Role of the microbiome in oral cancer occurrence, progression and therapy

Li, Zhengrui; Liu, Yuan; Zhang, Ling

doi:10.1016/j.micpath.2022.105638

Cited by 26 publications

(24 citation statements)

References 293 publications

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“…For these reasons, it is so important to avoid a dysbiotic condition. Oral dysbiosis produces a microecological imbalance into the oral cavity, promoting a cascade of pathophysiological events which affect both evolution, development, progression, and metastasis of cancers [ 39 ].…”

Section: Microbiota and Pathogenetic Mechanisms Underlying Oral Squam...mentioning

confidence: 99%

Microbiota and Oral Cancer as A Complex and Dynamic Microenvironment: A Narrative Review from Etiology to Prognosis

Pignatelli

Romei

Bondi

et al. 2022

IJMS

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A complex balanced equilibrium of the bacterial ecosystems exists in the oral cavity that can be altered by tobacco smoking, psychological stressors, bad dietary habit, and chronic periodontitis. Oral dysbiosis can promote the onset and progression of oral squamous cell carcinoma (OSCC) through the release of toxins and bacterial metabolites, stimulating local and systemic inflammation, and altering the host immune response. During the process of carcinogenesis, the composition of the bacterial community changes qualitatively and quantitatively. Bacterial profiles are characterized by targeted sequencing of the 16S rRNA gene in tissue and saliva samples in patients with OSCC. Capnocytophaga gingivalis, Prevotella melaninogenica, Streptococcus mitis, Fusobacterium periodonticum, Prevotella tannerae, and Prevotella intermedia are the significantly increased bacteria in salivary samples. These have a potential diagnostic application to predict oral cancer through noninvasive salivary screenings. Oral lactic acid bacteria, which are commonly used as probiotic therapy against various disorders, are valuable adjuvants to improve the response to OSCC therapy.

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Section: Microbiota and Pathogenetic Mechanisms Underlying Oral Squam...mentioning

confidence: 99%

Microbiota and Oral Cancer as A Complex and Dynamic Microenvironment: A Narrative Review from Etiology to Prognosis

Pignatelli

Romei

Bondi

et al. 2022

IJMS

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“…However, Hayes et al argued the opposite [27]. The HPV and Epstein-Barr virus (EBV) are two popular viruses associated with OSCC [28]. The number of patients with HPV-positive HNSCC has been increasing, especially those with pharyngeal cancer [29], and these patients present with a significantly better prognosis than patients with HPV-negative HNSCC under similar treatments.…”

Section: Oral Microbiota and Osccmentioning

confidence: 99%

“…Several advanced approaches can detect oral cancer, such as lab-on-chip, microfluidics, nanodiagnostics, liquid biopsy, omics technology, and synthetic biology [78]. To date, numerous studies have applied different methods to describe the differences in oral microbiota between normal tissue and OSCC sites [28,[79][80][81], including the surface of the tumor tissue, within the tumor, and saliva. Allan Radaic etc.…”

Section: Diagnosis and Gradingmentioning

confidence: 99%

Mechanisms and Potential Clinical Implications of Oral Microbiome in Oral Squamous Cell Carcinoma

Wang,

Gao

2023

Current Oncology

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Microorganisms in the oral cavity are abundant in the human body. At present, more than 700 species of oral microorganisms have been identified. Recently, a lot of literature has indicated that the oral microbiota plays an important role in the occurrence, development, and prognosis of oral squamous cell carcinoma (OSCC) through various mechanisms. And researchers are now trying to utilize oral microbiota in cancer diagnosis and treatment. However, few articles systematically summarize the effects of oral microbes in the diagnosis, treatment, and disease outcomes of oral cancer. Herein, we made a summary of the microbial changes at cancerous sites and placed more emphasis on the mechanisms by which the oral microbiome promotes cancerization. Moreover, we aimed to find out the clinical value of the oral microbiome in OSCC.

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“…This yeast can join with lactic acid bacteria to produce biofilm in their role of pathogenesis [3]. Presence of pathogenic microorganisms in oral cavity and their by-products from metabolism can affect immune response, leading to pathogenesis of oral diseases such as oral cancer [4]. Hence, it is essential to protect oral cavity from infection.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Anti-Oral Cancer, and Antimicrobial Activity of Medicinal Plant Extracts: Development of Mouthrinse Formulations

Nanasombat

2023

Trends Sci

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Nowadays, there is growing interest in using medicinal plants as antimicrobial agents to treat microbial infections in the oral cavity. This study was aimed to evaluate phytochemical properties, anti-oral cancer and antimicrobial activity against C. albicans and some potential oral lactic acid bacteria (Lactobacillus casei and Lactobacillus plantarum). Plant extracts including Cinnamomum verum (cinnamon), Acorus calamus (sweet flag), Hibiscus sabdariffa (roselle), Zingiber officinale (ginger) and Alpinia officinarum (lesser galangal) were tested and used to formulate mouthrinses for oral health care. Cinnamon extract possessed the highest phenolic, flavonoid and tannin content, and antioxidant activity (1,152.58 mg ascorbic acid equivalent/g by phosphomolybdenum assay and 39.64 % nitric oxide radical scavenging activity), while roselle extract had the highest total alkaloids. Only lesser galangal extract displayed anti-oral cancer activity with 97.83 % cytotoxicity. High performance liquid chromatography (HPLC) analysis revealed the presence of galangin and kaempferide in the lesser galangal rhizome extract. The cinnamon extract showed the strongest inhibitory activity against Candida albicans (4 mg/mL MIC). Cinnamon extract (24 mg/mL) and cinnamaldehyde (0.08 mol/L) exhibited the best killing effect and the highest cellular protein leakage in C. albicans. In addition, these plant extracts were used to develop mouthrinse formulations. The extracts of cinnamon and ginger at 10 % in mouthrinse formulations could strongly inhibit the growth of C. albicans. In comparison, 8 and 10 % roselle extracts showed the best inhibitory effect against Lactobacillus casei. In summary, cinnamon and lesser galangal were potential plants with antimicrobial, antioxidant, anti-biofilm and anti-oral cancer activities, and thus can be utilized to formulate oral care products. HIGHLIGHTS Lesser galangal was found to be a prominent anti-oral cancer plant Cinnamon was shown to be an interesting anti-Candida albicans plant Cinnamon, ginger and roselle extracts at 10 % in mouthrinse formulations exhibited strong antimicrobial activity. These plants can be used to incorporate into oral care products for treatment and prevention of oral diseases GRAPHICAL ABSTRACT

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Role of the microbiome in oral cancer occurrence, progression and therapy

Cited by 26 publications

References 293 publications

Microbiota and Oral Cancer as A Complex and Dynamic Microenvironment: A Narrative Review from Etiology to Prognosis

Microbiota and Oral Cancer as A Complex and Dynamic Microenvironment: A Narrative Review from Etiology to Prognosis

Mechanisms and Potential Clinical Implications of Oral Microbiome in Oral Squamous Cell Carcinoma

Antioxidant, Anti-Oral Cancer, and Antimicrobial Activity of Medicinal Plant Extracts: Development of Mouthrinse Formulations

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