Halogen Occultation Experiment (HALOE) data are used to study the quasi-biennial variability of CH 4 mixing ratio in the middle stratosphere. The results of EOF analysis indicate that quasi-biennial period is principal for the interannual variability of methane. Antisymmetry with respect to the equator is significant for the methane QBO by explaining 59.3% variance, while the symmetric component only explains about 30%. The antisymmetry is more significant in 10°-20° latitude than between 10ºS and 10ºN. Analyses of the vertical motions show that anomalies of annual cycle play an important role in the antisymmetric distributions. Whereas, the zonal wind QBO is still the most important dynamical effect for the interannual variability of CH 4 between 10°S-10°N.As one of the important green-house gases, methane in the stratosphere affects the stratospheric processes of radiation, dynamics and chemistry, even the tropospheric circulation through interactions between the stratosphere and the troposphere.To a great degree, methane sources and sinks determine their distribution in the stratosphere. Furthermore, some effects on methane sources or sinks will change the distribution. Wang [1] pointed out that methane emission from rice field and wetlands can be 1-3 times higher under elevated CO 2 condition than that in the ambient CO 2 condition (about 40% of CH4 is released from rice paddies and natural wetlands within the total world CH 4 budget). Zhang and Wang [2] used a two-dimensional global chemical model to investigate the cause of a dramatic decrease in the growth rate of CH 4 in 1992, and the results show that the decrease of CO emissions is a main cause accounting for about 27% except for the influences of CH 4 sources. Considine et al. [3] used the Goddard Space Flight Center interactive two-dimensional model to evaluate the effects of the Mount Pinatubo volcanic aerosol cloud on subsequent trends in upper stratospheric CH 4 and H 2 O. The simulated negative upper stratospheric trend of CH 4 between 1992 and 1997 is in better agreement with observations than a nonvolcanic simulation, but is still substantially weaker than the observations in the upper stratosphere by the Halogen Occultation Experiment (HALOE) between 1992 and 1997. Those comparisons suggest that the aerosol from the Mount Pinatubo eruption could have contributed to the observed changes in CH 4 following the eruption, but was probably not the sole driver of the observed changes.Dynamical processes also control the CH 4 distributions in the stratosphere. Nedoluha et al. [4] found a decreases in the middle-upper stratospheric CH 4 between 1991 and 1997 when they had analyzed the HALOE methane data, and the simulation results by a two-dimensional model show that the decreases of tropical ascending flow would cause the CH 4 decreases. Zhang et al. [5] used a SOCRATES model (interactive chemical, dynamical and radiative two-dimensional model) to study the impact of the zonal wind QBO on the distribution of the stratospheric tracer gases, and the resu...