Role of the serotonergic system in appetite and ingestion control

Lee, Michelle D.; Clifton, Peter G.

doi:10.1016/b978-0-444-64125-0.00027-x

Cited by 4 publications

(2 citation statements)

References 169 publications

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“…In studies with rodents, there are mixed effects of SSRI exposure on sex difference in feeding and changes in weight (Currie et al 2004 ; Hutchison et al 2018 ). 5-HT is directly involved in regulation of feeding (Lee and Clifton 2010 ). It should be noted that the previously mentioned studies on rodents were not performed with citalopram as in the current study, but with fluoxetine, another SSRI.…”

Section: Discussionmentioning

confidence: 99%

Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus)

Kellner

Olsén

2020

Arch Environ Contam Toxicol

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Selective serotonin reuptake inhibitors (SSRIs) are psychotropic pharmaceuticals used as antidepressants. SSRIs are commonly found in surface waters in populated areas across the globe. They exert their effect by blocking the serotonin re-uptake transporter in the presynaptic nerve ending. The present study examined whether behavioural effects to exposure to SSRI citalopram depend on personality and sex in the stickleback (Gasterosteus aculeatus). Three aspects of stickleback behaviour are examined: feeding behaviour, aggression, and boldness. We exposed sticklebacks to 350–380 ng/l citalopram for 3 weeks. Feeding and aggressive behaviour were recorded before and after exposure, whereas scototaxis behaviour was tested after exposure. The results show treatment effects in feeding and aggressive behaviour. Feeding is suppressed only in the male group (χ2 = 20.4, P < 0.001) but not in the females (χ2 = 0.91, P = 0.339). Aggressive behaviour was significantly affected by treatment (χ2 = 161.9, P < 0.001), sex (χ2 = 86.3, P < 0.001), and baseline value (χ2 = 58.8, P < 0.001). Aggressiveness was suppressed by citalopram treatment. In addition, the fish showed no change in aggression and feeding behaviour over time regardless of sex and treatment, which indicate personality traits. Only females are affected by treatment in the scototaxis test. The exposed females spent significantly (χ2 = 5.02, P = 0.050) less time in the white zone than the female controls.

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Section: Discussionmentioning

confidence: 99%

Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus)

Kellner

Olsén

2020

Arch Environ Contam Toxicol

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“…Overall, the influence of 5-HT synaptic activity in the brain on various behaviors is incredibly significant . It has been shown that 5-HT plays a vital role in behaviors related to feeding, − anxiety, fear and aggression, , learning and memory, , reinforcement, − performance monitoring, adjustment to errors, and reproductive behavior . Moreover, 5-HT is important in dealing with stress, , and in processes that govern consciousness …”

Section: -Ht Activity and Signal Throughputmentioning

confidence: 99%

Serotonin Signaling through Lipid Membranes

Kalinichenko,

Kornhuber,

Sinning

et al. 2024

ACS Chem. Neurosci.

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Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental disorders. Primarily, membrane proteins controlling the expression and activity of 5-HT synthesis, storage, release, receptor activation, and inactivation are critical to 5-HT signaling in synaptic and extra-synaptic sites. Moreover, these signals represent information transmission across membranes. Although the lipid membrane environment is often viewed as fairly stable, emerging research suggests significant functional lipid−protein interactions with many synaptic 5-HT proteins. These protein−lipid interactions extend to almost all the primary lipid classes that form the plasma membrane. Collectively, these lipid classes and lipid−protein interactions affect 5-HT synaptic efficacy at the synapse. The highly dynamic lipid composition of synaptic membranes suggests that these lipids and their interactions with proteins may contribute to the plasticity of the 5-HT synapse. Therefore, this broader protein−lipid model of the 5-HT synapse necessitates a reconsideration of 5-HT's role in various associated mental disorders.

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Tapping into 5-HT3 Receptors to Modify Metabolic and Immune Responses

Irving

Turek

Kettle

et al. 2021

IJMS

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5-hydroxytryptamine type 3 (5-HT3) receptors are ligand gated ion channels, which clearly distinguish their mode of action from the other G-protein coupled 5-HT or serotonin receptors. 5-HT3 receptors are well established targets for emesis and gastrointestinal mobility and are used as adjunct targets in treating schizophrenia. However, the distribution of these receptors is wider than the nervous system and there is potential that these additional sites can be targeted to modulate inflammatory and/or metabolic conditions. Recent progress in structural biology and pharmacology of 5-HT3 receptors have provided profound insights into mechanisms of their action. These advances, combined with insights into clinical relevance of mutations in genes encoding 5-HT3 subunits and increasing understanding of their implications in patient’s predisposition to diseases and response to the treatment, open new avenues for personalized precision medicine. In this review, we recap on the current status of 5-HT3 receptor-based therapies using a biochemical and physiological perspective. We assess the potential for targeting 5-HT3 receptors in conditions involving metabolic or inflammatory disorders based on recent findings, underscoring the challenges and limitations of this approach.

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Role of the serotonergic system in appetite and ingestion control

Cited by 4 publications

References 169 publications

Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus)

Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus)

Serotonin Signaling through Lipid Membranes

Tapping into 5-HT3 Receptors to Modify Metabolic and Immune Responses

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