Role of the neostriatal dopaminergic activity in sequencing and selecting behavioural strategies: Facilitation of processes involved in selecting the best strategy in a stressful situation

Cools, A.R.

doi:10.1016/s0166-4328(80)80073-8

Cited by 36 publications

(55 citation statements)

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“…The 9R carriers exhibited greater effects of reward on behavioral switch costs as well as on switch-related striatal activity than did 10R homozygotes. These findings reinforce the importance of the striatum for task switching (Cools, 1980;Cools et al, 2004;Leber et al, 2008;Lyon and Robbins, 1975;Oades, 1985), a process previously associated almost exclusively with the PFC (Sakai, 2008). Specifically, we show that the degree to which task switching is influenced by motivational state depends on genetic variation in the DAT, which is most abundant in the striatum, and is accompanied by modulation of activity in the striatum only.…”

Section: Discussionsupporting

confidence: 89%

“…In doing so, our results provide direct support for previously hypothesized neurochemical mechanism for the interface between motivation and cognition. The finding extends classic observations that behavioral flexibility depends on striatal dopamine (Cools, 1980;Lyon and Robbins, 1975;Oades, 1985) to the domain of human motivation and cognition, thus drawing attention to the importance of striatal dopamine for higher-order cognitive control processing.…”

Section: Role Of Dopamine In Motivation and Cognitionsupporting

confidence: 83%

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Striatal Dopamine Mediates the Interface between Motivational and Cognitive Control in Humans: Evidence from Genetic Imaging

Aarts

Roelofs

Franke

et al. 2010

Neuropsychopharmacol

146

131

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Dopamine has been hypothesized to provide the basis for the interaction between motivational and cognitive control. However, there is no evidence for this hypothesis in humans. We fill this gap by using fMRI, a novel behavioral paradigm and a common polymorphism in the DAT1 gene (SLC6A3). Carriers of the 9-repeat (9R) allele of a 40 base pair repeat polymorphism in the 3 0 untranslated region of DAT1, associated with high striatal dopamine, showed greater activity in the ventromedial striatum during reward anticipation than homozygotes for the 10-repeat allele, replicating previous genetic imaging studies. The crucial novel finding is that 9R carriers also exhibited a greater influence of anticipated reward on switch costs, as well as greater activity in the dorsomedial striatum during task switching in anticipation of high reward relative to low reward. These data establish a crucial role for human striatal dopamine in the modulation of cognitive flexibility by reward anticipation, thus, elucidating the neurochemical mechanism of the interaction between motivation and cognitive control.

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Section: Discussionsupporting

confidence: 89%

Section: Role Of Dopamine In Motivation and Cognitionsupporting

confidence: 83%

Striatal Dopamine Mediates the Interface between Motivational and Cognitive Control in Humans: Evidence from Genetic Imaging

Aarts

Roelofs

Franke

et al. 2010

Neuropsychopharmacol

146

131

View full text Add to dashboard Cite

show abstract

“…Neurophysiological findings have shown that NAc neurons encode a combination of outcomepredictive information and behavioral switching and may indicate that NAc neurons encode behavioral switching only when they encode outcome-predicting information (Wilson and Bowman, 2005). Those findings may reconcile our observation that the NAc is active during final reversal errors, which signal not only a behavioral switch but also an upcoming rewarding outcome, with previous findings that (i) the NAc subserves switching (Cools, 1980;Redgrave et al, 1999) and (ii) other neurophysiological and neuroimaging data showing NAc-activity during reward-anticipation (Hollerman and Schultz, 1998;Knutson et al, 2001;Carelli, 2004;Knutson et al, 2005).…”

Section: Discussionsupporting

confidence: 84%

L-DOPA Disrupts Activity in the Nucleus Accumbens during Reversal Learning in Parkinson's Disease

Cools

Lewis

Clark

et al. 2006

Neuropsychopharmacol

268

210

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Evidence indicates that dopaminergic medication in Parkinson's disease may impair certain aspects of cognitive function, such as reversal learning. We used functional magnetic resonance imaging in patients with mild Parkinson's disease to investigate the neural site at which L-DOPA acts during reversal learning. Patients were scanned both ON and OFF their normal dopamine-enhancing L-DOPA medication during the performance of a probabilistic reversal learning task. We demonstrate that L-DOPA modulated reversal-related activity in the nucleus accumbens, but not in the dorsal striatum or the prefrontal cortex. These data concur with evidence from studies with experimental animals and indicate an important role for the human nucleus accumbens in the dopaminergic modulation of reversal learning.

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“…In fact after the conditioning phase the animal is confronted with a conflicting situation: in the pre exposure phase drinking sucrose is without conse quence; however, after the conditioning phase sucrose drinking is associated with discomfort. It has been demonstrated that both the dorsal striatum and the nucleus accumbens are im portant in changing ongoing behaviour (Van den Berciceli and Cools 1982; Van den Bos and Cools 1989), In fact, whereas an increased dopamine activity of the dorsal striatum has been shown to improve the ability to switch arbitrarily (Cools 1980), an increased dopaminergic activity o f the nucleus accumbens has been shown to improve switch ing with the help of external stimuli (Van den Bos and Cools 1989). In the presently used conditioned taste aversion paradigm the hedonic value of sucrose is used as a stimulus, suggesting that the shift is primarily determined by interoceptive rather than exteroceptive (lights or tones) stimuli.…”

Section: H20mentioning

confidence: 99%

The role of mesolimbic and nigrostriatal dopamine in latent inhibition as measured with the conditioned taste aversion paradigm

Ellenbroek¹,

Knobbout²,

Cools³

1997

Psychopharmacology

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Repeatedly presenting a non-reinforced stim ulus normally retards conditioning to this stimulus when it is coupled to a reinforcer. This phenomenon is called latent inhibition. Since latent inhibition is disturbed after systemic administration of am pheta mine, the present study investigated the role of the mesolimbic and nigrostriatal dopamine terminal fields in latent inhibition using a conditioned taste aversion (CTA) paradigm. In this paradigm, a 5% sucrose solution was used as the test stimulus and lithium chloride (LiCl) as the CTA inducing drug. The degree of CTA was assessed by measuring the sucrose prefer ence in a two-bottle sucrose/water choice paradigm 24 h after the LiCl injection. Since conditioned taste aversion has so far not been used to evaluate the role of dopamine in latent inhibition, we first studied the effects of systemic application of amphetamine. The results show that intraperitoneal injections of 0.25 or 0.5 mg /leg ¿/-amphetamine sulphate (given at preexposure and conditioning) significantly disrupted latent inhibition, by selectively reducing sucrose preference in the preexposed group. This could not be attributed to a reduced sucrose intake during preex posure or to a conditioned taste aversion effect of am phetamine itself, In experiment 2 local bilateral administration of 10 |xg/0.5 jil amphetamine into the nucleus accumbens or the dorsal striatum was given in the pre-exposed and the conditioning phase, after which the rats were allowed to drink for a fixed period of time. The results show a significant reduction in latent inhibition after intrastriatal, but not after intra-accumbens injections of amphetamine. Intraaccumbens injections of amphetamine, however, significantly reduced fluid intake during preexposure and conditioning. In experiment 3, we therefore repeated this experiment, but allowed the animals to drink only a restricted am o u n t of liquid during preex posure and conditioning. Again the results show a dis ruption of latent inhibition after intrastriatal, but not intra-accumbens injections of amphetamine. These experiments emphasize the importance of the nigro striatal dopamine system in the disruption of latent inhibition, at least when using the conditioned taste aversion paradigm. A possible mechanism by which the dorsal striatum m ight influence latent inhibition is discussed.

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Role of the neostriatal dopaminergic activity in sequencing and selecting behavioural strategies: Facilitation of processes involved in selecting the best strategy in a stressful situation

Cited by 36 publications

References 0 publications

Striatal Dopamine Mediates the Interface between Motivational and Cognitive Control in Humans: Evidence from Genetic Imaging

Striatal Dopamine Mediates the Interface between Motivational and Cognitive Control in Humans: Evidence from Genetic Imaging

L-DOPA Disrupts Activity in the Nucleus Accumbens during Reversal Learning in Parkinson's Disease

The role of mesolimbic and nigrostriatal dopamine in latent inhibition as measured with the conditioned taste aversion paradigm

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