Abstract:Heparin-binding eGF-like growth factor (HB-eGF) is a member of the epidermal growth factor family that was proven as a potent mitogen and chemoattractant. HB-eGF mediated eGFr activation is a key event in the stimulation of gene expression, cell migration and proliferation during both normal and pathogenic physiological processes. The main goal of this research was to reveal the role of the heparin-binding domain of HB-eGF in the ligand-receptor formation and its further internalization to the cytoplasm. We us… Show more
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