Role of the Microbiology Laboratory in Diagnosis and Management of Pharyngitis

Bourbeau, Paul P.

doi:10.1128/jcm.41.8.3467-3472.2003

Cited by 31 publications

(22 citation statements)

References 43 publications

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“…Although recognized as a cause of a life-threatening illness starting with a sore throat, F. necrophorum has not been considered an important primary pathogen in the throat, and is rarely mentioned in literature on the subject (Bourbeau, 2003). In this study, however, we detected F. necrophorum in 10 % of symptomatic patients, a frequency that was second only to Group A streptococcus.…”

Section: Discussioncontrasting

confidence: 35%

Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice

Aliyu

Marriott

Curran

et al. 2004

Journal of Medical Microbiology

138

100

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Section: Discussioncontrasting

confidence: 35%

Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice

Aliyu

Marriott

Curran

et al. 2004

Journal of Medical Microbiology

138

100

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“…Centor's criteria (oral temperature C38.3°C, tonsillar exudate, absence of cough, and enlarged cervical lymph nodes) are commonly used to estimate the probability of GAS infection in patients with acute tonsillitis [5,6] and thus guide clinicians if a RADT should be performed (generally recommended in patients who meet 2-4 of Centor's criteria). The reliability of the RADT is high (sensitivity 83-94 % and specificity 97-100 %) and the test result is available within a few minutes [6,7]. However, the RADT only provides information concerning GAS and the widespread diagnostic reliance on this test by (Danish) general practitioners may leave other bacterial pathogens undetected and untreated, which may be one of the reasons for the very high incidence rate of peritonsillar abscess in Denmark [8].…”

Section: Introductionmentioning

confidence: 99%

Clinical and biochemical characteristics of patients with Fusobacterium necrophorum-positive acute tonsillitis

Kjaerulff

Thomsen

Ovesen

et al. 2015

Eur Arch Otorhinolaryngol

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Fusobacterium necrophorum (FN) is the predominant pathogen in peritonsillar abscesses, which is a relatively frequent complication of acute tonsillitis. The study aimed to explore if FN is a significant pathogen in acute tonsillitis, examine the prevalence of FN in acute tonsillitis patients, and describe the clinical and biochemical characteristics of FN-positive patients. A 6-month prospective study was conducted in a Danish general practice with eight physicians. One hundred acute tonsillitis patients and 100 healthy controls aged 15-40 years were included in the study. The prevalence of FN was (non-significantly) higher among acute tonsillitis patients (16 %) compared to healthy individuals (9 %) (P = 0.199). This trend was border significant for patients aged 15-29 years (24 vs 9 %) (P = 0.050). Significantly, more FN-positive patients were men (75 %) compared to patients growing other bacteria (17 %) or mixed oral flora (27 %) (P < 0.001). Centor scores, individual clinical symptoms, and infection markers were similar between patient growing FN and mixed oral flora. FN is possibly a significant and prevalent pathogen in acute tonsillitis among teenagers and young adults. Patients with FN-positive acute tonsillitis do not seem to be more clinically or biochemically affected than patients without growth of bacterial pathogens.

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“…However, rigorous data to support this or indeed a role for F. necrophorum in uncomplicated tonsillitis have been lacking. Bourbeau (42), in a review of laboratory diagnosis of pharyngitis, made no reference to F. necrophorum or indeed anaerobes in general. Three recent studies are therefore of considerable interest.…”

Section: F Necrophorum and Sore Throatmentioning

confidence: 99%

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

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SUMMARYSummary:Human infection withFusobacterium necrophorumusually involvesF. necrophorumsubsp.funduliformerather thanF. necrophorumsubsp.necrophorum, which is a common pathogen in animals. Lemierre's syndrome, or postanginal sepsis, is the most common life-threatening manifestation. Tonsillitis is followed by septic thrombophlebitis of the internal jugular vein and then a septicemia with septic emboli in lungs and other sites. Recent evidence suggests thatF. necrophorumcan be limited to the throat and cause persistent or recurrent tonsillitis.F. necrophorumis unique among non-spore-forming anaerobes, first for its virulence and association with Lemierre's syndrome as a monomicrobial infection and second because it seems probable that it is an exogenously acquired infection. The source of infection is unclear; suggestions include acquisition from animals or human-to-human transmission. Approximately 10% of published cases are associated with infectious mononucleosis, which may facilitate invasion. Recent work suggests that underlying thrombophilia may predispose to internal jugular vein thrombophlebitis. Lemierre's syndrome was relatively common in the preantibiotic era but seemed to virtually disappear with widespread use of antibiotics for upper respiratory tract infection. In the last 15 years there has been a rise in incidence, possibly related to restriction in antibiotic use for sore throat.

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Role of the Microbiology Laboratory in Diagnosis and Management of Pharyngitis

Cited by 31 publications

References 43 publications

Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice

Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice

Clinical and biochemical characteristics of patients with Fusobacterium necrophorum-positive acute tonsillitis

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

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