Role of the Nondominant Hemisphere and Undamaged Area During Word Repetition in Poststroke Aphasics

Ohyama, Masashi; Senda, Michio; Kitamura, Shin; Ishii, Kenji; Mishina, Masayoshi; Terashi, Akiro

doi:10.1161/01.str.27.5.897

Cited by 179 publications

(82 citation statements)

References 24 publications

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“…This hypothesis has even been used as the conceptual basis for several neuroimaging studies of lesion-related language disorders (e.g., Refs. 54,67,273,402,419). The contribution of specific right-sided regions in language recovery from aphasia has gained support from recent results.…”

Section: Language Recovery Poststrokementioning

confidence: 98%

Renewal of the Neurophysiology of Language: Functional Neuroimaging

Démonet¹,

Thierry²,

Cardebat³

2005

Physiological Reviews

371

207

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Functional neuroimaging methods have reached maturity. It is now possible to start to build the foundations of a physiology of language. The remarkable number of neuroimaging studies performed so far illustrates the potential of this approach, which complements the classical knowledge accumulated on aphasia. Here we attempt to characterize the impact of the functional neuroimaging revolution on our understanding of language. Although today considered as neuroimaging techniques, we refer less to electroencephalography and magnetoencephalography studies than to positron emission tomography and functional magnetic resonance imaging studies, which deal more directly with the question of localization and functional neuroanatomy. This review is structured in three parts. 1) Because of their rapid evolution, we address technical and methodological issues to provide an overview of current procedures and sketch out future perspectives. 2) We review a set of significant results acquired in normal adults (the core of functional imaging studies) to provide an overview of language mechanisms in the “standard” brain. Single-word processing is considered in relation to input modalities (visual and auditory input), output modalities (speech and written output), and the involvement of “central” semantic processes before sentence processing and nonstandard language (illiteracy, multilingualism, and sensory deficits) are addressed. 3) We address the influence of plasticity on physiological functions in relation to its main contexts of appearance, i.e., development and brain lesions, to show how functional imaging can allow fine-grained approaches to adaptation, the fundamental property of the brain. In closing, we consider future developments for language research using functional imaging.

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Section: Language Recovery Poststrokementioning

confidence: 98%

Renewal of the Neurophysiology of Language: Functional Neuroimaging

Démonet¹,

Thierry²,

Cardebat³

2005

Physiological Reviews

371

207

View full text Add to dashboard Cite

show abstract

“…Furthermore, more recent clinical studies have emphasized the role of the right hemisphere in spontaneous recovery of language (Thulborn, Carpenter, & Just, 1999;Mimura et al, 1998;Weekes, Coltheart, & Gordon, 1997;Ohyama et al, 1996;Weiller et al, 1995;Papanicolaou, Moore, Deutsch, Levin, & Eisenberg, 1988). Imaging results have shown shifts of activity to right hemisphere areas homotopic to the classical left hemisphere language areas (Ohyama et al, 1996;Weiller et al, 1995), overall stronger activity in the right than in the left hemisphere (Cao, Vikingstad, George, Johnson, & Welsch, 1999;Papanicolaou et al, 1988), or pronounced increase of right hemisphere activity during recovery (Thulborn et al, 1999). In all these studies, aphasic subjects were still in the process of spontaneous recovery (acute state).…”

Section: Role Of Right Hemisphere In Aphasia Recovery and Rehabilitationmentioning

confidence: 99%

“…So far, functional imaging of recovery of language functions in aphasia has largely concentrated on spontaneous recovery (Warburton, Price, Swinburn, & Wise, 1999;Karbe et al, 1998;Buckner, Corbetta, Schatz, Raichle, & Petersen, 1996;Ohyama et al, 1996;Engelein et al, 1995;Weiller et al, 1995;Heiss, Kessler, Karbe, Fink, & Pawlik, 1993;Heiss, Kessler, Thiel, Ghaemi, & Karbe, 1999;Demeurisse & Capon, 1987). The mechanisms of spontaneous recovery are likely to be different from those of training-induced recovery (cf.…”

Section: Introductionmentioning

confidence: 99%

Adult Brain Plasticity Elicited by Anomia Treatment

Cornelissen¹,

Laine

Tarkiainen³

et al. 2003

Journal of Cognitive Neuroscience

151

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Abstract& We describe a study where a specific treatment method for word-finding difficulty (so-called contextual priming technique, which combines massive repetition priming with semantic priming) was applied with three chronic left hemispheredamaged aphasics. Both before and after treatment, which focused on naming of a series of pictures, naming-related brain activity was measured by magnetoencephalography (MEG). Due to its excellent temporal resolution and good spatial resolution, we were able to track treatment-induced changes in cortical activity. All three subjects showed improved naming of the trained items. In all subjects, a single source area, located in the left inferior parietal lobe, close to the lesioned area, displayed statistically significant training-induced changes. This effect was of long latency as it started 300 -600 msec after picture presentation. The change in activation was specific to training, as it could not be accounted for by variation of cortical dynamics associated with increased proportion of correct answers. Our interpretation is that the training effect reflects more effective phonological encoding and storage of the trained items through the engagement of a left hemispheric word-learning system. This is in line with recent functional imaging studies, which have linked left inferior parietal lobe activity to the phonological storage component of the verbal working memory, as well as with theoretical arguments stating that the primary role of the phonological loop is to acquire new words. Finally, the MEG results showed no evidence of increased right hemisphere participation following training, supporting the view that restoration of language-related networks in the damaged left hemisphere is crucial for anomia recovery. &

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“…On the other hand, however, other reports have also emphasized the involvement of the right hemisphere in some language functional recovery in a subgroup of post-stroke patients. For example, in the PET study by Ohyama et al (1996), language functional recovery correlated significantly with the activation of the right hemisphere in non-fluent aphasic post-stroke patients. Using functional MRI with language tasks, Abo et al (2004) showed that complete recovery of aphasic symptoms was associated with significant activation of the right hemisphere.…”

Section: Are the Compensatory Areas For Impaired Language Function Unmentioning

confidence: 96%