Role of the Natriuretic Peptide System in Cardiorenal Protection

McFarlane, Samy I.; Winer, Nathaniel; Sowers, James R.

doi:10.1001/archinte.163.22.2696

Cited by 44 publications

(24 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Renal ischemia-reperfusion injury (8), impaired vasodilatation (9), neurohormonal activation (10), oxidative stress (11), inflammation (12), and atheroembolism (13) promote AKI following cardiac surgery and cardiopulmonary bypass. In contrast, statins limit oxidant production (14), improve endothelial function (15), and reduce inflammation (16).…”

Section: Introductionmentioning

confidence: 99%

Early Postoperative Statin Therapy Is Associated With a Lower Incidence of Acute Kidney Injury After Cardiac Surgery

Billings

Pretorius

Siew

et al. 2010

Journal of Cardiothoracic and Vascular Anesthesia

View full text Add to dashboard Cite

Objective-To test the hypothesis that perioperative statin use reduces acute kidney injury (AKI) following cardiac surgery Design-Retrospective analysis of prospectively collected data from an ongoing clinical trialSetting-Quaternary-care university hospital Participants-Three hundred twenty-four elective adult cardiac surgery patients Interventions-NoneMeasurements and Main Results-We assessed the association of preoperative statin use, early postoperative statin use, and acute statin withdrawal with the incidence of AKI. Early postoperative statin use was defined as statin treatment within the first postoperative day. Statin withdrawal was defined as discontinuation of preoperative statin treatment prior to surgery until at least postoperative day 2. Logistic regression and propensity score modeling were used to control for AKI risk factors. Sixty-eight of 324 patients (21.0%) developed AKI. AKI patients stayed in the hospital longer (P=0.03) and were more likely to develop pneumonia (P=0.002) or die (P=0.001). Higher body mass index (P=0.003), higher central venous pressure (P=0.03), and statin withdrawal (27.4 vs. 14.7%, P=0.046) were associated with a higher incidence of AKI, while early postoperative statin use was protective (12.5 vs. 23.8%, P=0.03). Preoperative statin use did not affect risk of AKI. In multivariate logistic regression, age (P=0.03), male gender (P=0.02), body mass index (P<0.001), and early postoperative statin use (OR 0.32, 95% CI 0.14-0.72, P=0.006) © 2010 Elsevier Inc. All rights reserved.Address for correspondence: Frederic T. Billings, IV, MD, 1211 21 st Avenue South, Suite 526, Nashville, TN 37212, Fax: 615-343-6272, Phone: 615-936-8487, frederic.t.billings@vanderbilt.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusions-Early postoperative statin use is associated with a lower incidence of AKI among both chronic statin users and statin-naïve cardiac surgery patients. NIH Public Access

show abstract

Section: Introductionmentioning

confidence: 99%

Early Postoperative Statin Therapy Is Associated With a Lower Incidence of Acute Kidney Injury After Cardiac Surgery

Billings

Pretorius

Siew

et al. 2010

Journal of Cardiothoracic and Vascular Anesthesia

View full text Add to dashboard Cite

show abstract

“…Functions of the NPS include the counter-regulation of RAS, and it is suggested that its activation provides organ protection in cardiorenal disease, especially in diabetic patients [43]. …”

Section: Resultsmentioning

confidence: 99%

Integrative Bioinformatics Analysis of Proteins Associated with the Cardiorenal Syndrome

Mühlberger

Moenks

Bernthaler

et al. 2011

International Journal of Nephrology

View full text Add to dashboard Cite

The cardiorenal syndrome refers to the coexistence of kidney and cardiovascular disease, where cardiovascular events are the most common cause of death in patients with chronic kidney disease. Both, cardiovascular as well as kidney diseases have been extensively analyzed on a molecular level, resulting in molecular features and associated processes indicating a cross-talk of the two disease etiologies on a pathophysiological level. In order to gain a comprehensive picture of molecular factors contributing to the bidirectional interplay between kidney and cardiovascular system, we mined the scientific literature for molecular features reported as associated with the cardiorenal syndrome, resulting in 280 unique genes/proteins. These features were then analyzed on the level of molecular processes and pathways utilizing various types of protein interaction networks. Next to well established molecular features associated with the renin-angiotensin system numerous proteins involved in signal transduction and cell communication were found, involving specific molecular functions covering receptor binding with natriuretic peptide receptor and ligands as well known example. An integrated analysis of identified features pinpointed a protein interaction network involving mediators of hemodynamic change and an accumulation of features associated with the endothelin and VEGF signaling pathway. Some of these features may function as novel therapeutic targets.

show abstract

“…The natriuretic peptide system consists of the ANP, the brain natriuretic peptide, and the C-type natriuretic peptide, each encoded by a separate gene [32]. They are synthesized predominantly in the heart, brain, and kidneys and act via specific receptors (NPr-A, NPr-B, and NPr-C) [14,32].…”

Section: Alterations In the Natriuretic Peptide Systemmentioning

confidence: 99%

Section: Alterations In the Natriuretic Peptide Systemmentioning

confidence: 99%

“…They are synthesized predominantly in the heart, brain, and kidneys and act via specific receptors (NPr-A, NPr-B, and NPr-C) [14,32]. The natriuretic peptides have a protective role on the development of HTN due to their natriuretic and vasodilatory effects as well as their inhibitory effect on the SNS and the RAAS [14,32]. It has been reported that in obesity and insulin-resistant states there are reduced levels and function of ANP with overexpression of NPr-C receptors, which may lead to increased sodium retention [14,33,34].…”

Section: Alterations In the Natriuretic Peptide Systemmentioning

confidence: 99%

See 1 more Smart Citation

Hypertension in people with diabetes and the metabolic syndrome: Pathophysiologic insights and therapeutic update

Ganne¹,

Arora²,

Dotsenko³

et al. 2007

Curr Diab Rep

Self Cite

View full text Add to dashboard Cite

Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are emerging as epidemics of the 21st century and are important components of the metabolic syndrome (MS). Evidence demonstrates a relationship between HTN, T2DM, and several vascular and metabolic abnormalities that are components of the MS. HTN affects nearly 70 million Americans and over one billion worldwide; likewise, the MS affects 44% of the US population above the age of 60 years and is rapidly increasing. HTN associated with the MS has certain pathophysiologic characteristics that provide clinical challenges. There is growing evidence that tissue activation of the renin-angiotensin system contributes to endothelial dysfunction, microalbuminuria, insulin resistance, and subsequent increased risk for cardiovascular and chronic kidney disease. The notion that HTN is a metabolic as well as a vascular disease provides a new treatment paradigm.

show abstract

Role of the Natriuretic Peptide System in Cardiorenal Protection

Cited by 44 publications

References 108 publications

Early Postoperative Statin Therapy Is Associated With a Lower Incidence of Acute Kidney Injury After Cardiac Surgery

Early Postoperative Statin Therapy Is Associated With a Lower Incidence of Acute Kidney Injury After Cardiac Surgery

Integrative Bioinformatics Analysis of Proteins Associated with the Cardiorenal Syndrome

Hypertension in people with diabetes and the metabolic syndrome: Pathophysiologic insights and therapeutic update

Contact Info

Product

Resources

About