Role of the intraparietal sulcus (IPS) in anxiety and cognition: Opportunities for intervention for anxiety-related disorders

Brown, Lily A.; White, Lauren K.; Makhoul, Walid; Teferi, Marta; Sheline, Yvette; Balderston, Nicholas L.

doi:10.1016/j.ijchp.2023.100385

Cited by 5 publications

(2 citation statements)

References 73 publications

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“…For what concerns the gray matter circuits, previous research has pointed out the role of different parietal and frontal regions in anxiety disorders [31][32][33] , for their involvement in attentional, emotional and decision making functions.…”

Section: Discussionmentioning

confidence: 99%

Fronto-parietal and cerebellar circuits characterise individuals with high trait anxiety: a parallel ICA and Random Forest approach

Baggio,

Grecucci,

Crivello

et al. 2023

Preprint

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Anxiety is a diffuse condition that can range from mild to more severe manifestations, including proper anxiety disorders. Specific sensitive periods such as adolescence and young adulthood are particularly vulnerable to anxious states and may favour the onset of future anxiety disorders. Until now, neuroanatomical research on anxiety has focused mainly on adults, employed univariate inference-based approaches, and considered one single neuroimaging modality, thus leading to an incomplete picture. The aim of the present study is to characterize the joint GM-WM contribution in high versus low trait anxiety, in a large sample of young individuals, exploiting a data fusion machine learning technique known as Parallel ICA, and to build a predictive model of trait anxiety based on a Random Forest classifier. Additionally, we aimed to characterize high anxiety individuals for their usage of maladaptive coping strategies, and other affective dimensions such as anger, impulsivity, and stress, and to test their relevance in predicting new cases of high trait anxiety. At the neural level we found a fronto-parieto-cerebellar network to have a decrease gray matter concentration in high anxious individuals, and a parieto-temporal network to have an increase white matter concentration in high anxious individuals. Additionally, at the psychological level, individuals with high anxiety are characterized by higher stress, cognitive and motor impulsivity, and avoidance/emotional coping. Lastly, the Random Forest classifier robustly confirmed the goodness of the morphometric and psychological factors in predicting new cases of trait anxiety. As such, these findings may pave the road for the creation of an early biomarker of trait anxiety in young individuals, contributing to an early intervention to prevent the future development of anxiety disorders.

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Section: Discussionmentioning

confidence: 99%

Fronto-parietal and cerebellar circuits characterise individuals with high trait anxiety: a parallel ICA and Random Forest approach

Baggio,

Grecucci,

Crivello

et al. 2023

Preprint

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“…Finally, subjective affective ratings related positively to myeloarchitecture in the postcentral gyrus and intraparietal sulcus, in a region more dorsal to the effect we observed for interoceptive precision. This region of the somatosensory cortex has been shown to be involved in attentional regulation and anxious arousal (Brown et al, 2023), and it has been proposed that neuromodulation of the nearby intraparietal sulcus (IPS; e.g., using TMS) could be used to reduce attention to threat and anxious arousal in clinical samples. The IPS exhibits strong functional connectivity within the fronto-parietal attention network (Cole et al, 2014), as well as with subcortical regions such as the locus coeruleus, known to be involved in anxiety (Liebe et al, 2022).…”

Section: Microstructural Brain Underpinnings Of Respiroceptive Metaco...mentioning

confidence: 99%

Microstructural Brain Correlates of Inter-individual Differences in Respiratory Interoception

Nikolova,

Fischer Ehmsen,

Banellis

et al. 2024

Preprint

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Interoception, the perception and integration of physiological signals, is a fundamental aspect of self-awareness and homeostasis. While previous work has explored interoceptive processing in relation to the cardiac system, research in the respiratory domain, particularly in relation to brain structure and function, is limited. To address this gap, we utilised a Bayesian psychophysical model to quantify perceptual, metacognitive, and affective dimensions of respiratory interoception in a sample of 207 healthy participants. We also measured individual whole-brain microstructural indices of myelination, myeloarchitecture, and cortical iron using quantitative brain imaging. Voxel-based quantification analyses revealed distinct patterns of cortical microstructure in the insular, cingulate, and primary sensory cortices, which underpin interoceptive perceptual sensitivity and precision. In addition, metacognitive bias was associated with increased myelination of the cingulate cortex and periaqueductal grey, while metacognitive sensitivity correlated with myelination of the midline prefrontal cortex. At an affective level, sensitivity to respiratory resistance was related to the myelination of the primary somatosensory cortex. By revealing specific histological brain patterns tied to individual differences in respiratory interoception, our results uncover the neural pathways that govern perceptual, metacognitive, and emotional facets of interoceptive processing.

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Threat of shock increases distractor susceptibility during the short-term maintenance of visual information

Casalvera,

Goodwin,

Lynch

et al. 2024

Social Cognitive and Affective Neuroscience

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Elevated arousal in anxiety is thought to affect attention control. To test this, we designed a visual short-term memory (VSTM) task to examine distractor suppression during periods of threat and no-threat. We hypothesized that threat would impair performance when subjects had to filter out large numbers of distractors. The VSTM task required subjects to attend to one array of squares while ignoring a separate array. The number of target and distractor squares varied systematically, with high (4 squares) and low (2 squares) target and distractor conditions. This study comprised two separate experiments. Experiment 1 used startle responses and white noise as to directly measure threat-induced anxiety. Experiment 2 used BOLD to measure brain responses. For Experiment 1, subjects showed significantly larger startle responses during threat compared to safe period, supporting the validity of the threat manipulation. For Experiment 2, we found that accuracy was affected by threat, such that distractor load negatively impacted accuracy only in the threat condition. We also found threat related differences in parietal cortex activity. Overall, these findings suggest that threat affects distractor susceptibility, impairing filtering of distracting information. This effect is possibly mediated by hyperarousal of parietal cortex during threat.

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Role of the intraparietal sulcus (IPS) in anxiety and cognition: Opportunities for intervention for anxiety-related disorders

Cited by 5 publications

References 73 publications

Fronto-parietal and cerebellar circuits characterise individuals with high trait anxiety: a parallel ICA and Random Forest approach

Fronto-parietal and cerebellar circuits characterise individuals with high trait anxiety: a parallel ICA and Random Forest approach

Microstructural Brain Correlates of Inter-individual Differences in Respiratory Interoception

Threat of shock increases distractor susceptibility during the short-term maintenance of visual information

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