Role of the nitric oxide on rosuvastatin-induced relaxation of the calf cardiac vein during cooling

Abstract

Abstract:Objective: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors including rosuvastatin do not only lower plasma cholesterol but also have non-cholesterol lowering effects on the vessel wall, which decrease cardiovascular complications. The aim of the present study was to evaluate the effect of cooling (to 28 °C) on the vasodilatation induced by rosuvastatin (10 -9 -3x10 -4 M) on serotonin-pre-contracted calf cardiac vein and the role of nitric oxide in these effects. Material and methods: Ring preparations of veins obtained from calf hearts were suspended in organ baths containing 25 ml of Krebs-Henseleit solution, maintained at 37 °C and continuously gassed with 95% O 2 -5% CO 2 . After a resting period, preparations were contracted with serotonin (10 -6 M) at 37 °C. Results: Rosuvastatin produced concentration-dependent relaxation of calf cardiac vein precontracted with serotonin (10 -6 M). During cooling, the pIC 50 value, but not the maximal response, to rosuvastatin was signifi cantly higher than at 37 °C. Cooling to 28 °C in the presence of N G -nitro-L-arginine methyl ester (L-NAME, 10 -4 M) decreased the pIC 50 values to rosuvastatin. Conclusion:The results of the present study suggested that nitric oxide played an essential role in the coolinginduced changes of rosuvastatin in calf cardiac vein (Fig. 1, Ref. 23

Rosuvastatin relaxes rat thoracic aorta, pulmonary artery, and trachea via nitric oxide, prostanoids, and potassium channels

“…Guresir and Nurullahoglu determined that the NO pathway contributes to rosuvastatin-mediated cardiac vein relaxation 18 . In another study, it was reported that atorvastatin caused vasorelaxation in the rat thoracic aorta and the NO pathway played a role in this effect 16 .…”

Moderate hypothermia and responses to calcium channel blockers – Role of the nitric oxide

“…In this work, we studied the effects of moderate hypothermia on calcium channel blockersinduced vasodilatation of calf cardiac vein, paying special attention to the role of nitric oxide in these responses. The calf cardiac vein is an easily accessible smooth muscle preparation and there is limited information (12,19,20) about the effects of temperature in non-cutaneous vessels. Moreover, the effects of hypothermia were generally studied with contractile agents.…”