Role of the Opioid System in the Modulation of Thermonociceptive Sensitivity of Mollusks Affected by Weak Electromagnetic Factors
Abstract: We studied the role of the opioid system in the modulation of thermonociceptive sensitivity of Helix albestens mollusks subjected within a 21-day-long period to the conditions of electromagnetic shielding, action of a weak extremely low-frequency oscillating magnetic field, and combination of the above factors. Results of blocking of opioid receptors by naloxone demonstrated that the efficacy of antonociceptive influences of the opioid system is dissimilar within different stages of action of the above electro… Show more
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Analgesic and Anti-Inflammatory Effects of Acetylsalicylic Acid: Physiological Mechanisms
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Analgesic and Anti-Inflammatory Effects of Acetylsalicylic Acid: Physiological Mechanisms
1. Vejn A. M., Pain syndromes in neurological practice, 368 p. (Moscow, MED-press-inform, 2001). 2. Vengerovskij A. I., Lectures on Pharmacology, 390 p. (Tomsk, SibGMU, 2007). 3. Sapegin I. D., Basic pharmacology, 122 p. (KSMU, Simferopol, 2012). 4. Vertkin A. L., Naumov A. V., Shamuilova M. M., Ivanov V. S., Sugaipov A. A., Otpushenko A. A., Dilemma of choice of non-steroidal anti-inflammatory drugs in therapeutic practice, Klinicist, 8, 2, 46 (2008). 5. Katyushina O. V., Cheretaev I. V., Berezhnev L. Yu., Shilina V. V., Husainov D. R., Gamma T. V., The severity of antidepressant and analgesic effects of aspirin and its derivatives in a wide range of doses, 77th final scientific-practical conference with international participation, Krasnoyarsk, 23-26 April 2013, pp. 427-429 (Krasnoyarsk, KrasGMU-Verso, 2013). 6. Katyushina O. V., Mechanisms of the physiological effect of ultrasmall doses of aspirin and its derivatives, 150 p. (Simferopol, TNU, 2013). 7. Mashkovskij M. D., Medicines of the ХХ century, 320 p. (Izdatel'stvo Novaya Volna, Moscow, 1998). 8. Dejl M. M., Formen K., Guidelines for Immunopharmacology, (Moscow, Medicina, 1998). 9. Mashkovskij M. D., Acetilsalicilovaya kislota v ryadu sovremennyh lekarstvennyh sredstv, Him.-farm. zhurn., 28, 2, 4 (1994). 10. Mashkovskij M. D., Lekarstvennye sredstva: v 2 t., 1, 540 p. (Moscow, Izdatel'stvo Novaya Volna, 2002). 11. Osipova N. A., Abuzarova G. R., Petrova V. V., Principles of using analgesics for acute and chronic pain, 67 p. (Moscow, MNIOI, 2010). 12. Kovalenko V. N., Viktorov A. P., Compendium - 2005 – drugs, 1920 p. (Kiev, Morion, 2005). 13. Katyushina O. V., Yakovchuk T. V., Korenyuk I. I., Husainov D. R., Gamma T. V., Cheretaev I. V., Effect of Ultra-low Doses Aspirin, Acetylsalicylate Cobalt and Zinc on Pain Sensitivity Rats, Uspekhi sovremennogo estestvoznaniya, 9, 28 (2012). 14. Katyushina O. V., Shilina V. V., Korenyuk I. I., Gamma T. V., Cheretaev I. V., Changing the pain threshold under the action of aspirin and analgin in standard and ultra-low doses, Wpływ badań naukowych: zbiór raportów naukowych Miedzynarodowej Naukowi-Praktycznej Konferencji, Bydgoszcz (28.04-30.04.2013), 1, 71 (Warszawa, Diamond trading tour, 2013). 15. Katyushina O. V., Cheretaev I. V., Husainov D. R., Gamma T. V., Analgesic effect of ultra-low doses of aspirin and its salts on the background of D2-receptor blockade, Vestnik Permskoj gosudarstvennoj farmacevticheskoj akademii, 1, 10, 59 (2013). 16. Katyushina O. V., Korenyuk I. I., Husainov D. R., Gamma T. V., Cheretaev I. V., Shul'gin V. F., Analgesic effect of ultra-low doses of aspirin against the background of oppression and stimulation of the dopaminergic system, Proceedings of the IX international scientific and technical conference "Actual problems of biological physics and chemistry – 2013", April 23-27, 2013, 141 (SevNTU, Sevastopol', 2013). 17. Katyushina O. V., Husainov D. R., Korenyuk I. I., Gamma T. V., Cheretaev I. V., Kolotilova O. I., Anti-inflammatory activity of acetylsalicylic acid and its salts, X Mіzhnarodnі Novorіchnі bіologіchnі chitannya, 10, 186 (2010). 18. Benedito M. A., Gender differences in the activities of aspirin-esterases in rat tissues, Braz. J. Med. Biol. Res., 31, 9, 1113 (1998). 19. Colby H. D., Regulation of hepatic drug and steroid metabolism by androgens and estrogens, Advances in Sex Hormone Research, J. A. Thomas, R. L. Signal eds., 4, 27 (Baltimore, Urban and Schwartzenberg, 1980). 20. Gustafsson J. A., Mode A., Norstedt G., Skett P., Sex steroid induced changes in hepatic enzymes, Annual Review of Physiology, 45, 51 (1983). 21. Kennedy M. J., Hormonal regulation of hepatic drug-metabolizing enzyme activity during adolescence, Clinical Pharmacology and Therapeutics, 84, 6, 662 (2008). 22. Miners J. O., Grgurinovich N., Whitehead A. G., Robson R. A., Birkett D. 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