Role of the Power Function Value in Linearity and Universality for Charged Aerosol Detectors: Theoretical Elucidations from a Validated Model
Troy T. Handlovic,
Daipayan Roy,
Wesley W. Barnhart
et al.
Abstract:High-throughput drug discovery on the microgram scale is now common, making analyte quantitation without molecule-specific calibration imperative. The charged aerosol detector (CAD) was invented to be a next-generation universal liquid chromatography (LC) detector with excellent response universality for nonvolatile analytes as well as sensitivity for nonchromophoric compounds. Although the CAD is a mass flowsensitive detector, its response to mass is inherently nonlinear, which challenges traditional quantita… Show more
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