Role of the osteocyte in bone metastasis – The importance of networking

Verbruggen, Stefaan W.

doi:10.1016/j.jbo.2024.100526

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…Метастатичні ураження кісток є складними клінічними станами, які виникають у результаті міграції та колонізації ракових клітин з їхнього основного місця в кісткове мікрооточення, де вони, зазвичай, розвивають метастатичну нішу [1]. Онкологічне ураження передміхурової залози є другою за поширеністю причиною злоякісних новоутворень у чоловіків, причому метастази в кістки -джерело захворюваності та смертності в запущених випадках [2,3].…”

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The Use of a Training 3d-Model in the Treatment of a Patient With a Pathological Fracture of the Proximal Part of the Femur (Case From Practice)

Drobotun,

Konovalenko,

Ternovyi

2024

OTP

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Prostate cancer is the second most common cause of malignancy in men, with bone metastases being a significant source of morbidity and mortality in advanced cases. Objective. To give a clinical example of a patient with a pathological transtrochanteric fracture of the right femur with displacement of fragments, the presence of metastasis at the fracture site, to emphasize the importance of 3D-training before surgery. Methods. A clinical example with a significant impairment of the function of the right lower extremity against the background of a significant pain syndrome is given. The diagnosis was established: pathological transtrochanteric fracture of the right femur with displacement of fragments, the presence of metastasis at the fracture site. Pre-surgical training was carried out using a 3D-model and total endoprosthetics of the right hip joint with a revision individual implant of the cement fixation type was carried out. The patient fully recovered the function of the right lower limb and hip joint, the pain syndrome was eliminated, and sleep normalized. The use of a 3D-model for preoperative training of surgeons made it possible to rationally limit traumatization of healthy tissues during tumor removal, prevent possible complications and optimize the time of surgical intervention and thus minimize blood loss. Conclusions. The use of a training 3D-model before surgery followed by prosthetics with a special oncological endoprosthesis provided satisfactory functional results and restoration of the patient's quality of life in the given clinical case. The use of a 3D-model is the key to careful preparation for surgical intervention, taking into account the individual anatomical features of the pathological process and adjacent tissues, which allows you to significantly optimize the terms of the operation and reduce blood loss, and also provides valuable experience for further surgical practice.

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