Role of the microbiota in ileitis of a mouse model of inflammatory bowel disease—Glutathione peroxide isoenzymes 1 and 2‐double knockout mice on a C57BL background

Chu, Fong‐Fong; Esworthy, R. Steven; Shen, Binghui; Doroshow, James H.

doi:10.1002/mbo3.1107

Cited by 3 publications

(2 citation statements)

References 83 publications

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“…Contrarily, PRDX2 probe 39,729_at, PRDX4 probe 201,923_at, and PRDX6 probe 200,845_s_at, mice do not spontaneously acquire cancer (Hampton et al, 2018). In contrast, Gpx1/2 knockout animals are generally healthy in the lab despite being predisposed to ileocolitis during weaning and developing commensal microbiota-dependent ileal and colonic tumors by the age of 6 months (Chu et al, 2004;Chu et al, 2020).…”

Section: Oxidative Stress Increases Cancer Riskmentioning

confidence: 99%

From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

Afzal,

Abdul Manap,

Attiq

et al. 2023

Front. Pharmacol.

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Increased production and buildup of reactive oxygen species (ROS) can lead to various health issues, including metabolic problems, cancers, and neurological conditions. Our bodies counteract ROS with biological antioxidants such as SOD, CAT, and GPx, which help prevent cellular damage. However, if there is an imbalance between ROS and these antioxidants, it can result in oxidative stress. This can cause genetic and epigenetic changes at the molecular level. This review delves into how ROS plays a role in disorders caused by oxidative stress. We also look at animal models used for researching ROS pathways. This study offers insights into the mechanism, pathology, epigenetic changes, and animal models to assist in drug development and disease understanding.

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Section: Oxidative Stress Increases Cancer Riskmentioning

confidence: 99%

From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

Afzal,

Abdul Manap,

Attiq

et al. 2023

Front. Pharmacol.

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“…Numerous experimental and genome-wide association studies have revealed many genetic and environmental factors and IBD susceptibility genes that may affect innate immunity, T cell activation, and molecular mediators' regulation [2][3][4]. Gut commensal microbiota play a crucial role in mucosal immunology mechanisms that are implicated in chronic intestinal inflammation, and several studies have demonstrated a reduction of about 25% of microbiome diversity in patients with IBD and experimental models of colitis [5][6][7][8]. Despite the accumulated evidence on the role of this imbalance, defined as dysbiosis, in IBD, it is not clear whether dysbiosis is a causal factor or the result of chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?

Filidou¹,

Kolios²

2021

Pharmaceuticals

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Inflammatory bowel disease (IBD), Crohn’s disease, and ulcerative colitis are characterized by chronic and relapsing inflammation, while their pathogenesis remains mostly unelucidated. Gut commensal microbiota seem to be one of the various implicated factors, as several studies have shown a significant decrease in the microbiome diversity of patients with IBD. Although the question of whether microbiota dysbiosis is a causal factor or the result of chronic inflammation remains unanswered, one fact is clear; active inflammation in IBD results in the disruption of the mucus layer structure, barrier function, and also, colonization sites. Recently, many studies on IBD have been focusing on the interplay between mucosal and luminal microbiota, underlining their possible beneficial effect on mucosal healing. Regarding this notion, it has now been shown that specific probiotic strains, when administrated, lead to significantly decreased inflammation, amelioration of colitis, and improved mucosal healing. Probiotics are live microorganisms exerting beneficial effects on the host’s health when administered in adequate quantity. The aim of this review was to present and discuss the current findings on the role of gut microbiota and their metabolites in intestinal wound healing and the effects of probiotics on intestinal mucosal wound closure.

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Macrophage-Stimulating 1 Polymorphism rs3197999 in Pediatric Patients with Inflammatory Bowel Disease

Brylak,

Nowak,

Dybska

et al. 2024

Medicina

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Background and Objectives: Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), often necessitates long-term treatment and hospitalizations and also may require surgery. The macrophage-stimulating 1 (MST1) rs3197999 polymorphism is strongly associated with the risk of IBD but its exact clinical correlates remain under investigation. We aimed to characterize the relationships between the MST1 rs3197999 genotype and the clinical characteristics in children and adolescents with IBD within a multi-center cross-sectional study. Materials and Methods: Clinical data included serum C-reactive protein (CRP), albumin, activity indices (PUCAI, PCDAI), anthropometric data, pharmacotherapy details, surgery, and disease severity. Genotyping for rs3197999 was carried out using TaqMan hydrolysis probes. Results: The study included 367 pediatric patients, 197 with Crohn’s disease (CD) (40.6% female; a median age of 15.2 years [interquartile range 13.2–17.0]) and 170 with ulcerative colitis (UC) (45.8% female; a median age of 15.1 years [11.6–16.8]). No significant relationships were found between MST1 genotypes and age upon first biologic use, time from diagnosis to biological therapy introduction, PUCAI, PCDAI, or hospitalizations for IBD flares. However, in IBD, the height Z-score at the worst flare was negatively associated with the CC genotype (p = 0.016; CC: −0.4 [−1.2–0.4], CT: −0.1 [−0.7–0.8], TT: 0.0 [−1.2–0.7)]). The TT genotype was associated with higher C-reactive protein upon diagnosis (p = 0.023; CC: 4.3 mg/dL [0.7–21.8], CT 5.3 mg/dL [1.3–17.9], TT 12.2 mg/dL [3.0–32.9]). Conclusions: This study identified links between MST1 rs3197999 and the clinical characteristics of pediatric IBD: height Z-score and CRP. Further studies of the associations between genetics and the course of IBD are still warranted, with a focus on more extensive phenotyping.

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Role of the microbiota in ileitis of a mouse model of inflammatory bowel disease—Glutathione peroxide isoenzymes 1 and 2‐double knockout mice on a C57BL background

Abstract: Wild-type, transgenic, and gene knockout (KO) rodent models of inflammatory bowel disease (IBD) most often demonstrate depen

Cited by 3 publications

References 83 publications

From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?

Macrophage-Stimulating 1 Polymorphism rs3197999 in Pediatric Patients with Inflammatory Bowel Disease

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