and the role of gut microbiome in the health status and immune function of aged individuals.

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Section: Introduction 84mentioning

confidence: 99%

Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

Conley

Wong

Duyck

et al. 2016

Preprint

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“…Relationship between the impaired gastrointestinal tract, imbalanced gut microbiota, and chronic inflammation is significantly associated with increased disease risk in elderly populations, such as infections, inflammatory bowel disease (IBD) and colorectal cancer (CRC). Adapted from [154].…”

Section: Age-related Changes and Diseasementioning

confidence: 99%

Impact of high fat diets, prebiotics and probiotics on gut microbiota and immune function, with relevance to elderly populations

Liu¹,

Gibson²,

Walton

2016

NUA

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Abstract. According to WHO, the number of people over 60 years of age is set to rise to 2 billion by 2050. Dysbiosis of microbial composition and impaired immune function have been observed in elderly persons compared to younger adults. As a result, the aging population has a higher disease risk than other age groups. In addition, high fat intakes have been observed to exert negative effects on microbial composition and immune function in murine studies. Elderly people have higher fat intakes than recommended levels, and this may make them more vulnerable to disease risk. Therefore, the impact of high fat consumption on elderly populations may be of relevance. Prebiotics and probiotics have been shown to have positive effects on microbiota composition and immune function in the elderly. This review describes aged-related changes in gut microbiome of elderly persons. It will also summarise studies concerning the impact of prebiotics, probiotics and high fat diets on microbiota composition and immune function.

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“…Inadequate sanitation, hygiene, and untidy environmental conditions are the probable reason suggested for it. [1] Parasitic nematodes affect considerably all age groups, causing ill health and poor growth with a number of diseases like helmintic infections of gastro intestinal tract (resulting in dyspepsia, constipation, and other conditions) and malaria. Malaria is now a major health problem, especially in sub-tropical and tropical countries.…”

Section: Introductionmentioning

confidence: 99%

Experimental studies on bioactive potential of rutin

Dubey¹,

Ganeshpurkar²,

Bansal³

et al. 2013

Chron Young Sci

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Background: Plant-derived phytochemicals are gaining wide popularity owing to their diverse therapeutic potential and less side effects. Rutin is one of the plant-derived flavonoid. Rutin has demonstrated cardio protective, analgesic, and anticancer effects. Aim: The current work was focused to evaluate bioactive potential of rutin. Materials and Methods: Rutin was isolated from tobacco leaves. The structure was confirmed by H 1 NMR spectroscopy. The isolated rutin was studied for possible antibacterial, antifungal, anthelmintic, larvicidal, and cytotoxic effects. Results: Results of studies demonstrated that rutin effectively inhibited growth of bacteria and fungi, as well as demonstrated anthelmintic potential. There was a positive response for larvicidal and cytotoxic effects. Conclusion: These studies justify chemotherapeutic potential of rutin.

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Role of the Gut Microbiota in Age-Related Chronic Inflammation

Cited by 64 publications

References 0 publications

Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

Aging and serum MCP-1 are associated with gut microbiome composition in a murine model

Impact of high fat diets, prebiotics and probiotics on gut microbiota and immune function, with relevance to elderly populations

Experimental studies on bioactive potential of rutin

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