Role of the kidney in regulating plasma immunoreactive beta-melanocyte-stimulating hormone.

Smith, A G; Shuster, Sam; Thody, A. J.; Álvarez-Ude, F; Kerr, D. N. S.

doi:10.1136/bmj.1.6014.874

Cited by 46 publications

(20 citation statements)

References 5 publications

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“…This theory is supported by the fact that anephric RDT patients have higher val ues of (3-.V1SH than those with their kidneys left [18]. Moreover, the kidney is known to extract several different peptides from the circulation [19,20].…”

Section: Impaired Renal Peptide Eliminationsupporting

confidence: 58%

Elevated Plasma Levels of Opioid Peptides and Delta Sleep-Inducing Peptide but Not of Corticotropin-Releasing Hormone in Patients Receiving Chronic Hemodialysis

1991

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The fasting plasma levels of corticotropin-releasing hormone (CRH), delta sleep-inducing peptide (DSIP), β-endorphin (β-END), methionine-enkephalin (m-ENK), β-lipotropin (β-LPH), and α-melanocyte-stimulating hormone (α-MSH) were measured by radioimmunoassay in 22 stable patients with chronic renal failure on regular hemodialysis treatment and compared with those of 10 healthy controls. The plasma concentrations of DSIP, β-END, m-ENK, β-LPH, and α-MSH were increased. The plasma level of CRH was not different from that of the controls. The elevated plasma levels of endogenous opioid peptides and DSIP may contribute to the uremic syndrome, although this must be further elucidated.

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Section: Impaired Renal Peptide Eliminationsupporting

confidence: 58%

Elevated Plasma Levels of Opioid Peptides and Delta Sleep-Inducing Peptide but Not of Corticotropin-Releasing Hormone in Patients Receiving Chronic Hemodialysis

1991

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“…Other reported hair abnormalities of trichoclasia and Trichorrhexis nodosa by Claudio Ponticelli et al 10 were not seen in our study.…”

Section: Hair Abnormalitiescontrasting

confidence: 53%

“…Diffuse hyperpigmentation on sun-exposed areas is attributed to an increase in melanin in the basal layer and superficial dermis due to failure of the kidneys to excrete beta-melanocyte stimulating hormone (β-MSH). 7,8,9,10 Perforating Dermatoses encountered in 3 patients clinically. Skin biopsy was done repeatedly for HPE.…”

Section: Specific Cutaneous Lesions Of Ckdmentioning

confidence: 99%

A Clinical Study of Cutaneous Manifestations of Chronic Kidney Disease

Aruna¹,

P²,

A³

et al. 2016

jemds

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BACKGROUNDThe kidneys and the skin are two important organs whose blood supply far exceeds their demand, the former for maintaining the milieu interior and the latter for rendering man homoeothermic. Changes of the skin are frequently seen in patients with kidney disease and in those who are undergoing dialysis. A number of diseases are characterised by distinctive cutaneous and renal manifestations. MATERIALS AND METHODSThis study spanned a course of 6 months from January 2011 to June 2011. During this period 82 patients admitted in the Nephrology ward of Osmania General Hospital for dialysis as well as those patients referred to the Dermatology Outpatient Department from the Nephrology Department were screened for evidence of cutaneous manifestations of kidney disease. Of these, 50 patients who had the presence of skin manifestations were selected and studied, both sexes and all age groups were included in the study. RESULTSOut of 50 patients in the age group of 1-70 years, (66%) maximum number of patients were observed between 3rd to 5th decade while least number in 1st and 2nd decade. Youngest Patient studied -Male, 7 Years. Oldest patient studied -Male, 69 Years. Xerosis or dryness of the skin was seen in 28 patients. 14 patients out 50 showed pallor. Pruritus was seen in 12 patients. Purpura was seen in 3 patients. Perforating dermatoses was seen in 3 patients. Fungal infections were seen in 9 patients. Bacterial infections were seen in 5 patients. Viral infections were seen in 4 patients. Scabies was seen in 2 patients. Sparse scalp hair was reported in 7. Specific nail changes were seen in 19 patients. CONCLUSIONSAmong the various cutaneous manifestations, xerosis and pigmentary changes topped the list of prevalence with Xerosis 56%, Pallor 28%. Pruritus was seen in 24% of patients. Nearly, 6% had perforating dermatosis. The Prevalence of hair abnormalities in our study was 14%. Prevalence of nail changes were seen in 38% of cases. Cutaneous infections were seen in 36% of patients.

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“…9 Pigmentation in HD patients could also be attributed to betaMelanocyte stimulating hormone. 10 In our study majority of patients had hyperpigmentation over sun exposed areas.…”

Section: Discussionmentioning

confidence: 45%

Profile of Skin Changes and Its Association With Biochemical Parameters in Haemodialysis Patients

Bakthavatchalu¹,

Kombettu²,

Betkerur³

et al. 2016

jemds

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Role of the kidney in regulating plasma immunoreactive beta-melanocyte-stimulating hormone.

Cited by 46 publications

References 5 publications

Elevated Plasma Levels of Opioid Peptides and Delta Sleep-Inducing Peptide but Not of Corticotropin-Releasing Hormone in Patients Receiving Chronic Hemodialysis

Elevated Plasma Levels of Opioid Peptides and Delta Sleep-Inducing Peptide but Not of Corticotropin-Releasing Hormone in Patients Receiving Chronic Hemodialysis

A Clinical Study of Cutaneous Manifestations of Chronic Kidney Disease

Profile of Skin Changes and Its Association With Biochemical Parameters in Haemodialysis Patients

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