Role of the Intestinal Immune System in Health

Brandtzæg, Per

doi:10.1007/978-3-319-33703-6_2

Cited by 4 publications

(2 citation statements)

References 323 publications

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“…Cytokines play crucial roles in inflammation and immune response. When the body suffered from foreign microorganisms or toxic substances, the immune system will immediately secrete inflammatory factors such as IL-6, IL-10, TNF-α, and IFN-γ, thus promoting immune response and restoring immune homeostasis ( Brandtzaeg, 2017 ). Studies have shown that AMPs can enhance adaptive immunity by regulating proinflammatory and anti-inflammatory factors and inducing chemotactic activity ( Wang et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Compound bioengineering protein supplementation improves intestinal health and growth performance of broilers

Tang,

Yin,

Peng

et al. 2023

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Compound bioengineering protein supplementation improves intestinal health and growth performance of broilers

Tang,

Yin,

Peng

et al. 2023

Poultry Science

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“…3). IL-6 and TNF-α were important mediator of in ammatory response, which were commonly used as markers for systemic pro-in ammatory cytokine activation [37], and TNF-a, IL-1β…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary licorice extract on serum Biochemical index, tissues antioxidant capacity and immunity function of weaned piglets

You¹,

Yong²,

Jia³

et al. 2020

Preprint

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Background: This study investigated the effects of dietary licorice extract (LE) on antioxidant capacity and immunity in weaned piglets. A total of 96 DLY (Duroc × Landrace × Yorkshire) weaned piglets were randomly assigned to four treatments. The control group were fed a corn–soybean meal-based diet (basal diet, BD), and three LE level groups were fed on BD supplied with 50、150 and 250 mg/kg LE. The trial lasted 5 weeks. At day 35, six piglets per treatment were killed and blood, liver, spleen, and thymus were collected.Results: The result showed that: 1)Dietary LE increased (P < 0.05) activity of the alkaline phosphatase (ALP) and reduced (P < 0.05) the activity of glutamic oxalacetic transaminase (AST), 50 mg / kg LE reduced (P < 0.05) total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) in serum. 2) The addition of 150 and 250 mg / kg LE increased (P < 0.05) glutathion peroxidase (GSH-Px) activity in liver and spleen, increased (P < 0.05) the total antioxidant capacity (T-AOC) in serum and spleen . 50 mg / kg LE increased (P < 0.05) the total superoxide dismutase (T-SOD) activity in serum. Three doses of LE reduced (P < 0.05) serum malondialdehyde content (MDA). 3) 150 mg / kg LE increased (P < 0.05) serum IgG level. 4) Dietary LE down-regulated (P < 0.05) the mRNA levels of 7 immune-related genes (IL-6, IL-8, IL-10, IL-1β, TNF-α, MCP-1, ICAM-1) in the thymus; 50 mg / kg LE and 150 mg / kg LE down-regulated (P < 0.05) the mRNA levels of TNF-α, while 250 mg / kg LE up-regulated the mRNA levels of 2 inflammatory genes (IL-1β, and ICAM-1) in the spleen; three levels of LE down-regulated (P < 0.05 the mRNA levels of 3 inflammatory genes (IL-6, TNF-α, ICAM-1) in the liver.Conclusions: In summary, LE supplementation regulates the activity of serum biochemical enzyme, improves the antioxidant capacity and immune function of in serum, liver, spleen and thymus, those improvement may contributes to the promotion of growth performance of weaned piglets. In general, 150 mg / kg LE exhibits better effect.

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Longan pulp polysaccharide protects against cyclophosphamide-induced immunosuppression in mice by promoting intestinal secretory IgA synthesis

Bai¹,

Huang²,

Zhang³

et al. 2020

Food Funct.

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Role of the Intestinal Immune System in Health

Cited by 4 publications

References 323 publications

Compound bioengineering protein supplementation improves intestinal health and growth performance of broilers

Compound bioengineering protein supplementation improves intestinal health and growth performance of broilers

Effects of dietary licorice extract on serum Biochemical index, tissues antioxidant capacity and immunity function of weaned piglets

Longan pulp polysaccharide protects against cyclophosphamide-induced immunosuppression in mice by promoting intestinal secretory IgA synthesis

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