“…20 Various microbial pathogens use the host's inhibitory SOCS proteins for manipulating cytokine receptor signaling, a helpful strategy to evade otherwise detrimental immune responses. Interestingly, located upstream of the CLEC16A gene is the human class II transactivator MHC2TA gene, and a haplotype conformed by two polymorphisms in the latter (rs3087456 and rs4774) was recently found associated with rheumatoid arthritis and MS. 21 Although no overall association with IBD was detected, stratification of CD patients by NOD2/CARD15 polymorphisms could evidence an effect. The obvious question that arises is why this locus was overlooked in the recent largest GWA study for CD.…”