Role of the impulse oscillometry in the evaluation of tracheal stenosis

Linhas, Rita; Lima, Fátima; Coutinho, Daniel; Almeida, José; Neves, Sofia; Oliveira, Ana; Ladeira, Inês; Lima, Ricardo; Campainha, Sérgio; Guimarães, Miguel

doi:10.1016/j.pulmoe.2017.12.006

Cited by 6 publications

(5 citation statements)

References 29 publications

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“…Anatomical stenosis severity was found to be significantly correlated with both dyspnea and several spirometric indices, with the highest correlation coefficients for PEF, FEV1/PEF, and the MRC dyspnea score. Previous studies in benign laryngotracheal stenosis have also correlated grade of stenosis with the MRC score, PEF, and FEV1/PEF; however, with variable and contradicting results [8,25,27,28].…”

Section: Discussionmentioning

confidence: 97%

“…Exertional dyspnea and stridor are hallmark symptoms of laryngotracheal stenosis [3,26]. The MRC dyspnea scale has been confirmed as an appropriate outcome measure to assess treatment efficacy in benign laryngotracheal stenosis [24,25]. In a recent study on idiopathic subglottic stenosis, the MRC scale and quality of life were closely correlated with PEF% and disease severity [17].…”

Section: Discussionmentioning

confidence: 98%

“…Routine follow-up after initial management is necessary in benign tracheal stenosis, to detect relapse. Bronchoscopy, although considered the gold standard, is an invasive procedure with inherent risks [5,9,24,25]. Therefore, it is important to also have a noninvasive, validated test, to avoid unnecessary bronchoscopies.…”

Section: Discussionmentioning

confidence: 99%

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The Value of Dyspnea and Spirometry in Detecting Relapse of Benign Tracheal Stenosis

et al. 2021

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Background: Benign tracheal stenosis may relapse after management. Objectives: This study aimed to assess the value of dyspnea and spirometry in detecting relapse of benign tracheal stenosis. Methods: Patients with benign tracheal stenosis were evaluated post-management, at regular follow-up and emergency visits, with the Medical Research Council (MRC) dyspnea scale, spirometry, and flexible bronchoscopy. Patient visits were categorized and compared, in terms of change in clinical and functional parameters, in 2 groups: visits with relapse (case group) and visits with no relapse (control group). The ability of the MRC dyspnea scale and spirometry to predict relapse was evaluated. Results: Thirty-five patients with benign tracheal stenosis were included. Mean follow-up duration was 3.2 years (standard deviation = 3.3). Spirometry data were analyzed from 43 relapse visits (23 patients) versus 90 nonrelapse visits. The MRC dyspnea score and most spirometric indices were associated with relapse. In the receiver operating characteristic analysis, forced expiratory volume in 1 s, forced expiratory flow when 25% of forced vital capacity has been expired, peak expiratory flow (PEF), and total peak flow were superior to the MRC dyspnea score in predicting relapse. Among spirometric indices, >10.8% of PEF reduction has been very sensitive and specific. Conclusions: This study supports the role of dyspnea and spirometry in monitoring benign tracheal stenosis, with spirometry predicting relapse even in clinically stable patients. PEF being a very sensitive index has the additional advantage of being assessed by peak flow meter and could potentially be used for remote monitoring.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

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The Value of Dyspnea and Spirometry in Detecting Relapse of Benign Tracheal Stenosis

et al. 2021

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“…IOS has been used for the diagnosis and monitoring of respiratory tract diseases such as asthma, virus-induced wheezing, 11 bronchopulmonary dysplasia, 31 cystic fibrosis, 32 eosinophilic bronchitis, 33 bronchiectasis, 34 vocal cord dysfunction, 35 and tracheal stenosis, 36 etc., and to assess bronchial hyperresponsiveness 37 and the response to asthma treatment. 38 , 39…”

Section: Available Data For Diagnosing and Following Asthma In Childr...mentioning

confidence: 99%

Utility of biomarkers in the diagnosis and monitoring of asthmatic children

Xepapadaki

Adachi

Beltrán

et al. 2023

World Allergy Organization Journal

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“…Computational fluid dynamic (CFD) modeling can provide detailed flow-pressure responses and is promising to improve our understanding of the interactions among different reactive constituents in human lungs. The IOS systems were developed based on the LRC concept and linear assumptions [53]. Note that the airflows in the large airway are not laminar, and the relationship between the pressure and flow is not linear [54].…”

Section: Cfd As a Complementary Tool In Understanding Ios Responsesmentioning

confidence: 99%

Evaluation of Impulse Oscillometry in Respiratory Airway Casts with Varying Obstruction Phenotypes, Locations, and Complexities

Talaat

et al. 2022

JoR

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The use of impulse oscillometry (IOS) for lung function testing does not need patient cooperation and has gained increasing popularity among both young and senior populations, as well as in patients with breathing difficulties. However, studies of the IOS sensitivity to regional lung obstructions are limited and have shown mixed results. The objective of this study was to evaluate the performance of an IOS system in 3D-printed lung models with structural abnormalities at different locations and with different severities. Lung trees of two complexity levels were tested, with one extending to the sixth generation (G6) and the other to G12. The IOS responses to varying glottal apertures, carina ridge tumors, and segmental bronchial constrictions were quantified in the G6 lung geometry. Both the G6 and G12 lung casts were prepared using high-resolution 3D printers. Overall, IOS detected the progressive airway obstructions considered in this study. The resonant frequency dropped with increasing obstructions for all three disease phenotypes in the G6 lung models. R20Hz increased with the increase in airway obstructions. Specifically, R20Hz in the airway model with varying glottal apertures agreed reasonably well with complementary measurements using TSI VelociCalc. In contrast to the high-resistance (R) sensitivity to the frequency in G6 lung models, R was nearly independent of frequency in G12 lung models. IOS R20Hz demonstrated adequate sensitivity to the structural remodeling in the central airways. However, the changes of R5Hz and X5Hz vs. airway obstructions were inconclusive in this study, possibly due to the rigid lung casts and the difference of a container–syringe system from human lungs.

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Role of the impulse oscillometry in the evaluation of tracheal stenosis

Cited by 6 publications

References 29 publications

The Value of Dyspnea and Spirometry in Detecting Relapse of Benign Tracheal Stenosis

The Value of Dyspnea and Spirometry in Detecting Relapse of Benign Tracheal Stenosis

Utility of biomarkers in the diagnosis and monitoring of asthmatic children

Evaluation of Impulse Oscillometry in Respiratory Airway Casts with Varying Obstruction Phenotypes, Locations, and Complexities

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