Role of the Rosa canina L. leaf extract as an antidiarrheal drug in rodents

Mandade, Rajesh; Choudhury, Avijit; Harsulkar, Amol; Wakade, R.B.

doi:10.4103/0253-7613.81510

Cited by 11 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…27 Different authors also reported total phenolic content, total flavonoid content, as well as total flavonol aglycone levels in the leaf extracts of various Rosa species. 27 Different authors also reported total phenolic content, total flavonoid content, as well as total flavonol aglycone levels in the leaf extracts of various Rosa species.…”

Section: Chemical Analysismentioning

confidence: 99%

Rosa canina L. – new possibilities for an old medicinal herb

Živković¹,

Stojković

Petrović

et al. 2015

Food Funct.

View full text Add to dashboard Cite

Health beneficial properties of Rosa canina species are mainly attributed to rose hips, while the leaves are usually discarded as waste. In the present study we investigated chemical constituents as well as antimicrobial and antibiofilm potential of R. canina methanolic leaf extract. Chemical analysis showed that dominant phenolic compounds are quercetin and isorhamnetin derivatives (isoquercetin and isorhamnetin-3-O-rutinoside). Among the tested bacteria, Pseudomonas aeruginosa and Salmonella typhimurium were the most susceptible to the activity of R. canina leaf extract with MIC and MBC values both 0.009 mg mL −1 . For most of the bacterial strains investigated the extract showed significantly higher activity compared to the used standard compounds streptomycin and ampicillin. Also the tested extract powerfully inhibited in vitro biofilm growth in Pseudomonas aeruginosa, Staphylococcus aureus, Leishmania monocytogenes and Escherichia coli at sub MIC-levels. With concentrations equal to 1/4 and 1/8 of MIC values biofilm growth of P. aeruginosa and E. coli was inhibited by 90%. The obtained results are significant for a wider and efficient use of R. canina leaves.

show abstract

Section: Chemical Analysismentioning

confidence: 99%

Rosa canina L. – new possibilities for an old medicinal herb

Živković¹,

Stojković

Petrović

et al. 2015

Food Funct.

View full text Add to dashboard Cite

show abstract

“…This hypothesis is in agreement with that previously suggested by many researchers for different plant extracts exerting antidiarrheal activity. [ 20 21 ]…”

Section: Discussionmentioning

confidence: 99%

Antidiarrheal activity of ethanolic extract of Manihot esculenta Crantz leaves in Wistar rats

Bahekar¹,

Kale²

2015

J Ayurveda Integr Med

View full text Add to dashboard Cite

Background:Use of Manihot esculenta Crantz (MEC) plant has been mentioned in literature of Food and Agriculture Organization of United Nations, Central Tuber Crops Research Institute and many others. It is also known commonly as tapioca, continues to be a crop of food security for the millions of people, especially in the developing countries of the globe including India. Medicinal uses of this plant including diarrhea have been mentioned in literature, but scientific evidence is lacking.Objective:The objective was to study antidiarrheal activity of ethanolic leaf extract of MEC in Wistar rats.Materials and Methods:Ethanolic extract of MEC leaves in the doses of 50 mg/kg, 100 mg/kg and 200 mg/kg were used in Wistar rats of either sex. Experimental models used were castor oil-induced intestinal fluid accumulation and charcoal passage test. Loperamide and atropine sulfate were the standard drugs used in these models respectively.Results:MEC extracts decreased intestinal fluid volume in dose dependent manner no extract group was comparable with standard drug loperamide (5 mg/kg). MEC extracts also significantly inhibited gastrointestinal motility in dose dependent manner. MEC (100 mg/kg) and MEC (200 mg/kg) were comparable with standard drug atropine sulfate (5 mg/kg) in this aspect. <0.05 were considered to be significant.Conclusions:Ethanolic extract of MEC leaves exhibited significant antidiarrheal activity by decreasing intestinal fluid accumulation and the gastrointestinal motility in Wistar rats.

show abstract

“…Rosa canina L. possesses therapeutic activities against various inflammatory disorders such as rheumatism, arthritis and gout, in addition to other diseases like cold and influenza [ 19 , 20 ]. Rosa canina L. was used as a treatment for gastrointestinal tract diseases such as gastric ulcers [ 21 ] and diarrhea [ 22 ]. The biological activities of Rosa canina L. are attributed to the high levels of bioactive molecules such as vitamin C, carotenoids, anthocyanins, and phenolic acids [ 16 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Rosa canina L. Can Restore Endoplasmic Reticulum Alterations, Protein Trafficking and Membrane Integrity in a Dextran Sulfate Sodium-Induced Inflammatory Bowel Disease Phenotype

Wanes

Toutounji²,

Sebaï

et al. 2021

Nutrients

View full text Add to dashboard Cite

Rosa canina L. is a natural polyphenol-rich medicinal plant that exhibits antioxidant and anti-inflammatory activities. Recent in vivo studies have demonstrated that a methanol extract of Rosa canina L. (RCME) has reversed an inflammatory bowel disease (IBD)-like phenotype that has been triggered by dextran sulfate sodium (DSS) in mice. In the current study, we investigated the effects of RCME on perturbations of cellular mechanisms induced by DSS-treatment of intestinal Caco-2 cells, including stress response in the endoplasmic reticulum (ER), protein trafficking and sorting as well as lipid rafts integrity and functional capacities of an intestinal enzyme. 6 days post-confluent cells were treated for 24 h with DSS (3%) or simultaneously with DSS (3%) and RCME (100 µg/mL) or exclusively with RCME (100 µg/mL) or not treated. The results obtained demonstrate the ability of RCME to counteract the substantial increase in the expression levels of several ER stress markers in DSS-treated cells. Concomitantly, the delayed trafficking of intestinal membrane glycoproteins sucrase-isomaltase (SI) and dipeptidyl peptidase 4 (DPP4) induced by DSS between the ER and the Golgi has been compromised by RCME. Furthermore, RCME restored the partially impaired polarized sorting of SI and DPP4 to the brush border membrane. An efficient sorting mechanism of SI and DPP4 is tightly associated with intact lipid rafts structures in the trans-Golgi network (TGN), which have been distorted by DSS and normalized by RCME. Finally, the enzymatic activities of SI are enhanced in the presence of RCME. Altogether, DSS treatment has triggered ER stress, impaired trafficking and function of membrane glycoproteins and distorted lipid rafts, all of which can be compromised by RCME. These findings indicate that the antioxidants in RCME act at two major sites in Caco-2 cells, the ER and the TGN and are thus capable of maintaining the membrane integrity by correcting the sorting of membrane-associated proteins.

show abstract

Role of the Rosa canina L. leaf extract as an antidiarrheal drug in rodents

Cited by 11 publications

References 18 publications

Rosa canina L. – new possibilities for an old medicinal herb

Rosa canina L. – new possibilities for an old medicinal herb

Antidiarrheal activity of ethanolic extract of Manihot esculenta Crantz leaves in Wistar rats

Rosa canina L. Can Restore Endoplasmic Reticulum Alterations, Protein Trafficking and Membrane Integrity in a Dextran Sulfate Sodium-Induced Inflammatory Bowel Disease Phenotype

Contact Info

Product

Resources

About