Role of the SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism

Kontaridis, Maria I.; Geladari, Eleni; Geladari, Charalampia V.

doi:10.1007/978-1-4614-7855-3_8

Cited by 2 publications

(2 citation statements)

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“…The principal anatomical feature of pathological growth of the heart is referred to as hypertrophic cardiomyopathy (HCM), an abnormal, asymmetric LV thickening of the heart [ 4 ]. Specifi cally, pathological hypertrophy is defi ned as an increase in the overall size of cardiac cells, with increased myocardial fi brosis that is distributed throughout the interstitium and in discrete foci [ 10 ].…”

Section: Hypertrophic Cardiomyopathymentioning

confidence: 99%

“…However, over time, this increased signaling induces pathological remodeling of the heart, causing the heart to become abnormally thickened or hypertrophic [ 12 ]. When the heart can no longer keep up with this excess demand, it decompensates, transitioning to dilation and, ultimately causing end-stage HF [ 12 ], a serious lifethreatening condition and one of the most common causes of death worldwide [ 4 ].…”

Section: Hypertrophic Cardiomyopathymentioning

confidence: 99%

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Pathways to Myocardial Hypertrophy

Kontaridis

Geladari

2014

Introduction to Translational Cardiovascular Research

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Pathological cardiac hypertrophy occurs as a consequence of adaptive responses to pressure or volume overload, mutations in sarcomeric (or other) proteins, or loss of contractile mass from prior infarction. While initially compensatory, over time when the heart can no longer meet with the increased metabolic demands of the mechanical work load imposed on the heart, dilation and heart failure ensue. Several signaling pathways are critically important in mediating myocardial hypertrophy, including the G-protein coupled receptor, the calcineurin/NFAT, MAPK, and the PI3K/ AKT/mTOR signaling pathways. Importantly, these signaling pathways also control molecular processes, such as cell proliferation, differentiation, survival, migration and other functions of the cell. In addition, the heart is comprised of several cell lineages make up the heart, including cardiomyocytes, fi broblasts, endothelial cells, and vascular smooth muscle cells, each integrally involved in modulating the signaling events that promote the

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Section: Hypertrophic Cardiomyopathymentioning

confidence: 99%