Role of the lower esophageal sphincter and hiatal hernia in the pathogenesis of gastroesophageal reflux disease

Helicobacter pylori infection and hiatal hernia do not affect acid reflux and esophageal motility in patients with gastro-esophageal reflux

“…6 HH was diagnosed endoscopically when the distance between the crural impression and the gastroesophageal junction was 2 cm or more, as stated by other authors. 7 Third, the patient had to exhibit H. pylori infection. To investigate H. pylori infection, we performed the urease test with a campylobacter-like organism (CLO) test kit.…”

A novel endoesophageal magnetic device to prevent gastroesophageal reflux

“…These characteristics of the HPZ are considered sufficient to prevent GER. In fact the LES pressure able to impede GER, even during transient increases in intra-abdominal pressure, was demonstrated to be around 10 mmHg [6] with a length of at least 2 cm [7], whereas the maximal yield pressure at which the cardias opens in GER patients was found to be 6 mmHg [8].…”

The role of esophageal motility and hiatal hernia in esophageal exposure to acid

“…Fein et al [6] similarly identified a hiatal hernia as an independent predictor of abnormal esophageal acid exposure. Although it is no longer true that an incompetent cardia results from a hiatal hernia, it has been shown that LES function, esophageal acid exposure, and the degree of mucosal injury are affected by the presence of a hiatal hernia [13].…”