Role of the prostate in the regulation of pituitary secretion of follicle stimulating hormone

Ar, Sheth; Vanage, Geeta; Hurkadli, K. S.; Sheth, NA

doi:10.1016/0306-9877(84)90119-1

Cited by 12 publications

(5 citation statements)

References 13 publications

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“…This is consistent with identity/similarity with seminal &globulin, since the latter has an extragonadd origin, being synthesized by prostatic epithelial cells and found in increased concentrations in serum of patients with prostatic cancer [6]. In fact, prostatic origin of inhibin-like peptides has also been independently indicated [14]. Furthermore, observations on recoveries during purification of present inhibin preparations the amount of inhibin is larger than might normally be expected for a peptide with only hormonal function; the amount of the inhibin-like peptide is therefore consistent with it being a seminaf plasma &globulin [6].…”

Section: Inhibin Us a Sperm-coating Antigtmsupporting

confidence: 76%

Analysis of an inhibin preparation reveals apparent identity between a peptide with inhibin‐like activity and a sperm‐coating antigen

et al. 1984

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The amino acid sequence of a large form of inhibin‐like peptide in human seminal plasma was determined, and compared with structures reported for similar inhibin preparations and a seminal plasma globulin. The data confirm and correlate previous reports on this form of inhibin‐like peptide. The structural comparisons further suggest that the peptide is closely similar to or possibly identical to a sperm‐coating antigen reported to be synthesized from prostatic epithelium. This may correlate with non‐gonadal origins of inhibin‐like material and will help to elucidate the biological roles of inhibin(s).

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Section: Inhibin Us a Sperm-coating Antigtmsupporting

confidence: 76%

Analysis of an inhibin preparation reveals apparent identity between a peptide with inhibin‐like activity and a sperm‐coating antigen

et al. 1984

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“…Administration of antibodies to HSPI in adult male rats elevates the FSH levels 5-~o 7-fold, indicative of neutralization of endogenous inhibin by these antibodies to prostatic inhibin [21]. These studies, as well as other evidence [22], are suggestive of the role of the prostate as well as of the gonads in the physiological regulation of FSH. The present investigations demonstrate that the specific antiserum generated against homogenous inhibin preparation with 94 amino acids causes agglutination.…”

Section: Discussionmentioning

confidence: 89%

Antibodies to human seminal plasma inhibin cause sperm agglutination and impairment of cervical mucus penetration and sperm-egg attachment

1987

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Inhibin isolated from human seminal plasma which has 94 amino acids has been shown to be structurally similar to a sperm coating antigen of prostatic origin. Specific antibodies generated against this peptide caused agglutination of human sperm. Using FITC-labeled antibody, antigen was localized on the post-acrosomal head region of sperm. Antiserum to inhibin could also impair the penetration of human spermatozoa into cervical mucus. After 10 and 30 minutes, the depth and density of penetration as well as the motility of the sperm were inhibited. The treatment of sperm with antiserum to inhibin caused an inhibition of sperm attachment to the egg as well as inhibition of penetration.

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“…The prostate has been demonstrated to be a source of a number of regulatory peptides such as thyroid-releasing hormone (TRH) [ 11, endorphin [2], adenocorticotrophic hormone (ACTH) [3], and inhibin [4]. However, the physiological role, if any, of these prostatic peptides in the modulation of pituitary function is unelucidated.…”

Section: Introductionmentioning

confidence: 99%

Involvement of prostate in the regulation of serum levels of FSH, LH, and prolactin in male rats

et al. 1986

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Circulatory levels of LH and FSH were measured in serum of male rats (28, 35, 42, 63, 70, 77, and 207 days of age) 7 days following sham operation, castration (C), prostatectomy (P), and castration + prostatectomy (C + P). In C + P rats that were 49, 63, 70, 77, and 207 days of age, the plasma FSH was significantly elevated as compared to the C group. Administration of aqueous prostatic extract restored the circulatory FSH level in C + P animals to that observed in C animals, whereas in C animals FSH levels were suppressed, indicating inhibinlike activity. In rats 49 and 77 days of age, circulatory LH levels were significantly suppressed in C + P animals as compared to the C group. Both castration and prostatectomy alone suppressed circulatory prolactin levels. Administration of prostatic extract to castrated animals restored the prolactin levels to that of the sham-operated control animals. Results of the present study suggest a role of the prostate in feedback regulation of FSH and prolactin.

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Role of the prostate in the regulation of pituitary secretion of follicle stimulating hormone

Cited by 12 publications

References 13 publications

Analysis of an inhibin preparation reveals apparent identity between a peptide with inhibin‐like activity and a sperm‐coating antigen

Analysis of an inhibin preparation reveals apparent identity between a peptide with inhibin‐like activity and a sperm‐coating antigen

Antibodies to human seminal plasma inhibin cause sperm agglutination and impairment of cervical mucus penetration and sperm-egg attachment

Involvement of prostate in the regulation of serum levels of FSH, LH, and prolactin in male rats

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