Role of the Lateral Prefrontal Cortex in Executive Behavioral Control

Tanji, Jun; Hoshi, Eiji

doi:10.1152/physrev.00014.2007

Cited by 391 publications

(308 citation statements)

References 289 publications

(210 reference statements)

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“…Future studies that examine how brain activation changes pretreatment to posttreatment are needed to address these questions. It should also be noted that lateral PFC is involved in a range of executive functions (Tanji and Hoshi, 2008), and dlPFC is essential for manipulating information in working memory (Barbey et al, 2013). Thus it is possible that greater lateral PFC activation in the current study corresponds with greater attentional control or ability to maintain the goal of face matching in the presence of threat.…”

Section: Discussionmentioning

confidence: 74%

Prefrontal Reactivity to Social Signals of Threat as a Predictor of Treatment Response in Anxious Youth

Kujawa

Swain

Hanna

et al. 2015

Neuropsychopharmacol

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Neuroimaging has shown promise as a tool to predict likelihood of treatment response in adult anxiety disorders, with potential implications for clinical decision-making. Despite the relatively high prevalence and emergence of anxiety disorders in youth, very little work has evaluated neural predictors of response to treatment. The goal of the current study was to examine brain function during emotional face processing as a predictor of response to treatment in children and adolescents (age 7-19 years; N = 41) with generalized, social, and/ or separation anxiety disorder. Prior to beginning treatment with the selective serotonin reuptake inhibitor (SSRI) sertraline or cognitive behavior therapy (CBT), participants completed an emotional faces matching task during functional magnetic resonance imaging (fMRI). Whole brain responses to threatening (ie, angry and fearful) and happy faces were examined as predictors of change in anxiety severity following treatment. Greater activation in inferior and superior frontal gyri, including dorsolateral prefrontal cortex and ventrolateral prefrontal cortex, as well as precentral/postcentral gyri during processing of threatening faces predicted greater response to CBT and SSRI treatment. For processing of happy faces, activation in postcentral gyrus was a significant predictor of treatment response. Post-hoc analyses indicated that effects were not significantly moderated by type of treatment. Findings suggest that greater activation in prefrontal regions involved in appraising and regulating responses to social signals of threat predict better response to SSRI and CBT treatment in anxious youth and that neuroimaging may be a useful tool for predicting how youth will respond to treatment.

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Section: Discussionmentioning

confidence: 74%

Prefrontal Reactivity to Social Signals of Threat as a Predictor of Treatment Response in Anxious Youth

Kujawa

Swain

Hanna

et al. 2015

Neuropsychopharmacol

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“…Previous studies reported that the dorsolateral PFC participates in a range of processes related to executive behavioral control (32)(33)(34)(35). Among them, the role of the lateral PFC in response-guiding rules and strategies is of particular relevance to the present study.…”

Section: Discussionmentioning

confidence: 78%

Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics

Matsuzaka

Akiyama

Tanji

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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The functional roles of the primate posterior medial prefrontal cortex have remained largely unknown. Here, we show that this region participates in the regulation of actions in the presence of multiple response tactics. Monkeys performed a forelimb task in which a visual cue required prompt decision of reaching to a left or a right target. The location of the cue was either ipsilateral (concordant) or contralateral (discordant) to the target. As a result of extensive training, the reaction times for the concordant and discordant trials were indistinguishable, indicating that the monkeys developed tactics to overcome the cue-response conflict. Prefrontal neurons exhibited prominent activity when the concordant and discordant trials were randomly presented, requiring rapid selection of a response tactic (reach toward or away from the cue). The following findings indicate that these neurons are involved in the selection of tactics, rather than the selection of action or monitoring of response conflict: (i) The response period activity of neurons in this region disappeared when the monkeys performed the task under the behavioral condition that required a single tactic alone, whereas the action varied across trials. (ii) The neuronal activity was found in the dorsomedial prefrontal cortex but not in the anterior cingulate cortex that has been implicated for the response conflict monitoring. These results suggest that the medial prefrontal cortex participates in the selection of a response tactic that determines an appropriate action. Furthermore, the observation of dynamic, task-dependent neuronal activity necessitates reconsideration of the conventional concept of cortical motor representation.cortical plasticity | frontal executive function T he primate dorsomedial prefrontal cortex (PFC), and particularly its posterior region (pmPFC), is intimately connected with higher-order cortical motor areas in the frontal lobe, including the presupplementary motor area (pre-SMA), the rostral cingulate motor area, and the dorsal premotor area (1-4). This relationship with cortical motor areas resembles connections from the dorsolateral PFC (dlPFC), suggesting that both areas influence downstream motor areas during the selection, preparation, and execution of actions (5-8). Despite numerous studies demonstrating the involvement of the dlPFC in various aspects of behavioral control (9-12), however, little is known about the role of the pmPFC in the performance of motor behaviors.A few studies have attempted to explore this area. For example, Petrides proposed that the dorsomedial PFC plays important roles in monitoring multiple events and self-ordering actions (13), although his later study suggested that the dlPFC is also involved in this process (14). Bon and Lucchetti reported that electrical stimulation in area 8b evoked ear or eye movements, and neurons in this region showed activity modulation related to these types of movements (15, 16). Human brain-imaging studies identified active areas including the mPFC that were re...

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“…The PFC primarily includes the dorsolateral prefrontal (DLPFC), ventrolateral prefrontal cortex (VLPFC), orbital frontal cortex (OFC) and the medial prefrontal cortex (MPFC). The PFC is an executive system and coordinating center of psychological activity, and this area exhibits different activation patterns during most higher psychological processes [3][4][5][6]. Insight, which is a thinking process, is undoubtedly associated with the PFC.…”

Section: Prefrontal Cortex (Pfc)mentioning

confidence: 99%

New advances in the neural correlates of insight: A decade in review of the insightful brain

et al. 2012

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The first neuroimaging study of real-time brain activity during insight problem solving was conducted almost ten years ago. Many subsequent studies have used high-resolution event-related potentials (ERPs) and event-related functional magnetic resonance imaging (fMRI) to investigate the temporal dynamics and neural correlates of insight. Recent results on the neural underpinnings of insight have led researchers to propose a neural framework referred to as the "insightful brain". This putative framework represents the neural basis of the cognitive and affective processes that are involved in insight. The insightful brain may involve numerous brain regions, including the lateral prefrontal cortex, cingulate cortex, hippocampus, superior temporal gyrus, fusiform gyrus, precuneus, cuneus, insula and cerebellum. Functional studies have demonstrated that the lateral prefrontal cortex is responsible for mental set shifting and breaking during insight problem solving. The cingulate cortex is involved in the cognitive conflict between new and old ideas and progress monitoring. The hippocampus, superior temporal gyrus and fusiform gyrus form an integrated functional network that specializes in the formation of novel and effective associations. The effective transformation of problem representations depends on a non-verbal visuospatial information-processing network that comprises the precuneus and cuneus. The insula reflects cognitive flexibility and the emotional experience that is associated with insight. The cortical control of finger movements relies on the cerebellum. insight problem solving, insightful brain, creative thinking, neuroimaging, event-related potentials

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Role of the Lateral Prefrontal Cortex in Executive Behavioral Control

Cited by 391 publications

References 289 publications

Prefrontal Reactivity to Social Signals of Threat as a Predictor of Treatment Response in Anxious Youth

Prefrontal Reactivity to Social Signals of Threat as a Predictor of Treatment Response in Anxious Youth

Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics

New advances in the neural correlates of insight: A decade in review of the insightful brain

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